FB2024_03 , released June 25, 2024
Allele: Dmel\pdm3UAS.long
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General Information
Symbol
Dmel\pdm3UAS.long
Species
D. melanogaster
Name
FlyBase ID
FBal0277659
Feature type
allele
Associated gene
Dmel\pdm3
Associated Insertion(s)
Carried in Construct
P{UAS-pdm3.long}
Also Known As
UAS-pdm3
Key Links
Transgenic product class
wild_type
(Tichy et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tichy et al., 2008)
Mutagen
in vitro construct
(Tichy et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-pdm3.long}
Cytology
Description

UASt regulatory sequences drive expression of the long pdm3 splice form.

(Tichy et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
pdm3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing pdm3UAS.long under the control of Scer\GAL4GMR22C07 in combination with Scer\GAL80[tsh-GAL80] (to inhibit expression in thoracic segments) induces axon misrouting in vtd2 neurons of abdominal segments 4-6 in third instar larvae. Unlike wild-type controls which innervate the ventral nerve cord, misexpressing vtd2 neurons project into the subesophageal ganglion (SEG), establishing presynaptic brp-positive sites along the way. Their significantly elongated axon is similar in length to wild-type pdm3-positive SEG-targeting vtd1 neurons of abdominal segments 4-6.

      Expressing pdm3UAS.long under the control of Scer\GAL4ppk.PG induces axon targeting defects in class IV da neurons: defasciculation, axon wandering away from the ventral neuropil, and thinning of the axon scaffold near the midline. Some stray class IV da axons project anteriorly towards the SEG.

      (Qian et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      pdm3UAS.long/Scer\GAL4acj6-PG63 partially rescues pdm3f00828

      (Tichy et al., 2008)
      Comments

      Expression of pdm3Scer\UAS.long under the control of Scer\GAL4acj6-PG63 partially rescues the loss of odor response seen in pdm3f00828 mutant pb1A neurons. 7/29 pb1 sensilla show a response when tested with 3 odorants.

      (Tichy et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pdm3Scer\UAS.long
      pdm3UAS.long
      Name Synonyms
      Secondary FlyBase IDs
        References (3)