FB2024_03 , released June 25, 2024
Allele: Dmel\CG46339ΔCAT.UASp.Tag:HA
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General Information
Symbol
Dmel\CG46339ΔCAT.UASp.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0319364
Feature type
allele
Associated gene
Dmel\CG46339
Associated Insertion(s)
Carried in Construct
P{UASp-HA-CG46339.ΔCAT}
Key Links
Transgenic product class
inframe_deletion
(Lim et al., 2015)
loss_of_function_variant
(Lim et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Lim et al., 2015)
loss_of_function_variant
(Lim et al., 2015)
Mutagen
in vitro construct
(Lim et al., 2015)
Progenitor genotype
Carried in construct
P{UASp-HA-CG46339.ΔCAT}
Cytology
Description

UASp regulatory sequences drive expression of CG46339 lacking the catalytic domain (resulting in an enzymatically inactive form of the protein). The protein is tagged at the N-terminal end with Tag:HA.

(Lim et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
CG46339
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of sdaΔCAT.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4upd1.PU fails to restore the ability of sdaiso7.8/Df(3R)ED6235 mutants to undergo spermatogonial dedifferentiation and recover germline stem cell number in the testicular niche after expression of bamhs.PO via heat shock treatment.

      (Lim et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      CG46339ΔCAT.UASp.Tag:HA/Scer\GAL4upd1.PU fails to rescue Df(3R)ED6235/jusiso7.8

      (Lim et al., 2015)
      Comments

      Expression of sdaΔCAT.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4upd1.PU fails to rescue the testicular niche phenotypes of sdaiso7.8/Df(3R)ED6235 mutants.

      (Lim et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG46339ΔCAT.Scer\UAS.P\T.T:Ivir\HA1
      CG46339ΔCAT.UASp.Tag:HA
      sdaΔCAT.Scer\UAS.P\T.T:Ivir\HA1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)