T6686074C
L464P | Pink1-PH; L464P | Pink1-PE; L464P | Pink1-PG; L464P | Pink1-PD; L464P | Pink1-PC; L464P | Pink1-PA; L464P | Pink1-PF; L464P | Pink1-PB; L464P | Pink1-PI
L464P
Analogous mutation in human PINK1 implicated in Parkinson disease 6; mutation carried on in vitro construct; site of nucleotide substitution in fly gene and specific disease association inferred by FlyBase curator.
eye, with Scer\GAL4GMR.PF
The expression of Pink1L464P.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in clones within mosaic midguts during pupariation results in enterocytes exhibiting no significant changes in the relative mitochondrial content, as compared to non-clone enterocytes.
Flies expressing Pink1L464P.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF exhibit a rough eye phenotype and disarrayed ommatidia.
Pink1L464P.UAS.Tag:HA, Scer\GAL4GMR.PF has visible | adult stage phenotype, non-enhanceable by parkUAS.Tag:MYC, Scer\GAL4GMR.PF
Pink1L464P.UAS.Tag:HA, Scer\GAL4GMR.PF has visible | adult stage phenotype, non-suppressible by parkUAS.Tag:MYC, Scer\GAL4GMR.PF
Pink1L464P.UAS.Tag:HA, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by parkUAS.Tag:MYC, Scer\GAL4GMR.PF
Pink1L464P.UAS.Tag:HA, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by parkUAS.Tag:MYC, Scer\GAL4GMR.PF
Expression of parkScer\UAS.T:Hsap\MYC has no effect on the rough eye phenotype seen when Pink1L464P.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PF.
Pink1L464P.UAS.Tag:HA/Scer\GAL4hs.PB fails to rescue Pink1B9
Expressing Pink1L464P.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.PB fails to rescue the crushed thorax and downturned wing phenotypes seen in Pink1B9 mutant flies at three day post-eclosion. The mitochondrial defects, reduction in ATP levels and flightlessness are also still present. Expression of Pink1L464P.Scer\UAS.T:Ivir\HA1 fails to rescue the dopaminergic neuron loss seen in 45 day old Pink1B9 mutant flies.