l(2)ND2, dynamin-2, l(2)ND3, Drp-1, noodle
a Dynamin GTPase - regulates mitochondrial fission in normal cells including primary spermatocytes - mediates mitochondrial fragmentation during programmed cell death
Please see the JBrowse view of Dmel\Drp1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drp1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Drp1 in JBrowse2-7
2-5.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Drp1 is required for the normal distribution of mitochondria in spermatocytes and the normal unfurling of the mitochondrial derivatives in early spermatids during sperm formation.
Drp1 is required for normal mitochondrial distribution and morphology in all cells tested.
Mutants show a defect in the formation and recruitment of the synaptic vesicle reserve pool.
Drp1 is required for the proper cellular distribution of mitochondria.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
Required at the neuromuscular junction.
Mutants show a distinct temperature sensitive paralysis phenotype.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Source for merge of: Drp1 dynamin-2 noodle l(2)22Fc l(2)22Fd
'CG3210', 'Drp1' and 'dynamin-2' may all correspond to the same gene.
Source for identity of: noodle CG3210
The gene is named "fratboy" after the mutant phenotype; adult escaper flies are uncoordinated and show numerous neurological defects.
