FB2024_03 , released June 25, 2024
Allele: Dmel\Sec71UAS.RR
Open Close
General Information
Symbol
Dmel\Sec71UAS.RR
Species
D. melanogaster
Name
FlyBase ID
FBal0326754
Feature type
allele
Associated gene
Dmel\Sec71
Associated Insertion(s)
Carried in Construct
P{UAS-Sec71.RR}
Key Links
Transgenic product class
wild_type
(Wang et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wang et al., 2017)
Mutagen
in vitro construct
(Wang et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Sec71.RR}
Cytology
Description

UAS regulatory sequences drive expression of the wild-type Sec71 protein. The construct has been engineered to be resistant to the Sec71HMS00357 RNA line.

(Wang et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sec71
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4ppk.PU/Sec71UAS.RR rescues Sec71HMS00357

      (Wang et al., 2017)

      Scer\GAL4elav.PU/Sec71UAS.RR rescues Sec71Ex11

      (Wang et al., 2017)
      Comments

      The co-expression of Sec71Scer\UAS.RNAi-resistant fully rescues both the dendritic arborization defects at the white pupa stage and the dendrite pruning defects at 16h after puparium formation observed in dorsal multidendritic ddaC neurons resulting from the expression of Sec71HMS00357 under the combined control of Scer\GAL4ppk.PU and Dicer-2 transgene; clonal expression under the control of Scer\GAL4elav.PU rescues the defects in dendrite pruning at 16h after puparium formation observed in clonal Sec71Ex11-homozygous dorsal multidendritic ddaC neurons.

      (Wang et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sec71Scer\UAS.RNAi-resistant
      Sec71UAS.RNAi-resistant
      Sec71UAS.RR
      Name Synonyms
      Secondary FlyBase IDs
        References (5)