UAS regulatory sequences drive expression of Hsap\SMARCA5 that has been mutated to carry the p.(Arg592Gln) variant. This variant has previously been identified in an individual with a neurodevelopmental disorder.
Expressing Hsap\SMARCA5R592Q.UAS under the control of Scer\GAL4ppk.PG leads to third instar larval C4da neurons with decreased dendrite complexity (decreased dendrite length and branch number).
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a suppressor | partially of decreased body size | third instar larval stage phenotype of Iswi2
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a suppressor | partially of visible | third instar larval stage phenotype of Iswi2
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Iswi2
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a non-suppressor of decreased occurrence of cell division | third instar larval stage phenotype of Iswi2
Hsap\SMARCA5R592Q.UAS, Scer\GAL4elav.PU is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of IswiHMS00628, Scer\GAL4elav.PU
Hsap\SMARCA5R592Q.UAS, Scer\GAL4elav.PU is a non-suppressor of decreased size | adult stage phenotype of IswiHMS00628, Scer\GAL4elav.PU
Hsap\SMARCA5R592Q.UAS, Scer\GAL4elav.PU is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of IswiHMS00628, Scer\GAL4elav.PU
Hsap\SMARCA5R592Q.UAS, IswiHMS00628, Scer\GAL4elav.PU has short lived phenotype
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a suppressor | partially of embryonic/larval brain | third instar larval stage phenotype of Iswi2
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a non-suppressor of larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype of Iswi2
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a non-suppressor of larval ventral multidendritic neuron vdaA | third instar larval stage phenotype of Iswi2
Scer\GAL4Act5C.PU/Hsap\SMARCA5R592Q.UAS is a non-suppressor of dendrite | third instar larval stage phenotype of Iswi2
Hsap\SMARCA5R592Q.UAS, Scer\GAL4elav.PU is a non-suppressor of medial lobe of adult mushroom body phenotype of IswiHMS00628, Scer\GAL4elav.PU
Hsap\SMARCA5R592Q.UAS, Scer\GAL4elav.PU is a non-suppressor of mushroom body vertical lobe | adult stage phenotype of IswiHMS00628, Scer\GAL4elav.PU