Please see the JBrowse view of Dmel\halo for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\halo using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Low levels of halo expression can be detected starting in embryonic cycle 13. Levels are very high starting in cycle 14 before nuclear elongation. During nuclear elongation the signal faded in a dorsal-ventral pattern and then dropped precipitously after the invaginating membrane reached the tips of the nuclei. Expression persisted at a low levels as development proceeded.
JBrowse - Visual display of RNA-Seq signals
View Dmel\halo in JBrowse2-3
2-2.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
halo controls two transitions in lipid droplet transport in the early embryo; synthesis of halo protein promotes the phase-I to phase-IIa transition, and loss of halo protein is necessary for the phase-IIa to phase-IIb-phase-III transition. halo protein may act as a rate-limiting cofactor of kinesin-1.
In embryos injected with dsRNA made from templates generated with primers directed against this gene the cytoplasm does not clear lipid droplets during cellularisation. The apical cytoplasm is consequently opaque.
halo is a regulator of lipid droplet transport in early embryos.
Source for merge of: halo CG7428