Ofut1, neurotic, nti, O-fucosyl transferase, O-fut
modifies Notch by attaching fucose within EGF domains - positively required for Notch signaling, essential for the physical interaction of Notch with its ligand Delta and for the ability of Fringe to modulate this interaction
Please see the JBrowse view of Dmel\O-fut1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Interacts with N (via its EGF domains); the interaction is required for the endocyctic transport of N.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\O-fut1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Transcript is detected uniformly throughout early embryos and gradually disappears by stage 11.
Transcript is highly expressed in the lymph gland and germ cells of the gonad in post Stage 12 embryos. The transcript is uniform in some larval tissues such as the wing, haltere, leg and antennal discs but shows an increased level of expression posterior to the morphogenetic furrow in eye discs and a complex expression pattern in the larval central nervous system.
JBrowse - Visual display of RNA-Seq signals
View Dmel\O-fut1 in JBrowse2-69
2-74.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
1 allele of O-fut1 recovered in a P-insertion screen.
Embryos derived from homozygous germline clones show a strong neurogenic phenotype. Zygotic mutant embryos have a normal nervous system. Mutant clones in the wing result in loss of wing margin and vein thickening.
Source for merge of: O-fut1 l(2)SH2260
Source for identity of: O-fut1 CG12366