FB2024_03 , released June 25, 2024
Allele: Dmel\XpdRNAi.UAS.012.2
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General Information
Symbol
Dmel\XpdRNAi.UAS.012.2
Species
D. melanogaster
Name
FlyBase ID
FBal0367710
Feature type
allele
Associated gene
Dmel\Xpd
Associated Insertion(s)
Carried in Construct
P{UAS-MYBΔC,UAS-3sh(Xpd,ft,kug).012.2}
Key Links
Transgenic product class
RNAi_reagent
(Bangi et al., 2021)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Bangi et al., 2021)
Mutagen
in vitro construct
(Bangi et al., 2021)
Progenitor genotype
Carried in construct
P{UAS-MYBΔC,UAS-3sh(Xpd,ft,kug).012.2}
Cytology
Description

A multigenic construct that expresses a a truncated Hsap\MYB protein and a hairpin cluster, each downstream of their own inducible UAS promoter. The truncated Hsap\MYB protein was found in a patient with adenoid cystic carcinoma - it lacks the C-terminal cytoplasmic domain required to regulate Hsap\MYB activity. The hairpin cluster (version 12.2) targets orthologs of human ERCC2, FAT4, and FAT1/3 (Xpd, ft and kug, respectively), which harbored misssense mutations in the patient's tumor.

(Bangi et al., 2021)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Xpd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The expression of Hsap\MYBΔC.UAS, XpddsRNA.UAS.012.2, ftdsRNA.UAS.012.2 and kugdsRNA.UAS.012.2 under the control of Scer\GAL4ptc-559.1 induces an expansion of the ptc-positive domain of the wing disc's anterior/posterior boundary and a loss of the sharp boundary.

      (Bangi et al., 2021)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      XpdRNAi.UAS.012.2
      XpddsRNA.UAS.012.2
      Name Synonyms
      Secondary FlyBase IDs
        References (3)