FlyBase Allele Report: Dmel\TER94[GL00448]

General Information

Symbol

Dmel\TER94^GL00448

Species

D. melanogaster

Name

FlyBase ID

FBal0262914

Feature type

allele

Associated gene

Dmel\TER94

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00448}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00448}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00448

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of primary ovarian insufficiency

CEA

(Gorsi et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^fl.SCA3.UAS

(Ristic et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage, with Scer\GAL4^{Delta-05151-G}

(Liu et al., 2022)

increased cell number | adult stage, with Scer\GAL4^NP5130

(Liu et al., 2022)

increased cell number | adult stage, with Scer\GAL4^{Su(H).GBE.cLa}

(Liu et al., 2022)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Liu et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adulthood expression of TER94^GL00448 under the control of Scer\GAL4^NP5130 for 7 days leads to an increase in the number and proportion of progenitors (i.e. esg-positive) and stem cells (i.e. Dl-positive) in the midgut, as well as increase in the mitotic index; there are also increased proportion of enteroblasts in the midgut. Many large esg-positive also express the EC marker Pdm1, indicative of intestinal homeostasis loss.

Adulthood expression of TER94^GL00448 under the control of Scer\GAL4^Dl-05151-G for 7 days leads to an increase in the number of stem cells and enteroblasts in the midgut.

Adulthood expression of TER94^GL00448 under the control of Scer\GAL4^{Su(H).GBE.cLa} for 7 days leads to an increase in the number of enteroblasts in the midgut.

(Liu et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^NP5130, TER94^GL00448 has increased cell number | adult stage phenotype, suppressible by Cat^UAS.cAa, Scer\GAL4^NP5130

(Liu et al., 2022)

Scer\GAL4^NP5130, TER94^GL00448 has increased cell number | adult stage phenotype, suppressible by Scer\GAL4^NP5130/cnc^UAS.cSa