FlyBase Allele Report: Dmel\Caf1-105[NIG.12892R]

General Information

Symbol

Dmel\Caf1-105^NIG.12892R

Species

D. melanogaster

Name

FlyBase ID

FBal0271383

Feature type

allele

Associated gene

Dmel\Caf1-105

Associated Insertion(s)

Carried in Construct

P{NIG.12892R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.12892R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-12892R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^en-e16E

(Yu et al., 2013)

visible, with Scer\GAL4^ey.PH

(Yu et al., 2013)

visible, with Scer\GAL4^sd.PU

(Yu et al., 2013)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Yu et al., 2013)

wing, with Scer\GAL4^en-e16E

(Yu et al., 2013)

wing, with Scer\GAL4^sd.PU

(Yu et al., 2013)

Detailed Description

Statement

Reference

Flies expressing Caf1-105^NIG.12892R under the control of Scer\GAL4^ey.PH exhibit a mild small-eye phenotype.

Expression of Caf1-105^NIG.12892R in the wing under the control of Scer\GAL4^sd.PU leads to a notched wing phenotype. These wings typically exhibit notches are the wing margin of the anterior/posterior (A/P) boundary and mildly thickened veins at longitudinal vein 3 and 5. A notched wing phenotype is also seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^en-e16E.

(Yu et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, enhanceable by Delta^RevF10/Dl[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, enhanceable by mam²/mam[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, enhanceable by eyg^M3-12/eyg[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^sd.PU has visible phenotype, enhanceable by N¹/N[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, enhanceable by N¹/N[+]

(Yu et al., 2013)

NOT Enhanced by

Statement

Reference

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, non-enhanceable by smo[+]/smo³

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, non-enhanceable by yki[+]/yki^MB09079

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, non-enhanceable by tkv⁷/tkv[+]

(Yu et al., 2013)

Suppressed by

Statement

Reference

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has visible phenotype, suppressible by H[+]/H¹

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^sd.PU has visible phenotype, suppressible by H[+]/H¹

(Yu et al., 2013)

Enhancer of

Statement

Reference

Scer\GAL4^sd.PU/Caf1-105^NIG.12892R is an enhancer of visible phenotype of N¹

(Yu et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, enhanceable by Delta^RevF10/Dl[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, enhanceable by mam²/mam[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, enhanceable by eyg^M3-12/eyg[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^sd.PU has wing phenotype, enhanceable by N¹/N[+]

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, enhanceable by N¹/N[+]

(Yu et al., 2013)

NOT Enhanced by

Statement

Reference

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, non-enhanceable by smo[+]/smo³

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, non-enhanceable by yki[+]/yki^MB09079

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, non-enhanceable by tkv⁷/tkv[+]

(Yu et al., 2013)

Suppressed by

Statement

Reference

Caf1-105^NIG.12892R, Scer\GAL4^ey.PH has eye phenotype, suppressible by H[+]/H¹

(Yu et al., 2013)

Caf1-105^NIG.12892R, Scer\GAL4^sd.PU has wing phenotype, suppressible by H[+]/H¹

(Yu et al., 2013)

Enhancer of

Statement

Reference

Scer\GAL4^sd.PU/Caf1-105^NIG.12892R is an enhancer of wing phenotype of N¹

(Yu et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of smo³ does not enhance the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of yki^MB09079 does not enhance the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of Egfr^f2 does not enhance the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of tkv⁷ does not enhance the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of N¹ enhances the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of H¹ fully suppresses the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of Dl^RevF10 enhances the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of mam² enhances the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of eyg^M3-12 enhances the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of N¹ enhances the wing phenotypes seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^sd.PU. The entire wing margin fails to develop in these flies. Longitudinal veins 3 and 5 are much more thickened than those of N¹/+ flies.

One copy of H¹ suppresses the wing phenotypes seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^sd.PU. Instead the flies have interruption to longitudinal vein 5 in the distal part.

(Yu et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Caf1-105^NIG.12892R is rescued by Caf1-105^UAS.Tag:HA/Scer\GAL4^ey.PH

(Yu et al., 2013)

Comments

Expression of Caf1-105^{Scer\UAS.T:Ivir\HA1} rescues the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

(Yu et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Caf1-105^NIG.12892R

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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