FB2024_03 , released June 25, 2024
Allele: Dmel\Gr64aUAS.cDa
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General Information
Symbol
Dmel\Gr64aUAS.cDa
Species
D. melanogaster
Name
Gustatory receptor 64a promoter construct of Dahanukar
FlyBase ID
FBal0256893
Feature type
allele
Associated gene
Dmel\Gr64a
Associated Insertion(s)
Carried in Construct
P{UAS-Gr64a.D}
Also Known As
UAS-Gr64a
Key Links
Transgenic product class
cDNA
(Dahanukar et al., 2007)
wild_type
(Dahanukar et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Dahanukar et al., 2007)
wild_type
(Dahanukar et al., 2007)
Mutagen
in vitro construct
(Dahanukar et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Gr64a.D}
Cytology
Description

UAS regulatory sequences drive expression of a full-length Gr64a cDNA.

(Dahanukar et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Gr64a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Gr64aScer\UAS.cDa in ab1C neurons, under the control of Scer\GAL4Gr21a.9.323 or Scer\GAL4Gr63a.PF, is sufficient to confer a response to sucrose, maltose, maltotriose, fructose and glycerol.

      (Freeman et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Gr64aUAS.cDa/Scer\GAL4Gr5a.8.5 partially rescues Gr64a1/Df(3L)Gr64a2

      (Dahanukar et al., 2007)
      Comments

      The defects in the electrophysiological response to various sugars which is seen in the L-type labellar sensilla of Gr64a1/Df(3L)Gr64a2 flies are rescued by expression of Gr64aScer\UAS.cDa under the control of Scer\GAL4Gr5a.8.5.

      Expression of Gr64aScer\UAS.cDa under the control of Scer\GAL4Gr5a.8.5 increases the mean proboscis extension response to all sugars whose responses are reduced in Gr64a1 flies.

      Expression of Gr64aScer\UAS.cDa under the control of Scer\GAL4Gr5a.8.5 partially rescues the reduced proboscis extension responses to maltotriose and sucrose which are seen in a walking proboscis extension assay in Gr64a1/Df(3L)Gr64a2 flies.

      (Dahanukar et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gr64aScer\UAS.cDa
      Gr64aUAS.cDa
      Name Synonyms
      Gustatory receptor 64a promoter construct of Dahanukar
      Secondary FlyBase IDs
        References (2)