FlyBase Allele Report: Dmel\Krn[NIG.8056R]

General Information

Symbol

Dmel\Krn^NIG.8056R

Species

D. melanogaster

Name

FlyBase ID

FBal0257031

Feature type

allele

Associated gene

Dmel\Krn

Associated Insertion(s)

Carried in Construct

P{NIG.8056R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.8056R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-8056R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates colorectal cancer

modeled by SH3PX1^JF02730

(Zhang et al., 2019)

modeled by SH3PX1^d1

(Zhang et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^how-24B

(Buchon et al., 2010)

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^how-24B

(Buchon et al., 2010)

Phenotype Manifest In

midgut, with Scer\GAL4^how-24B, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

Detailed Description

Statement

Reference

Expression of Krn^NIG.8056R in precursor cells under the control of Scer\GAL4^how-24B and Scer\GAL80^ts.αTub84B results in reduced epithelial renewal and intestinal stem cell (ISC) proliferation after Erwinia carotovora carotovora 15 (Ecc15) infection compared with wild-type.

(Buchon et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Krn^NIG.8056R, Scer\GAL4^esg.PU is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of SH3PX1^JF02730, Scer\GAL4^esg.PU

(Zhang et al., 2019)

NOT Suppressor of

Statement

Reference

Krn^NIG.8056R/Scer\GAL4^NP0001 is a non-suppressor of increased occurrence of cell division | recessive | adult stage phenotype of SH3PX1^d1

(Zhang et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Krn^NIG.8056R, Scer\GAL4^esg.PU is a suppressor | partially of adult midgut epithelium phenotype of SH3PX1^JF02730, Scer\GAL4^esg.PU

(Zhang et al., 2019)

NOT Suppressor of

Statement

Reference

Krn^NIG.8056R/Scer\GAL4^NP0001 is a non-suppressor of adult midgut epithelium phenotype of SH3PX1^d1

(Zhang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Krn^NIG.8056R

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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