FlyBase Gene Report: Dmel\Septin2

General Information

Symbol

Dmel\Septin2

Species

D. melanogaster

Name

Septin 2

Annotation Symbol

CG4173

Feature Type

protein_coding_gene

FlyBase ID

FBgn0014029

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Involved in cytokinesis. (UniProt, P54359)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Sep2, septin

Key Links

Genomic Location

Cytogenetic map

92F2-92F2

Sequence location

3R:20,586,129..20,588,356 [-]

Recombination map

3-69

RefSeq locus

NT_033777 REGION:20586129..20588356

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables GTPase activity

inferred from direct assay

(Field et al., 1996)

enables protein binding

inferred from physical interaction with FLYBASE:sip2; FB:FBgn0031878

(Shih et al., 2002)

enables protein homodimerization activity

inferred from direct assay

(Field et al., 1996)

NOT enables GTPase activity

inferred from direct assay

(Akhmetova et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables GTP binding

inferred from electronic annotation with InterPro:IPR016491, InterPro:IPR030379

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from sequence or structural similarity with FLYBASE:pnut; FB:FBgn0013726

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

enables molecular adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in growth of a germarium-derived egg chamber

inferred from mutant phenotype

(O'Neill and Clark, 2013)

involved_in imaginal disc development

inferred from genetic interaction with FLYBASE:Septin5; FB:FBgn0026361

(O'Neill and Clark, 2013)

involved_in regulation of cell cycle

inferred from genetic interaction with FLYBASE:Septin5; FB:FBgn0026361

(O'Neill and Clark, 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cellularization

traceable author statement

(Mazumdar and Mazumdar, 2002)

involved_in cytoskeleton-dependent cytokinesis

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

involved_in protein localization

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of septin complex

inferred from physical interaction with FLYBASE:Septin1; FB:FBgn0011710,FLYBASE:pnut; FB:FBgn0013726

(Field et al., 1996)

inferred from physical interaction with FLYBASE:pnut; FB:FBgn0013726,FLYBASE:Septin2; FB:FBgn0014029

(Akhmetova et al., 2015)

inferred from direct assay

(Huijbregts et al., 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in cell division site

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

is_active_in microtubule cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

part_of septin complex

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

is_active_in septin ring

inferred from biological aspect of ancestor with PANTHER:PTN000430171

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SEPTINS

Protein Family (UniProt)

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (P54359)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Group (FlyBase)

SEPTINS -: Septins are a family of GTPases which can polymerize to form filaments. Septins are involved in a variety of processes including cytokinesis and trafficking. (Adapted from FBrf0216213).

Protein Function (UniProtKB)

Involved in cytokinesis.

(UniProt, P54359)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Septin2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P54359)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

8DKT

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Septin2-RA

FBtr0083945

NM_079693

1562

419

Septin2-RB

FBtr0334579

NM_001275835

1688

360

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Septin2-PA

FBpp0083352

48.5

419

7.67

FBpp0306646

42.0

360

7.92

A0A0B4KGJ1

NP_001262764

AGB96144

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

May assemble into a multicomponent structure.

(UniProt, P54359)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

8DKT

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Septin2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sep2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.21

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 1 -- 16

organism | ubiquitous

(O'Neill and Clark, 2013)

embryonic stage 4 -- 6

head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 14 -- 16

embryonic/larval somatic muscle cell

(O'Neill and Clark, 2013)

Additional Descriptive Data

Septin2 is expressed ubiquitously during embryogenesis with stronger staining in somatic muscle in late embryos. The expression pattern was compared to that of other Drosophila species.

(O'Neill and Clark, 2013)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of septin complex

inferred from physical interaction with FLYBASE:Septin1; FB:FBgn0011710,FLYBASE:pnut; FB:FBgn0013726

(Field et al., 1996)

inferred from physical interaction with FLYBASE:pnut; FB:FBgn0013726,FLYBASE:Septin2; FB:FBgn0014029

(Akhmetova et al., 2015)

inferred from direct assay

(Huijbregts et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Septin2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Septin2

View exonic expression by tissue for Dmel\Septin2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0014029

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42438/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014029

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014029

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014029

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4173

Flygut - An atlas of the Drosophila adult midgut

FBgn0014029

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Septin2

Transgenic constructs containing regulatory region of Septin2

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Septin2^GD11240

partially lethal (with Septin2¹)

Septin2²

partially lethal (with Septin2²)

Septin2¹

partially lethal | maternal effect

partially lethal | paternal effect

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Septin2^GD11240

viable, with Scer\GAL4^Mef2.PR

Septin2^GD11240

viable, with Scer\GAL4^pnr-MD237

Septin2^GD11240

viable, with Scer\GAL4^tin.CΔ4

Septin2^GD11240

Sterility

Allele

female semi-sterile

fertile

Septin2^EY05856

male semi-sterile

Other Phenotypes

Allele

abnormal cell cycle

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Septin2^GD11240

some die during pharate adult stage (with Septin2¹)

Septin2²

some die during pharate adult stage (with Septin2²)

Septin2¹

visible, with Scer\GAL4^pnr-MD237

Septin2^GD11240

Phenotype manifest in

Allele

egg | maternal effect

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Septin2^GD11240

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Septin2^GD11240

nurse cell

trichogen cell, with Scer\GAL4^pnr-MD237

Septin2^GD11240

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\SEPTIN6

14 of 14

Yes

Hsap\SEPTIN8

13 of 14

Yes

Hsap\SEPTIN11

13 of 14

Yes

Hsap\SEPTIN10

12 of 14

Hsap\SEPTIN14

9 of 14

Yes

Hsap\SEPTIN3

5 of 14

Yes

Hsap\SEPTIN5

4 of 14

Hsap\SEPTIN9

4 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Hsap\SEPT5-GP1BB

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Septin6

14 of 14

Yes

Rnor\Septin8

13 of 14

Yes

Rnor\Septin11

13 of 14

Yes

Rnor\Septin10

11 of 14

Rnor\Septin14

8 of 14

Yes

Rnor\Septin3

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\LOC102550225

1 of 14

Yes

Mus musculus (laboratory mouse) (15)

Mmus\Septin6

14 of 14

Yes

Mmus\Septin8

13 of 14

Yes

Mmus\Septin11

13 of 14

Yes

Mmus\Septin10

12 of 14

Mmus\Septin14

8 of 14

Yes

Mmus\Septin3

4 of 14

Yes

Mmus\Septin4

4 of 14

Mmus\Septin5

4 of 14

Mmus\Septin9

4 of 14

Yes

4 of 14

3 of 14

3 of 14

2 of 14

1 of 14

Yes

Mmus\Tmem250-ps

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (17)

Xtro\septin8

9 of 13

Yes

Xtro\septin6

8 of 13

Yes

7 of 13

6 of 13

5 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (30)

Drer\sept6

14 of 14

Yes

Drer\sept8a

13 of 14

Yes

Drer\sept8b

13 of 14

Yes

Drer\sept10

11 of 14

Drer\sept3

5 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

Yes

Drer\si:ch73-170d6.2

1 of 14

Yes

Drer\si:ch211-282j17.12

1 of 14

Yes

Drer\si:ch211-282j17.13

1 of 14

Yes

Drer\si:ch211-285c6.1

1 of 14

Yes

Drer\si:ch211-285c6.4

1 of 14

Yes

Drer\si:dkey-88n24.11

1 of 14

Yes

Drer\si:dkey-187j14.1

1 of 14

Yes

Drer\si:dkey-187j14.4

1 of 14

Yes

Drer\zgc:66473

1 of 14

Yes

Drer\zgc:172065

1 of 14

Yes

Drer\zgc:195077

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\unc-61

13 of 14

Yes

Cele\unc-59

3 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP011532

12 of 12

Yes

Agam\AgaP_AGAP000768

3 of 12

Agam\AgaP_AGAP002645

3 of 12

Agam\AgaP_AGAP007596

3 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\TOC120

1 of 13

Yes

Atha\TOC132

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\CDC12

4 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Schizosaccharomyces pombe (Fission yeast) (7)

Spom\spn4

4 of 12

Yes

Spom\spn6

4 of 12

Yes

Spom\spn1

3 of 12

Spom\spn2

3 of 12

Yes

Spom\spn3

3 of 12

Spom\spn7

3 of 12

Spom\spn5

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Septin2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

11 of 13

6 of 13

5 of 13

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SEPTIN9; septin 9

model of amyotrophic neuralgia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

14 of 14

13 of 14

13 of 14

12 of 14

9 of 14

5 of 14

4 of 14

4 of 14

AMYOTROPHY, HEREDITARY NEURALGIC; HNA

amyotrophic neuralgia

SEPTIN12; septin 12

4 of 14

611562

SPERMATOGENIC FAILURE 10; SPGF10

spermatogenic failure 10

3 of 14

3 of 14

3 of 14

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Septin2 - Dlip2

two hybrid

(Shih et al., 2002)

Septin2 - HIP-R

experimental knowledge based

(Guruharsha et al., 2011)

Septin2 - Septin1

experimental knowledge based, anti tag coimmunoprecipitation, western blot, pull down, peptide massfingerprinting, two hybrid, cosedimentation, molecular weight estimation by staining, molecular sieving

(Deb and Hasan, 2019, Mavrakis et al., 2014, Guruharsha et al., 2011, Shih et al., 2002, Field et al., 1996)

Septin2 - Septin5

experimental knowledge based

(Guruharsha et al., 2011)

Septin2 - Uba2

two hybrid

(Shih et al., 2002)

Septin2 - ft

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Kwon et al., 2013, Kwon et al., 2013)

Septin2 - lwr

two hybrid

(Shih et al., 2002)

Septin2 - sau

anti bait coimmunoprecipitation, western blot

(Sechi et al., 2014)

Septin2 - scra

anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, western blot

(D'Avino et al., 2008, Silverman-Gavrila et al., 2008)

Septin2 - sip2

two hybrid

(Shih et al., 2002)

Septin2 - sip3

two hybrid

(Shih et al., 2002)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

shot

suppressible

Septin2

(Sun et al., 2019)

External Data

Subunit Structure (UniProtKB)

May assemble into a multicomponent structure.

(UniProt, P54359 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67416

DroID - A comprehensive database of gene and protein interactions.

FBgn0014029

MIST (protein-protein) - An integrated Molecular Interaction Database

42438

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-69

Cytogenetic map

92F2-92F2

Sequence location

3R:20,586,129..20,588,356 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

92F2-92F2

Limits computationally determined from genome sequence between P{PZ}l(3)10585¹⁰⁵⁸⁵ and P{EP}Synd^EP409

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

92E8-92E9

(Al-Awar, 1995.6.12)

Experimentally Determined Recombination Data

Location

3-69

(FlyBase, 2016)

3-72.8

(Comeron et al., 2012)

(Al-Awar, 1995.6.12)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

91012

w^*; P{UASp-Septin2.O}18A/CyO

26257

y¹ w^*; P{Septin2-GFP.SG}3

28004

y¹ v¹; P{TRiP.JF02838}attP2

91002

w^*; Septin2¹/TM6B, Tb¹

91003

w^*; Septin2²/TM6B, Tb¹

16680

y¹ w^67c23; P{EPgy2}Septin2^EY05856

85837

y¹ sc^* v¹ sev²¹; P{TKO.GS04058}attP40

91014

w^*; Septin5²; Septin2²/T(2;3)TSTL, CyO: TM6B, Tb¹

16305

y¹ w¹¹¹⁸; PBac{3HPy⁺}Septin2^C207/TM3, Sb¹ Ser¹

VDRC

v110652

P{KK108455}VIE-260B

v26413

w¹¹¹⁸; P{GD11240}v26413

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (158)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD20082

Other clones

DPiM_LD20082

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0014029

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0014029

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Akhmetova et al., 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against Sep2 that is transfected into S2 treated with Listeria monocytogenes reveals Sep2 to be involved in Listeria monocytogenes entry and intracellular growth.

(Cheng et al., 2005)

dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

(Echard et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila Septin 2 gene, Acc. No. U28966.

(Davies, 2001.3.15)

A complex of septin polypeptides is isolated that bind and hydrolyse GTP and form filaments. Their high degree of conservation, ubiquitous expression and proven role in cytokinesis suggests septins are certain to be important players in regulating cell architecture and function. Septins alone can form regular filamentous polymers, since filament formation is likely to be central to their localisation and function.

(Field et al., 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

The Sep5 gene may be derived from the Sep2 gene by retroposition.

(Betran et al., 2002)

Nomenclature History

Source for database identify of

Source for identity of: Sep2 CG4173

(Gong, 1999.11)

Source for identity of: Septin2 Sep2

(FlyBase, 2009-)

Nomenclature comments

Changed from 'Sep2' to 'Septin2' to prevent the symbol being auto-converted into a date when used in spreadsheet programs (see PMID:15214961, PMID: 27552985).

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

38961

(Friedman et al., 2011)

CG4173

(Hosono et al., 2015, Li et al., 2010, Zhang et al., 2010, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Hughes et al., 2008, Goldstein and Gunawardena, 2000)

DSep2

(Mavrakis et al., 2014)

Sep2

(Stjepić et al., 2024, Frappaolo et al., 2022, Jia et al., 2022, Shuman and Momany, 2021, Carim et al., 2020, López-Gay et al., 2020, Akhmetova et al., 2018, Loyer and Januschke, 2018, Deb and Hasan, 2016, Deb et al., 2016, Akhmetova et al., 2015, Menon and Gaestel, 2015, Sechi et al., 2014, Fedoseeva and Tchurikov, 2013, Kwon et al., 2013, Kwon et al., 2013, O'Neill and Clark, 2013, O'Neill and Clark, 2013, Su et al., 2013, Giansanti and Fuller, 2012, Giansanti et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ruggiero et al., 2012, Neumüller et al., 2011, Bergner et al., 2010, Goldbach et al., 2010, Huijbregts et al., 2009, D'Avino et al., 2008, Fisher et al., 2008, Silverman-Gavrila et al., 2008, Buszczak et al., 2007, Gilliland et al., 2007, Langille and Clark, 2007, Langille and Clark, 2007, Pan et al., 2007, Field et al., 1996)

Septin2

(Price et al., 2023)

dSEPT2

(Deb and Hasan, 2016)

sep2

(Founounou et al., 2013, Mazumdar and Mazumdar, 2002, Hales et al., 2000, Al-Awar, 1995.6.12, Al-Awar et al., 1995, Miller and Kiehart, 1995, Fares et al., 1994)

Name Synonyms

Septin 2

Septin-2

(Taniguchi et al., 2014, Liu and Lehmann, 2008, Bakal et al., 2007, Al-Awar et al., 1995)

Septin2

(Loyer and Januschke, 2018, Morais-de-Sá and Sunkel, 2013)

septin

(Sisson et al., 2000, Guild et al., 1999, Field et al., 1997, Oegema et al., 1997)

septin 2

(Deng and Lin, 2001)

septin-2

(Ugrankar et al., 2015, Lesch and Page, 2012, Echard et al., 2004)

septin2

(Founounou et al., 2013)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42438

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P54359

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P54359

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KGJ1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P54359

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0014029

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42438/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014029

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014029

FlyMine - An integrated database for Drosophila genomics

FBgn0014029

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4173

MARRVEL_MODEL - MARRVEL (model organism gene)

42438

PDB - An information portal to biological macromolecular structures

8DKT

Linkouts

BioGRID - A database of protein and genetic interactions.

67416

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0014029

DroID - A comprehensive database of gene and protein interactions.

FBgn0014029

DRSC - Results frm RNAi screens

FBgn0014029

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sep2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014029

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0014029

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4173

Flygut - An atlas of the Drosophila adult midgut

FBgn0014029

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008188

MIST (protein-protein) - An integrated Molecular Interaction Database

42438

References (137)

The following external sites may use different assemblies or annotations than FlyBase.

-0.21

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