FB2024_03 , released June 25, 2024
Allele: Dmel\parkUAS.Tag:MYC
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General Information
Symbol
Dmel\parkUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0191121
Feature type
allele
Associated gene
Dmel\park
Associated Insertion(s)
Carried in Construct
P{UAS-park-Myc}
Also Known As
UAS-parkin, UAS-parkinWT
Key Links
Transgenic product class
cDNA
(Cha et al., 2005)
wild_type
(Cha et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Cha et al., 2005)
wild_type
(Cha et al., 2005)
Mutagen
in vitro construct
(Cha et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-park-Myc}
Cytology
Description

UASt regulatory sequences drive expression of a wild-type full-length park cDNA with a Tag:MYC tag downstream.

(Cha et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
park
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF have normal eyes.

      (Song et al., 2013)

      Expression of parkScer\UAS.T:Hsap\MYC driven by Scer\GAL4ey.PU does not significantly affect eye morphology.

      (Koh et al., 2012)

      Expression of parkScer\UAS.T:Hsap\MYC driven by Scer\GAL4sev.PU does not result in obvious significant changes in the eye.

      (Hwang et al., 2010)

      Animals expressing parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR results in mitochondria of almost normal size in the adult thorax.

      (Park et al., 2009)

      Expression of parkScer\UAS.T:Hsap\MYC in the notum of wing imaginal discs (under the regulation of Scer\GAL4ap-md544) induces a marked cleft in the thorax, in a park-dose-dependent manner.

      (Cha et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      parkUAS.Tag:MYC, Scer\GAL4elav.PU is a suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HSPB3Y118H.UAS, Scer\GAL4elav.PU

      (Han et al., 2023)

      parkUAS.Tag:MYC, Scer\GAL4elav-C155 is a suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HSPB8K141E.UAS.cKa, Scer\GAL4elav-C155

      (Kang et al., 2023)

      parkUAS.Tag:MYC, Scer\GAL4elav-C155 is a suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HSPB8K141T.UAS.cKa, Scer\GAL4elav-C155

      (Kang et al., 2023)

      parkUAS.Tag:MYC, Scer\GAL4elav-C155 is a suppressor of decreased rate of adult walking behavior | progressive phenotype of Hsap\HSPB8K141T.UAS.cKa, Scer\GAL4elav-C155

      (Kang et al., 2023)

      parkUAS.Tag:MYC, Scer\GAL4elav.PU is a suppressor of viable phenotype of Pink1UAS.Tag:HA, Scer\GAL4elav.PU

      (Khalil et al., 2015)

      parkUAS.Tag:MYC/Scer\GAL4Bx-MS1096 is a suppressor of visible phenotype of Scer\GAL4Bx-MS1096, bskUAS.cBa

      (Hwang et al., 2010)

      Scer\GAL4sev.PU/parkUAS.Tag:MYC is a suppressor of visible phenotype of Scer\GAL4sev.PU, hepCA.UAS

      (Hwang et al., 2010)

      Scer\GAL4sev.PU/parkUAS.Tag:MYC is a suppressor of increased cell death | third instar larval stage phenotype of Scer\GAL4sev.PU, hepCA.UAS

      (Hwang et al., 2010)

      parkUAS.Tag:MYC/Scer\GAL4hs.PB is a suppressor | partially of flightless phenotype of Pink1B9

      (Park et al., 2006)

      parkUAS.Tag:MYC/Scer\GAL4hs.PB is a suppressor of abnormal locomotor behavior phenotype of Pink1B9

      (Park et al., 2006)
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      parkUAS.Tag:MYC, Scer\GAL4elav-C155 is a suppressor of larval ventral nerve cord phenotype of Hsap\HSPB8K141E.UAS.cKa, Scer\GAL4elav-C155

      (Kang et al., 2023)

      parkUAS.Tag:MYC, Scer\GAL4elav-C155 is a suppressor of mitochondrion | larval stage phenotype of Hsap\HSPB8K141E.UAS.cKa, Scer\GAL4elav-C155

      (Kang et al., 2023)

      parkUAS.Tag:MYC, Scer\GAL4elav-C155 is a suppressor of larval ventral nerve cord phenotype of Hsap\HSPB8K141T.UAS.cKa, Scer\GAL4elav-C155

      (Kang et al., 2023)

      parkUAS.Tag:MYC, Scer\GAL4elav-C155 is a suppressor of mitochondrion | larval stage phenotype of Hsap\HSPB8K141T.UAS.cKa, Scer\GAL4elav-C155

      (Kang et al., 2023)

      parkUAS.Tag:MYC/Scer\GAL4Bx-MS1096 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4Bx-MS1096, bskUAS.cBa

      (Hwang et al., 2010)

      Scer\GAL4sev.PU/parkUAS.Tag:MYC is a suppressor of eye phenotype of Scer\GAL4sev.PU, hepCA.UAS

      (Hwang et al., 2010)

      Scer\GAL4sev.PU/parkUAS.Tag:MYC is a suppressor of eye disc | third instar larval stage phenotype of Scer\GAL4sev.PU, hepCA.UAS

      (Hwang et al., 2010)

      Scer\GAL4ple.PF/parkUAS.Tag:MYC is a suppressor of mitochondrion & dopaminergic neuron phenotype of Pink1B9

      (Park et al., 2009)

      parkUAS.Tag:MYC/Scer\GAL4hs.PB is a suppressor | partially of mitochondrion phenotype of Pink1B9, park1

      (Kim et al., 2008)

      parkUAS.Tag:MYC/Scer\GAL4hs.PB is a suppressor of wing phenotype of Pink1B9

      (Park et al., 2006)

      parkUAS.Tag:MYC/Scer\GAL4hs.PB is a suppressor | partially of adult thorax phenotype of Pink1B9

      (Park et al., 2006)

      parkUAS.Tag:MYC/Scer\GAL4hs.PB is a suppressor of indirect flight muscle cell phenotype of Pink1B9

      (Park et al., 2006)

      parkUAS.Tag:MYC/Scer\GAL4hs.PB is a suppressor | partially of dopamine neuron & adult brain phenotype of Pink1B9

      (Park et al., 2006)

      Scer\GAL4ple.PF/parkUAS.Tag:MYC is a suppressor | partially of mitochondrion & dopamine neuron & adult brain phenotype of Pink1B9

      (Park et al., 2006)

      Scer\GAL4ap-md544, park[+], parkUAS.Tag:MYC is a suppressor of mesothoracic cleft | ectopic phenotype of Scer\GAL4ap-md544, Traf4EP578

      (Cha et al., 2005)
      NOT Suppressor of
      Other
      Statement
      Reference

      Pink1UAS.Tag:HA, Scer\GAL4hs.PB, parkUAS.Tag:MYC has mitochondrion & indirect flight muscle phenotype

      (Park et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Pink1Scer\UAS.T:Ivir\HA1 and parkScer\UAS.T:Hsap\MYC using Scer\GAL4elav.PU is deleterious as no adult flies emerge from pupae.

      (Khalil et al., 2015)

      Co-expression of parkScer\UAS.T:Hsap\MYC and Pink1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF results in lethality.

      Expression of parkScer\UAS.T:Hsap\MYC has no effect on the rough eye phenotype seen when Pink1K337R.D479A.D501A.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PF.

      Expression of parkScer\UAS.T:Hsap\MYC has no effect on the rough eye phenotype seen when Pink1G426D.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PF.

      Expression of parkScer\UAS.T:Hsap\MYC has no effect on the rough eye phenotype seen when Pink1L464P.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PF.

      (Song et al., 2013)

      Co-expression of parkScer\UAS.T:Hsap\MYC strongly suppresses the rough eye phenotype in flies and the increased cell death in third instar larval eye discs seen with expression of hepCA.Scer\UAS driven by Scer\GAL4sev.PU. Co-expression of parkScer\UAS.T:Hsap\MYC strongly suppresses the ectopic wing veins seen with expression of bskScer\UAS.cBa driven by Scer\GAL4Bx-MS1096.

      (Hwang et al., 2010)

      Co-expression of Pink1Scer\UAS.T:Ivir\HA1 and parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PB at 25[o]C results in pupal lethality, but at 18[o]C, several adult escapers are obtained. These escapers have smaller mitochondria in the indirect flight muscles compared to controls.

      Co-expression of parkScer\UAS.T:Hsap\MYC in adults expressing opa1-likeScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR results in smaller than normal mitochondria in the adult thorax.

      The swollen mitochondria phenotype seen in dopaminergic neurons of Pink1B9 mutants is suppressed by expression of parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4ple.PF.

      (Park et al., 2009)

      Expression of parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PB partially suppresses the mitochondrial swelling phenotype in Pink1B9, park1 double mutants.

      (Kim et al., 2008)

      Expression of parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PB markedly suppresses the downturned wing and crushed thorax phenotypes seen in Pink1B9 flies. The indirect flight muscle defects are also suppressed in these animals. The loss of dopaminergic neurons in the adult brain and the enlarged mitochondria phenotype seen in the remaining dopaminergic neurons is also significantly suppressed. The rescued flies show increased climbing speed and have some flight ability.

      (Park et al., 2006)

      Co-expression of Traf2EP1516, with parkScer\UAS.T:Hsap\MYC, in the notum of the wing imaginal discs, under the regulation of Scer\GAL4ap-md544 suppresses the parkScer\UAS.T:Hsap\MYC phenotype of thoracic cleft formation resulting from abnormalities in JNK signalling during thorax closure.

      (Cha et al., 2005)

      The thoracic cleft formation observed in parkScer\UAS.T:Hsap\MYC overexpression mutants (Scer\GAL4ap-md544) and bskK53R.Scer\UAS mutants is mutually enhanced by their co-expression. The thoracic cleft formation observed in parkScer\UAS.T:Hsap\MYC overexpression mutants (Scer\GAL4ap-md544) is suppressed by co-expression of bskScer\UAS.cBa. Overexpression of pucScer\UAS.cMa and parkScer\UAS.T:Hsap\MYC in the notum of the wing imaginal discs, under the regulation of Scer\GAL4ap-md544 enhances the thoracic cleft observed in each single overexpression. Expression of parkScer\UAS.T:Hsap\MYC in the notum of the wing imaginal discs, under the regulation of Scer\GAL4ap-md544, in hep1/+ mutants enhances the thoracic cleft phenotype observed in parkScer\UAS.T:Hsap\MYC/Scer\GAL4ap-md544 mutants alone. Co-expression of hepAct.Scer\UAS, with parkScer\UAS.T:Hsap\MYC, in the notum of the wing imaginal discs, under the regulation of Scer\GAL4ap-md544 suppresses the parkScer\UAS.T:Hsap\MYC phenotype of thoracic cleft formation resulting from abnormalities in JNK signalling during thorax closure. The thoracic cleft formation observed in parkScer\UAS.T:Hsap\MYC overexpression mutants (Scer\GAL4ap-md544) is suppressed by co-expression of Traf1EP578. Overexpression of pucScer\UAS.cMa and parkScer\UAS.T:Hsap\MYC in the notum of wing imaginal discs, under the regulation of Scer\GAL4ap-md544 enhances the thoracic cleft observed in each single overexpression. Overexpression of Pk92BScer\UAS.T:Zzzz\FLAG and parkScer\UAS.T:Hsap\MYC in the notum of wing imaginal discs, under the regulation of Scer\GAL4ap-md544 partially suppresses the thoracic cleft observed in parkScer\UAS.T:Hsap\MYC mutants. The thoracic cleft formation observed in parkScer\UAS.T:Hsap\MYC overexpression mutants (Scer\GAL4ap-md544) is enhanced by co-expression of Pk92BK618M.Scer\UAS.

      (Cha et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      parkUAS.Tag:MYC rescues park1

      (Kim et al., 2008)

      parkUAS.Tag:MYC/Scer\GAL4Ddc.PL rescues park1

      (Cha et al., 2005)
      Comments

      The mitochondrial morphology in the indirect flight muscle of park1 mutants is fully rescued by expression of parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PB

      (Kim et al., 2008)

      The park1 dorsomedial dopaminergic neuron morphology and loss phenotype can be completely rescued by the expression of parkScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Ddc.PL.

      (Cha et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      parkScer\UAS.T:Hsap\MYC
      parkUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (12)