FlyBase Allele Report: Dmel\N[1]

General Information

Symbol

Dmel\N¹

Species

D. melanogaster

Name

FlyBase ID

FBal0029933

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

Also Known As

notch¹

Key Links

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Dietrich and Campos-Ortega, 1984)

loss of function allele

(Lehmann et al., 1983)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult uniglomerular antennal lobe projection neuron lPN | somatic clone | increased number

(Lin et al., 2012)

embryonic epidermis

(Lehmann et al., 1983)

wing (with N^opa23)

(Rice et al., 2015)

wing | female

(Barry et al., 2011)

wing margin

(Xie et al., 2014, Sachan et al., 2013, Xie et al., 2012)

wing vein L5

(Tong et al., 2011)

Detailed Description

Statement

Reference

N¹/+ flies display wing margin defects in the distal region.

(Xie et al., 2014)

N¹ heterozygous adult females frequently display nicks in the wing margin.

(Sachan et al., 2013)

N¹ homozygous lateral antennal lobe neuroblast clones, induced at the newly-hatched larval stage, produce double the number of uniglomerular lateral antennal lobe projection neurons at 24-48 hours after larval hatching and 4 times the number at 48-72 hours after larval hatching, with no acceleration of cell proliferation (EdU incorporation) compared to control clones.

(Lin et al., 2012)

N¹/+ wings have small notches at the wing margin.

(Xie et al., 2012)

Mutant males (derived from heterozygous females) do not survive to adulthood. Heterozygous females are viable but have notched wings.

(Barry et al., 2011)

N¹/+ adult females show wing defects that include thickening of the longitudinal vein 5.

(Tong et al., 2011)

Homozygous clones induced in the eye and thoracic imaginal discs show epidermal development indistinguishable from wild-type.

(Dietrich and Campos-Ortega, 1984)

Intermediate embryonic neurogenic phenotype.

(Lehmann et al., 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N¹ has visible | dominant phenotype, enhanceable by Taf9¹⁹⁰/e(y)1[+]

(Xie et al., 2014)

N¹ has visible | adult stage phenotype, enhanceable by Kap-α3^D93

(Sachan et al., 2013)

N¹ has visible | adult stage phenotype, enhanceable by Kap-α3^D165

(Sachan et al., 2013)

N¹ has visible | adult stage phenotype, enhanceable by Kap-α3^S033513

(Sachan et al., 2013)

N¹ has visible phenotype, enhanceable by Scer\GAL4^sd.PU/Caf1-105^NIG.12892R

(Yu et al., 2013)

N¹ has visible phenotype, enhanceable by Caf1-105[+]/Caf1-105³⁶

(Yu et al., 2013)

N¹ has visible | adult stage phenotype, enhanceable by Scer\GAL4^hh.PU/Hsap\ATXN1L^UAS.Tag:FLAG

(Tong et al., 2011)

Suppressed by

Statement

Reference

N¹ has visible | dominant phenotype, suppressible by Traf6[+]/Traf6^ex1

(Mishra et al., 2014)

N¹ has lethal | male phenotype, suppressible | partially by dgrn[+]/dgrn^EY09862

(Barry et al., 2011)

NOT suppressed by

Statement

Reference

N¹ has visible | dominant | female phenotype, non-suppressible by dgrn[+]/dgrn^DK

(Barry et al., 2011)

Enhancer of

Statement

Reference

N¹/N[+] is an enhancer of visible phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

N¹/N[+] is an enhancer of visible phenotype of Caf1-105^NIG.12892R, Scer\GAL4^sd.PU

(Yu et al., 2013)

N¹/N[+] is an enhancer of visible phenotype of Scer\GAL4^A9, uif^asterisk.UAS

(Xie et al., 2012)

N¹/N[+] is an enhancer of visible | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

Other

Statement

Reference

Hsap\ATXN1L^UAS.Tag:FLAG, N¹, Scer\GAL4^hh.PU has partially lethal - majority die phenotype

(Tong et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

N¹ has wing margin phenotype, enhanceable by Taf9¹⁹⁰/Taf9[+]

(Xie et al., 2014)

N¹ has wing margin phenotype, enhanceable by Kap-α3^D93

(Sachan et al., 2013)

N¹ has wing margin phenotype, enhanceable by Kap-α3^D165

(Sachan et al., 2013)

N¹ has wing margin phenotype, enhanceable by Kap-α3^S033513

(Sachan et al., 2013)

N¹ has wing phenotype, enhanceable by Scer\GAL4^sd.PU/Caf1-105^NIG.12892R

(Yu et al., 2013)

N¹ has wing phenotype, enhanceable by Caf1-105[+]/Caf1-105³⁶

(Yu et al., 2013)

N¹ has wing blade phenotype, enhanceable by Scer\GAL4^hh.PU/Hsap\ATXN1L^UAS.Tag:FLAG

(Tong et al., 2011)

N¹ has wing vein L5 phenotype, enhanceable by Scer\GAL4^hh.PU/Hsap\ATXN1L^UAS.Tag:FLAG

(Tong et al., 2011)

Suppressed by

Statement

Reference

N¹ has wing phenotype, suppressible by Traf6[+]/Traf6^ex1

(Mishra et al., 2014)

NOT suppressed by

Statement

Reference

N¹ has wing | female phenotype, non-suppressible by dgrn[+]/dgrn^DK

(Barry et al., 2011)

Enhancer of

Statement

Reference

N¹/N[+] is an enhancer of eye phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

N¹/N[+] is an enhancer of wing phenotype of Caf1-105^NIG.12892R, Scer\GAL4^sd.PU

(Yu et al., 2013)

N¹/N[+] is an enhancer of wing vein phenotype of Scer\GAL4^A9, uif^asterisk.UAS

(Xie et al., 2012)

N¹/N[+] is an enhancer of notal microchaeta | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

N¹/N[+] is an enhancer of tormogen cell | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

N¹/N[+] is an enhancer of trichogen cell | adult stage | ectopic phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Traf6^ex1 rescues the wing notching phenotype seen in N¹ mutant heterozygotes.

(Mishra et al., 2014)

The wing margin notching phenotype observed in some N¹ heterozygous females is exacerbated by combination with single copy of any of the following alleles: Kap-α3^D93, Kap-α3^D165 or Kap-α3^S033513.

(Sachan et al., 2013)

One copy of N¹ enhances the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of N¹ enhances the wing phenotypes seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^sd.PU. The entire wing margin fails to develop in these flies. Longitudinal veins 3 and 5 are much more thickened than those of N¹/+ flies.

One copy of Caf1-105³⁶ enhances the penetrance of the notched wing phenotype seen in N¹ mutant flies.

(Yu et al., 2013)

The wing vein phenotype resulting from the expression of uif^{asterisk.Scer\UAS} under the control of Scer\GAL4^A9 is enhanced by N¹/+.

(Xie et al., 2012)

The male lethality caused by N¹ is partially rescued by dgrn^EY09862/+.

dgrn^DK/+ does not suppress the wing notching phenotype of N¹/+ females.

(Barry et al., 2011)

Xenogenetic Interactions

Statement

Reference

N¹/+ females ectopically expressing Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^hh.PU rarely survive to adult stage (less than 10%) and the survivors display severe wing defects including a further thickening of the vein L5 compared to N¹/+ controls.

(Tong et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6873

y¹ w^* N¹/FM7c, P{GAL4-twi.G}108.4, P{UAS-2xEGFP}AX

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

N¹

(Kuang et al., 2020, Stroebele and Erives, 2016, Rice et al., 2015, Mishra et al., 2014, Xie et al., 2014, Sachan et al., 2013, Yu et al., 2013, Xie et al., 2012, Barry et al., 2011, Endo et al., 2011, Tong et al., 2011, Ozdowski et al., 2009)

Notch¹

(He et al., 2023)

notch¹

(Lin et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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