UASt regulatory sequences drive expression of the Hsap\TMEM208 open reading frame, mutated to carry the L27P amino acid replacement, a variant identified in a patent with global developmental delay and a multisystemic disorder. The coding sequence is tagged at the C-terminal end with three copies of Tag:HA. The human ORF is flanked by a pair of incompatible FRT sites (FRT5 and FRT2), which allows for future in vivo exchange of either the promoter or tag sequence.
Hsap\TMEM208L27P.UAS.Tag:HA/Scer\GAL4Tmem208-CR70040-KO-kG4 is a suppressor | partially of increased mortality during development phenotype of Df(2R)Exel7138/Tmem208CR70040-KO-kG4
Hsap\TMEM208L27P.UAS.Tag:HA/Scer\GAL4Tmem208-CR70040-KO-kG4 is a suppressor | partially of abnormal planar polarity | adult stage phenotype of Df(2R)Exel7138/Tmem208CR70040-KO-kG4
Hsap\TMEM208L27P.UAS.Tag:HA/Scer\GAL4Tmem208-CR70040-KO-kG4 is a suppressor | partially of wing hair phenotype of Df(2R)Exel7138/Tmem208CR70040-KO-kG4