KMO
Please see the JBrowse view of Dmel\cn for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Mutation in sequenced strain: deletion (removes 3' end); see allele report cn[1].
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
2.2, 1.8 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
524 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cn using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
The 1.8 and 2.2 kb cn transcripts are detected in mid-larval through pupal stages, with the highest levels in mid-pupal stages. No expression is detected in newly emerged adults. The 1.8 kb transcript is dominant in larvae, while the 2.2 kb transcript is dominant in pupae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\cn in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
A modified Dmau\mariner element marked with a wild-type allele of cn is capable of mediating germ-line transformation of A.aegypti.
Cloning and characterisation of the cn region.
Lesions in cn block pigmentation in the eye, ocelli, tubule and fat body.
Heterozygotes in all pairwise combinations of 13 EMS-induced alleles exhibit mutant phenotype. Ethyl methanesulfonate-induced mutants can be recovered as mosaics in homozygous red background.
cn mutants are defective in the uptake of kynurenine by eye discs and Malpighian tubules, where it is normally converted to 3-hydroxykynurenine.
Kynurenine 3-hydroxylase activity proportional to the number of doses of cn+; cn+ therefore concluded to be the structural gene for the enzyme. Enzyme activity is developmentally regulated with a peak of activity in early third instar and a five-fold higher peak in the second half of pupal development.
cn homozygotes are devoid of kynurenine 3-hydroxylase activity.
Larval Malpighian tubes are pale yellow.
Nonautonomous in development of pigment of transplanted eye discs.
The white eye colour of the A.aegypti khw mutant (caused by a mutation in Aaeg\KH) is partially complemented by D.melanogaster cn. The cn gene acts in a semi-dominant manner.
Source for identity of: cn CG1555