FB2024_03 , released June 25, 2024
Allele: Dmel\Cpsf5UAS.B.Tag:HA,Tag:FLAG
Open Close
General Information
Symbol
Dmel\Cpsf5UAS.B.Tag:HA,Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0327308
Feature type
allele
Associated gene
Dmel\Cpsf5
Associated Insertion(s)
Carried in Construct
M{UAS-Cpsf5.B.HA.FLAG}
Key Links
Transgenic product class
cDNA
(Shan et al., 2017)
wild_type
(Shan et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Shan et al., 2017)
wild_type
(Shan et al., 2017)
Mutagen
in vitro construct
(Shan et al., 2017)
Progenitor genotype
Carried in construct
M{UAS-Cpsf5.B.HA.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of isoform B of CG3689 (DGRC clone UFO03148); tagged with Tag:HA and Tag:FLAG.

(Shan et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Cpsf5
Tagged with
Tag:FLAG
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CG3689Scer\UAS.B.T:Ivir\HA1,T:Zzzz\FLAG under the control of Scer\GAL4bam.T:Hsim\VP16 results in highly penetrant tumorigenic phenotype due to spermatogonial overgrowth in adult testes.

      (Shan et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Cpsf5UAS.B.Tag:HA,Tag:FLAG/Scer\GAL4VP16.bam is an enhancer of neoplasia | adult stage | male phenotype of tut4

      (Shan et al., 2017)
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The moderate spermatogonial tumor phenotype (with large tumors, >1/6 of overall testis length, being very rare) observed in testes of tut4 homozygous mutant males is enhanced by Scer\GAL4bam.T:Hsim\VP16-driven expression of CG3689Scer\UAS.B.T:Ivir\HA1,T:Zzzz\FLAG in the mutant background and the proportion of large tumors reaches >40%.

      (Shan et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG3689Scer\UAS.B.T:Ivir\HA1,T:Zzzz\FLAG
      CG3689UAS.B.Tag:HA,Tag:FLAG
      Cpsf5UAS.B.Tag:HA,Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)