FB2024_03 , released June 25, 2024
Allele: Dmel\insbUAS.GFP
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General Information
Symbol
Dmel\insbUAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0296585
Feature type
allele
Associated gene
Dmel\insb
Associated Insertion(s)
Carried in Construct
P{UAS-insb.GFP}
Key Links
Transgenic product class
wild_type
(Coumailleau and Schweisguth, 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Coumailleau and Schweisguth, 2014)
Mutagen
in vitro construct
(Coumailleau and Schweisguth, 2014)
Progenitor genotype
Carried in construct
P{UAS-insb.GFP}
Cytology
Description

UASt regulatory sequences drive expression of the insb open reading frame amplified from wild-type DNA.

(Coumailleau and Schweisguth, 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
insb
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of insbT:Avic\GFP under the control of Scer\GAL4sd.PU results in loss of wing margin.

      Expression of insbScer\UAS.T:Avic\GFP under the control of Scer\GAL4pnr.PU leads to bristle loss (associated with a transformation of external cells into internal cells) and bristle tufts (due to an excess of SOPs). The bristle loss phenotype is associated with an increased density of sensory organs in the dorso-central region of the notum and a transformation of sense organ cells into neurons.

      (Coumailleau and Schweisguth, 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4sd.PU, insbUAS.GFP has visible | adult stage phenotype, non-suppressible by insv23B

      (Coumailleau and Schweisguth, 2014)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4sd.PU, insbUAS.GFP has wing phenotype, non-suppressible by insv23B

      (Coumailleau and Schweisguth, 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      insv23B does not suppress the wing defects seen when insbScer\UAS.T:Avic\GFP is expressed under the control of Scer\GAL4sd.PU.

      (Coumailleau and Schweisguth, 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      insbScer\UAS.T:Avic\GFP
      insbUAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)