VDAC, VDAC1, l(2)k05123, DmVDAC, POR-1
main pore-forming protein of the outer mitochondrial membrane - multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions
Please see the JBrowse view of Dmel\porin for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
282 (aa)
Interacts with hexokinases.
Ubiquitinated (PubMed:32047033). Undergoes monoubiquitination and polyubiquitination by park; monoubiquitination at Lys-273 inhibits apoptosis, whereas polyubiquitination at Lys-11, Lys-19, Lys-52 and Lys-109 may promote mitophagy (PubMed:32047033).
Consists mainly of membrane-spanning sided beta-sheets.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\porin using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
porin transcripts are abundant in both testis and ovary
Three transcript sizes observed on Northern Blot. Sizes were not reported.
JBrowse - Visual display of RNA-Seq signals
View Dmel\porin in JBrowse2-43
2-36.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
porin encodes a voltage-dependent and anion-selective channel.
porin has been cloned and sequenced. It has been isolated from an expression library using an antibody against tobacco hornworm VDAC protein as a probe. Comparison of DNA sequence with that from FBrf0087605 reveals there is one porin gene, and two isolated cDNAs.
porin has been characterised and compared to other mitochondrial porins.
Source for merge of: porin l(2)k05123
Source for merge of: porin anon-WO02059370.56
Source for merge of porin anon-WO02059370.56 was sequence comparison ( date:051113 ).
Source for identity of: porin CG6647