FlyBase Allele Report: Dmel\so[FL.UAS]

General Information

Symbol

Dmel\so^FL.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0285829

Feature type

allele

Associated gene

Dmel\so

Associated Insertion(s)

Carried in Construct

P{UAS-so.FL}

Also Known As

UAS-so

Key Links

Transgenic product class

wild_type

(Weasner et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Weasner et al., 2007)

Mutagen

in vitro construct

(Weasner et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-so.FL}

Cytology

Description

UASt regulates expression of full-length so.

(Weasner et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ey.PU

(Anderson et al., 2012)

visible, with Scer\GAL4^GMR.PU

(Anderson et al., 2012)

Phenotype Manifest In

adult head, with Scer\GAL4^cb49

(Weasner et al., 2007)

adult head, with Scer\GAL4^sd.PU

(Weasner et al., 2007)

antenna, with Scer\GAL4^cb41

(Weasner et al., 2007)

antenna, with Scer\GAL4^cb49

(Weasner et al., 2007)

antenna, with Scer\GAL4^dpp.PU

(Weasner et al., 2007)

eye, with Scer\GAL4^ey.PU

(Anderson et al., 2012)

eye, with Scer\GAL4^GMR.PU

(Anderson et al., 2014, Anderson et al., 2012, Weasner and Kumar, 2009)

eye | ectopic, with Scer\GAL4^cb41

(Weasner et al., 2007)

eye | ectopic, with Scer\GAL4^cb49

(Weasner et al., 2007)

eye | ectopic, with Scer\GAL4^dpp.PU

(Weasner et al., 2007)

eye | ectopic, with Scer\GAL4^sd.PU

(Weasner et al., 2007)

wing, with Scer\GAL4^rn-GAL4-5

(Weasner et al., 2007)

Detailed Description

Statement

Reference

Scer\GAL4^GMR.PU-mediated expression of so^FL.Scer\UAS leads to a severe roughening of the eye - defects are most severe in the posterior third of the eye where the eye appears devoid of ommatidia.

(Anderson et al., 2014)

Expression of so^FL.Scer\UAS under the control of Scer\GAL4^ey.PU results in a smaller eye than normal. The remaining ommatidia have relatively normal numbers of photoreceptors and positioning.

Expression of so^FL.Scer\UAS under the control of Scer\GAL4^GMR.PU results in a severe roughening of the anterior half of the eye and almost complete elimination of retinal tissue in the posterior half.

(Anderson et al., 2012)

Scer\GAL4^GMR.PU-mediated expression of so^FL.Scer\UAS moderately inhibits eye development.

(Weasner and Kumar, 2009)

Expression of so^FL.Scer\UAS via Scer\GAL4^dpp.PU, Scer\GAL4^cb41, Scer\GAL4^cb49 or Scer\GAL4^sd.PU yields ectopic eyes on either the adult antenna or the ventral portion of the head.

Expression of so^FL.Scer\UAS via Scer\GAL4^rn-GAL4-5 causes the wing to shrink in size and have patterning defects, however retinal tissue is not induced.

Expression of so^FL.Scer\UAS via Scer\GAL4^ey.PU or Scer\GAL4^GMR.PU has only a minor effect on the development and structure of the eye.

(Weasner et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, so^FL.UAS has eye phenotype, enhanceable by eya^UAS.cBa/Scer\GAL4^GMR.PU

(Anderson et al., 2014)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, so^FL.UAS has eye phenotype, non-enhanceable by fl(2)d^UAS.cAa/Scer\GAL4^GMR.PU

(Anderson et al., 2014)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, so^FL.UAS has eye phenotype, suppressible | partially by fl(2)d^GD11887/Scer\GAL4^GMR.PU

(Anderson et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, so^FL.UAS has eye phenotype, non-suppressible by fl(2)d^f01270/fl(2)d[+]

(Anderson et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

so^FL.UAS/Scer\GAL4^ey.PU rescues so¹

(Weasner et al., 2007)

Partially rescues

so^FL.UAS/Scer\GAL4^ey.PU partially rescues so^D

(Weasner et al., 2007)

Comments

Scer\GAL4^ey.PU-mediated expression of so^FL.Scer\UAS restores so¹ eyes to near wild type.

Scer\GAL4^ey.PU-mediated expression of so^FL.Scer\UAS partially restores so^D eyes.

(Weasner et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

so^FL.Scer\UAS

so^FL.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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