FlyBase Gene Report: Dmel\Krn

General Information

Symbol

Dmel\Krn

Species

D. melanogaster

Name

Keren

Annotation Symbol

CG32179

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052179

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

gritz

Key Links

Genomic Location

Cytogenetic map

74E4-74E4

Sequence location

3L:17,649,562..17,654,280 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:17649562..17654280

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables receptor ligand activity

inferred from direct assay

(Reich and Shilo, 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables epidermal growth factor receptor binding

inferred from electronic annotation with InterPro:IPR043403

(InterPro Project Members, 2004-)

enables receptor ligand activity

inferred from electronic annotation with InterPro:IPR043403

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000960795

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in compound eye development

inferred from genetic interaction with FLYBASE:S; FB:FBgn0003310

(Brown et al., 2007)

inferred from mutant phenotype

(Brown and Freeman, 2003)

involved_in epidermal growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:S; FB:FBgn0003310

(Brown et al., 2007)

inferred from genetic interaction with FLYBASE:spi; FB:FBgn0005672

(Brown et al., 2007)

inferred from mutant phenotype

(Reich and Shilo, 2002, Urban et al., 2002)

involved_in olfactory learning

inferred from mutant phenotype

(Rahn et al., 2013)

involved_in positive regulation of border follicle cell migration

inferred from mutant phenotype

(McDonald et al., 2006)

involved_in positive regulation of cell population proliferation

inferred from mutant phenotype

(Buchon et al., 2010, Jiang and Edgar, 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell surface receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000960795

(GO Reference Genome Project, 2011-)

involved_in epidermal growth factor receptor signaling pathway

inferred from electronic annotation with InterPro:IPR043403

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Schlesinger et al., 2004)

located_in extracellular space

inferred from direct assay

(Reich and Shilo, 2002)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

EGFR AGONISTS

Pathway (FlyBase)

EGFR Signaling Pathway Core Components

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

EGFR Signaling Pathway Core Components -: The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).

Gene Group (FlyBase)

EGFR AGONISTS -: Epidermal Growth Factor Receptor (EGFR) agonists are secreted ligands that activate the Egfr receptor tyrosine kinase.

Summary (Interactive Fly)

ligand for Epidermal growth factor receptor - homolog of Spitz with partially independent functional activity - provides an autocrine mitogenic stimulus in midgut progenitor cells

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Krn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VVJ6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Shares 5' UTR with downstream gene.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Krn-RA

FBtr0075197

NM_079405

1354

217

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Krn-PA

FBpp0074961

24.1

217

8.16

Q9VVJ6

NP_524129

AAF49315

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VVJ6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Krn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Krn_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.04

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

wandering third instar larval stage

midgut imaginal island

(Jiang and Edgar, 2009)

adult stage

intestinal stem cell

(Xu et al., 2011)

Additional Descriptive Data

Krn is expressed in small diploid cells located basally in the epithelium, which are likely intestinal stem cells.

(Xu et al., 2011)

Krn transcript is expressed in the adult midgut precursor cells.

(Jiang and Edgar, 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Schlesinger et al., 2004)

located_in extracellular space

inferred from direct assay

(Reich and Shilo, 2002)

Expression Deduced from Reporters

Reporter: P{Krn-GAL4.R}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

adult mushroom body

(Rahn et al., 2013)

embryonic/larval mushroom body

(Rahn et al., 2013)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Krn in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Krn

View exonic expression by tissue for Dmel\Krn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052179

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

326198/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052179

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052179

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052179

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32179

Flygut - An atlas of the Drosophila adult midgut

FBgn0052179

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Krn

Transgenic constructs containing regulatory region of Krn

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(3L)81k19

(Schupbach, 2000.3.3)

Df(3L)Exel9005

(Ryder, 2004.4.26)

Df(3L)Krn-27-7-B

(McDonald et al., 2006)

Gene partially disrupted in

Df(3L)Krn^9-6-A

(McDonald et al., 2006)

Df(3L)Krn²⁵

(Brown et al., 2007)

Df(3L)Krn²⁴²

(Brown et al., 2007)

Df(3L)Krn²⁶⁰

(Brown et al., 2007)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^69B

lethal, with Scer\GAL4^cb41

Krn^s.UAS.cUa

partially lethal - majority die, with Scer\GAL4^Bx-MS1096

Krn^s.UAS.cRa

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Krn^GD130

viable

Krn^9-6-A

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

Krn^9-6-A

Other Phenotypes

Allele

abnormal cell polarity, with Scer\GAL4^hs.PB

Krn^UAS.cUa

abnormal cell polarity, with Scer\GAL4^sev.EP

Krn^UAS.cUa

abnormal immune response | adult stage, with Scer\GAL4^how-24B

Krn^NIG.8056R

abnormal learning | third instar larval stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Krn^KK107190

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^how-24B

Krn^NIG.8056R

increased cell number, with Scer\GAL4^NP7397

Krn^UAS.cRa

increased cell number | third instar larval stage, with Scer\GAL4^NP7397

Krn^s.UAS.cRa

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

Krn^s.UAS.cRa

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

Krn^s.UAS.cUa

increased occurrence of cell division | adult stage, with Scer\GAL4^NP7397

Krn^s.UAS.cRa

some die during pupal stage, with Scer\GAL4^pnr-MD237

Krn^GD130

Phenotype manifest in

Allele

adult midgut progenitor cell, with Scer\GAL4^NP7397

Krn^UAS.cRa

adult midgut progenitor cell | third instar larval stage, with Scer\GAL4^NP7397

Krn^s.UAS.cRa

border follicle cell, with Scer\GAL4^slbo.2.6

Krn^s.UAS.cUa

border follicle cell | somatic clone, with Scer\GAL4^cb41

Krn^s.UAS.cUa

cephalopharyngeal skeleton, with Scer\GAL4^69B

cone cell | increased number, with Scer\GAL4^sev.EP

Krn^UAS.cUa

denticle | ectopic, with Scer\GAL4^arm.PS

Krn^s.UAS.cUa

dorsal appendage | ectopic, with Scer\GAL4^55B

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Pxn.PS

Krn^EY11963

enterocyte, with Scer\GAL4^NP7397

Krn^s.UAS.cRa

eye, with Scer\GAL4^GMR.PF

intestinal stem cell, with Scer\GAL4^NP7397, Scer\GAL80^ts.αTub84B

Krn^s.UAS.cRa

midgut, with Scer\GAL4^how-24B, Scer\GAL80^ts.αTub84B

Krn^NIG.8056R

midgut, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

Krn^s.UAS.cUa

midgut, with Scer\GAL4^unspecified

Krn^s.UAS.cUa

midgut interstitial cell, with Scer\GAL4^NP7397

Krn^s.UAS.cRa

ommatidium, with Scer\GAL4^GMR.PF

Krn^UAS.cRa

ommatidium, with Scer\GAL4^hs.PB

Krn^UAS.cUa

ommatidium, with Scer\GAL4^sev.EP

Krn^UAS.cUa

ventral denticle belt, with Scer\GAL4^69B

Krn^s.UAS.cRa

wing, with Scer\GAL4^Bx-MS1096

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

Krn^s.UAS.cUa

wing vein | ectopic, with Scer\GAL4^GMR.PF

Krn^UAS.cUa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

Hsap\NRG1

2 of 14

Yes

Hsap\NRG2

2 of 14

Yes

Hsap\AREG

1 of 14

Yes

Hsap\BTC

1 of 14

Yes

Hsap\EGF

1 of 14

Hsap\EPGN

1 of 14

Yes

Hsap\EREG

1 of 14

Yes

Hsap\HBEGF

1 of 14

Yes

Hsap\MSANTD3-TMEFF1

1 of 14

Yes

Hsap\NRG3

1 of 14

Hsap\NRG4

1 of 14

Yes

Hsap\TGFA

1 of 14

Yes

Hsap\TMEFF1

1 of 14

Hsap\TMEFF2

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Nrg1

2 of 14

Yes

Rnor\Nrg2

2 of 14

Yes

Rnor\Areg

1 of 14

Yes

Rnor\Btc

1 of 14

Yes

Rnor\Egf

1 of 14

Rnor\Epgn

1 of 14

Yes

Rnor\Ereg

1 of 14

Yes

Rnor\Hbegf

1 of 14

Yes

Rnor\Nrg4

1 of 14

Yes

Rnor\Tgfa

1 of 14

Yes

Rnor\Tmeff1

1 of 14

Rnor\Tmeff2

1 of 14

Yes

Mus musculus (laboratory mouse) (13)

Mmus\Nrg1

2 of 14

Yes

Mmus\Areg

1 of 14

Yes

Mmus\Btc

1 of 14

Yes

Mmus\Egf

1 of 14

Mmus\Epgn

1 of 14

Yes

Mmus\Ereg

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tgfa

1 of 14

Yes

Mmus\Tmeff1

1 of 14

Mmus\Tmeff2

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\areg

1 of 13

Yes

Xtro\btc

1 of 13

Yes

Xtro\egf

1 of 13

Yes

Xtro\fat1

1 of 13

Yes

Xtro\nrg3

1 of 13

Yes

Xtro\tmeff1

1 of 13

Yes

Danio rerio (Zebrafish) (17)

Drer\areg

1 of 14

Yes

Drer\btc

1 of 14

Yes

Drer\dlc

1 of 14

Yes

Drer\egf

1 of 14

Yes

Drer\epgn

1 of 14

Yes

Drer\hbegfa

1 of 14

Yes

Drer\hbegfb

1 of 14

Yes

Drer\lrp1bb

1 of 14

Yes

Drer\nrg1

1 of 14

Yes

Drer\nrg2a

1 of 14

Yes

Drer\nrg2b

1 of 14

Yes

Drer\nrg3b

1 of 14

Yes

Drer\tgfa

1 of 14

Yes

Drer\tmeff1b

1 of 14

Yes

Drer\tmeff2a

1 of 14

Yes

Drer\tmeff2b

1 of 14

Yes

Drer\zanl

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\lin-3

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP012986

5 of 12

Yes

Agam\AgaP_AGAP010312

4 of 12

Yes

Agam\AgaP_AGAP012663

4 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Krn. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

spi

9 of 13

grk

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Krn^NIG.8056R

ameliorates colorectal cancer

modeled by SH3PX1^JF02730

(Zhang et al., 2019)

modeled by SH3PX1^d1

(Zhang et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Krn - mir-bft

quantitative reverse transcription pcr

(Kim et al., 2017)

protein-protein

Physical Interaction

Assay

References

Krn - rho

inferred by author, enzymatic study, anti tag western blot

(Urban et al., 2002, Urban et al., 2002)

Krn - rho-4

inferred by author, enzymatic study, anti tag western blot

(Urban et al., 2002)

Krn - ru

inferred by author, enzymatic study, anti tag western blot

(Urban et al., 2002)

Krn - stet

inferred by author, enzymatic study, anti tag western blot

(Urban et al., 2002)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Krn

suppressible

Egfr

(Reich and Shilo, 2002)

Krn

suppressible

Ras85D

(Reich and Shilo, 2002)

Krn

suppressible

Sos

(Reich and Shilo, 2002)

spi|Krn

enhanceable

(Austin et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

AdamTS-B

suppressible

vn|spi|Krn

(Butchar et al., 2012)

AdamTS-B

suppressible

vn|Krn

(Butchar et al., 2012)

AdamTS-B

suppressible

spi|Krn

(Butchar et al., 2012)

enhanceable

Krn

(Brown et al., 2007)

SH3PX1

suppressible

Krn

(Zhang et al., 2019)

spi

enhanceable

Krn

(Austin et al., 2014)

spi|vn

enhanceable

Krn

(Austin et al., 2014)

suppressible

(Liu et al., 2010)

suppressible

(Jiang et al., 2011)

enhanceable

Krn

(Austin et al., 2014)

suppressible

Krn

(Austin et al., 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

77452

DroID - A comprehensive database of gene and protein interactions.

FBgn0052179

MIST (genetic) - An integrated Molecular Interaction Database

326198

MIST (protein-protein) - An integrated Molecular Interaction Database

326198

Pathways

Signaling Pathways (FlyBase)

EGFR Signaling Pathway Core Components -: The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VVJ6

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

74E4-74E4

Sequence location

3L:17,649,562..17,654,280 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

74E4-74E4

Limits computationally determined from genome sequence between P{lacW}l(3)j11B2^j11B2 and P{PZ}W⁰⁵⁰¹⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

74D-74D

(Reich, 2000.3.14)

74E-74F

(determined by in situ hybridisation)

(Schupbach, 2000.3.3)

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-41.1

(Comeron et al., 2012)

(Kadlec et al., 2000)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD34429

Other clones

DPiM_LD34429

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052179

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052179

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Krn as part of thr Egfr pathway has a role in ommatidial rotation.

(Brown and Freeman, 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Keren gritz

(FlyBase, 1996-)

Additional comments

Source for identity of Keren CG8056 was sequence comparison ( date:000414 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Keren CG8056

(FlyBase, 1996-)

Nomenclature comments

Etymology

Called "gritz" because it is related to both "gurken" and "spitz".

(Kadlec et al., 2000)

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG32179

(National Institute of Genetics Fly Stocks, 2023-, Keleman et al., 2009.8.5, McDonald et al., 2006)

CG8056

CT19073

(Hynes and Zhao, 2000)

KRN

(Ferrandon, 2013)

Ker

(Urban et al., 2002)

Keren

(Jasper, 2020, Buchon et al., 2013)

gritz

(Kadlec et al., 2000, Schupbach, 2000.3.3)

keren

(Wang et al., 2016, Shilo, 2003, Kadlec et al., 2001)

keren/spitz2

(Li and White, 2003)

krn

(Petsakou et al., 2023, Strilbytska et al., 2020, Xu et al., 2017, Zhang et al., 2017, Tian et al., 2016, Wang et al., 2016, Kux and Pitsouli, 2014, Li et al., 2014, Butchar et al., 2012, Liu et al., 2010, Brown et al., 2007)

s-krn

(Montell, 2006)

skrn

(Wang et al., 2010)

Name Synonyms

Spitz2

(Buchon et al., 2009)

keren

(Ahmed et al., 2020, Tan et al., 2017, Rahn et al., 2013, Liu et al., 2010, Zhang et al., 2009, Brown et al., 2007)

spitz-2

(Baonza et al., 2001)

spitz2

(Frankfort and Mardon, 2002)

Secondary FlyBase IDs

FBgn0036744
FBgn0041151
FBgn0064124

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

326198

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VVJ6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VVJ6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VVJ6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052179

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

326198/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052179

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052179

FlyMine - An integrated database for Drosophila genomics

FBgn0052179

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32179

MARRVEL_MODEL - MARRVEL (model organism gene)

326198

Linkouts

BioGRID - A database of protein and genetic interactions.

77452

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052179

DroID - A comprehensive database of gene and protein interactions.

FBgn0052179

DRSC - Results frm RNAi screens

FBgn0052179

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Krn_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052179

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052179

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32179

Flygut - An atlas of the Drosophila adult midgut

FBgn0052179

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003429

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

326198

MIST (protein-protein) - An integrated Molecular Interaction Database

326198

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VVJ6

References (130)

The following external sites may use different assemblies or annotations than FlyBase.

-0.04

Report Sections