FlyBase Allele Report: Dmel\Pi4KIIIα[GL00144]

General Information

Symbol

Dmel\Pi4KIIIα^GL00144

Species

D. melanogaster

Name

FlyBase ID

FBal0262623

Feature type

allele

Associated gene

Dmel\Pi4KIIIα

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00144}

Also Known As

UAS-PI4KIIIα-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00144}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00144

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav-C155

(Choudhury et al., 2016)

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

NMJ bouton | larval stage, with Scer\GAL4^elav-C155

(Choudhury et al., 2016)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in a rough eye phenotype.

(Pletcher et al., 2019)

Expression of PI4KIIIα^GL00144 under the control of Scer\GAL4^ey.PU results in a normal eye. Expression under the control of Scer\GAL4^Toll-6-D42 results in sluggish 3rd instar larvae which die.

Expression under the control of Scer\GAL4^elav-C155 results in sluggish 3rd instar larvae which die. This expression under the control of Scer\GAL4^elav-C155 also leads to a significant increase in the number of boutons at the larval muscle 6/7 NMJs, as compared to controls.

(Choudhury et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Pi4KIIIα^GL00144/Scer\GAL4^αTub84B.PL is a non-enhancer of increased cell number | P-stage | somatic clone - tissue specific phenotype of mtm^null

(Hu et al., 2022)

NOT Suppressor of