GADD34, dPPP1R15
Please see the JBrowse view of Dmel\PPP1R15 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
5' UTR contains an ORF as described in Malzer et al (FBrf0221464); potential peptide 49 aa in length; initial methionine is conserved; an intact uORF represses Gadd34 translation except under conditions of ER stress (tunicamycin).
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PPP1R15 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
PPP1R15 transcripts are abundant in the yolk sac at stage 5 suggesting a maternal contribution. During gastrulation, they are found in invaginating endoderm and the surrounding ectoderm. Strong signal is later observed in epidermis, brain, Malpighian tubule, and the primordia of the midgut and hindgut. At later stages of embryogenesis, signal is mainly observed in the CNS.
JBrowse - Visual display of RNA-Seq signals
View Dmel\PPP1R15 in JBrowse2-105
2-109.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
FlyBase Curator comment: Queried author Kampinga who said "The drosophila GADD34 we mention in our JBC paper is CG3825".
Source for identity of: Gadd34 CG3825
Source for identity of: PPP1R15 Gadd34
Named 'Gadd34' after its human ortholog.