FB2024_03 , released June 25, 2024
Allele: Dmel\pntRNAi.UAS.cUa
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General Information
Symbol
Dmel\pntRNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0257033
Feature type
allele
Associated gene
Dmel\pnt
Associated Insertion(s)
Carried in Construct
P{UAS-pnt.RNAi.U}
Key Links
Transgenic product class
RNAi_reagent
(Buchon et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Buchon et al., 2010)
Mutagen
in vitro construct
(Buchon et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-pnt.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of a pnt RNAi construct.

(Buchon et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
pnt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  colorectal cancer
      modeled by SH3PX1HMJ21552
      (Zhang et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of pntdsRNA.Scer\UAS.cUa RNAi under the control of Scer\GAL4esg-NP5130 (using tub-Gal80[ts] to limit the time of RNAi expression) results in a suppression of regeneration-associated proliferation of intestinal stem cells in the adult midgut upon Pseudomonas entomophila-induced enteric infection.

      (Jin et al., 2015)

      In contrast to wild-type flies, Erwinia carotovora carotovora 15 (Ecc15) infection does not increase the number of mitotic cells in flies expressing pntdsRNA.Scer\UAS.cUa in intestinal stem cells (ISCs) under the control of Scer\GAL4esg-NP5130 and Scer\GAL80ts.αTub84B.

      (Buchon et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The overproliferation of intestinal stem cells and the increase in the mitotic rate in the adult midgut observed in flies expressing cicKK100838 under the control of either Scer\GAL4esg-NP5130 or Scer\GAL4Dl.PU (using tub-Gal80[ts] to limit the time of RNAi expression) is strongly suppressed by co-expression of pntdsRNA.Scer\UAS.cUa.

      (Jin et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      pntRNAi.UAS.cUa
      pntdsRNA.Scer\UAS.cUa
      pntdsRNA.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (5)