FlyBase Allele Report: Dmel\HDAC3[HMS00087]

General Information

Symbol

Dmel\HDAC3^HMS00087

Species

D. melanogaster

Name

FlyBase ID

FBal0263092

Feature type

allele

Associated gene

Dmel\HDAC3

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00087}

Also Known As

hdac3 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00087}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00087

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cardiomyopathy

CEA

(Ren et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cardiomyopathy

is ameliorated by HDAC3^WT.RR

(Ren et al., 2023)

is ameliorated by HDAC3^K26A.RR

(Ren et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

increased cell number | larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

(Rives-Quinto et al., 2020)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

lethal, with Scer\GAL4^en.PU

(Dietz et al., 2015)

lethal, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

embryonic/larval brain | larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

(Rives-Quinto et al., 2020)

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

type II neuroblast | increased number | larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

(Rives-Quinto et al., 2020)

wing, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of HDAC3^HMS00087 under the control of Scer\GAL4^wor.PA (in combination with Scer\GAL80^ase.PN to restrict the expression to type II neuroblasts and Dicer-2 transgene to enhance RNAi efficiency) leads to an increase in the number of type II neuroblasts in larval brains.

(Rives-Quinto et al., 2020)

Expression of HDAC3^HMS00087 under the control of either Scer\GAL4^Act5C.PI or Scer\GAL4^en.PU is pupal lethal at both 25 and 18[o]C, expression controlled by Scer\GAL4^ey.PH is pharate pupal lethal at 25[o]C and leads to small rough eye phenotype at 18[o]C and when driven by Scer\GAL4^nub.PK leads to unfurled wings (at at both 25 and 18[o]C), no overt adult phenotype is observed with the Scer\GAL4^GMR.PF driver.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

HDAC3^HMS00087, Scer\GAL4^wor.PA, Scer\GAL80^ase.PN has increased cell number | larval stage phenotype, enhanceable by ham²/ham[+]

(Rives-Quinto et al., 2020)

HDAC3^HMS00087, Scer\GAL4^wor.PA, Scer\GAL80^ase.PN has increased cell number | larval stage phenotype, enhanceable by erm[+]/erm¹