FB2024_03 , released June 25, 2024
Allele: Dmel\parkUAS.Tag:FLAG
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General Information
Symbol
Dmel\parkUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0319979
Feature type
allele
Associated gene
Dmel\park
Associated Insertion(s)
Carried in Construct
P{UAS-park.flag}
Key Links
Transgenic product class
wild_type
(Huang et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Huang et al., 2016)
Mutagen
in vitro construct
(Huang et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-park.flag}
Cytology
Description

UAS drives expression of Tag:FLAG-tagged park.

(Huang et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
park
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by trpP365
      (Huang et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Co-expression (but not single expression of either construct) of parkScer\UAS.T:Zzzz\FLAG and Pink1Scer\UAS.T:Ivir\HA1 ameliorates neurodegenerative disease modeled by trpP365.

      (Huang et al., 2016)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Pink1Scer\UAS.T:Ivir\HA1 or parkScer\UAS.T:Zzzz\FLAG driven by Scer\GAL4GMR.PF does not suppress age-dependent retinal degeneration (loss of rhabdomeres from photoreceptors) in trpP365/+ flies; co-expression of both Pink1Scer\UAS.T:Ivir\HA1 and parkScer\UAS.T:Zzzz\FLAG results in significant partial suppression of the phenotype.

      (Huang et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      parkScer\UAS.T:Zzzz\FLAG
      parkUAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)