FlyBase Gene Report: Dmel\MEP-1

General Information

Symbol

Dmel\MEP-1

Species

D. melanogaster

Name

MEP-1

Annotation Symbol

CG1244

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035357

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

MEP-1 (MEP-1) encodes a zinc finger protein that associates with the ATP-dependent nucleosome remodeler encoded by Mi-2. It cooperates with the product of Mi-2 in the repression of cell type-specific genes. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

62E8-62E8

Sequence location

3L:2,631,715..2,641,984 [+]

Recombination map

3-3

RefSeq locus

NT_037436 REGION:2631715..2641984

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables ATPase activator activity

inferred from direct assay

(Kunert et al., 2009)

enables chromatin binding

inferred from direct assay

(Kunert et al., 2009)

enables protein binding

inferred from physical interaction with FLYBASE:Mi-2; FB:FBgn0262519

(Kunert et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

enables sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of transcription by RNA polymerase II

inferred from direct assay

(Kunert et al., 2009)

involved_in piRNA-mediated retrotransposon silencing by heterochromatin formation

inferred from mutant phenotype

(Mugat et al., 2020)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Kunert et al., 2009)

part_of NuRD complex

inferred from physical interaction with FLYBASE:Mi-2; FB:FBgn0262519

(Reddy et al., 2010)

located_in polytene chromosome

inferred from direct assay

(Reddy et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NUCLEOSOME REMODELING DEACETYLASE COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NUCLEOSOME REMODELING DEACETYLASE COMPLEX -: The nucleosome remodelling and deacetylase (NuRD) complex couples chromatin remodelling and histone deacetylation to mediate transcriptional repression. (Adapted from FBrf0228973 and FBrf0228920).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\MEP-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0E8J0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2008)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

MEP-1-RA

FBtr0072932

NM_139476

4966

1152

MEP-1-RB

FBtr0072933

NM_167958

4956

1152

MEP-1-RC

FBtr0072931

NM_167959

5111

1152

MEP-1-RD

FBtr0072934

NM_167960

4732

1152

MEP-1-RE

FBtr0072936

NM_167961

4555

1152

MEP-1-RF

FBtr0072935

NM_167962

4545

1152

MEP-1-RG

FBtr0290340

NM_001144403

5171

1152

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

MEP-1-PA

FBpp0072809

124.1

1152

4.65

FBpp0072810

124.1

1152

4.65

FBpp0072808

124.1

1152

4.65

FBpp0072811

124.1

1152

4.65

FBpp0072813

124.1

1152

4.65

FBpp0072812

124.1

1152

4.65

FBpp0288779

124.1

1152

4.65

Q0E8J0

NP_001137875

ACL83231

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1152 aa isoforms: MEP-1-PA, MEP-1-PB, MEP-1-PC, MEP-1-PD, MEP-1-PE, MEP-1-PF, MEP-1-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MEP-1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunodetection (other than il)

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

wing disc

(Kunert et al., 2009)

embryonic/larval brain

(Kunert et al., 2009)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4

primordial germ cell

(Kunert et al., 2009)

organism

(Kunert et al., 2009)

oogenesis

nurse cell

(Kunert et al., 2009)

oocyte

• germinal vesicle

(Kunert et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 12

organism

(Kunert et al., 2009)

Additional Descriptive Data

MEP-1 protein is detected in the first 9 hours of embryonic development and then levels drop off sharply.

(Kunert et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Kunert et al., 2009)

part_of NuRD complex

inferred from physical interaction with FLYBASE:Mi-2; FB:FBgn0262519

(Reddy et al., 2010)

located_in polytene chromosome

inferred from direct assay

(Reddy et al., 2010)

Expression Deduced from Reporters

Reporter: PBac{768.FSVS-0}MEP-1^CPTI003583

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\MEP-1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\MEP-1

View exonic expression by tissue for Dmel\MEP-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38327/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035357

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035357

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035357

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1244

Flygut - An atlas of the Drosophila adult midgut

FBgn0035357

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of MEP-1

Transgenic constructs containing regulatory region of MEP-1

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

MEP-1^HMS00540

lethal | recessive

MEP-1^GTD74-56

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

MEP-1^GD7728

viable, with Scer\GAL4^Mef2.PR

MEP-1^GD7728

Other Phenotypes

Allele

abnormal size | adult stage, with Scer\GAL4^ey.PH

MEP-1^HMS00540

visible | adult stage, with Scer\GAL4^Act5C.PI

MEP-1^GL00319

visible | adult stage, with Scer\GAL4^ey.PH

MEP-1^HMS00540

visible | adult stage, with Scer\GAL4^GMR.PF

visible | adult stage, with Scer\GAL4^nub.PK

MEP-1^GL00319

visible | male limited, with Scer\GAL4^Bx-MS1096

MEP-1^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

eye, with Scer\GAL4^ey.PH

MEP-1^HMS00540

eye, with Scer\GAL4^GMR.PF

posterior crossvein, with Scer\GAL4^nub.PK

MEP-1^HMS00540

wing | male limited, with Scer\GAL4^Bx-MS1096

MEP-1^{UAS.ORF.GW.Tag:HA}

wing blade, with Scer\GAL4^Act5C.PI

MEP-1^GL00319

wing blade, with Scer\GAL4^en.PU

MEP-1^HMS00540

wing blade, with Scer\GAL4^nub.PK

MEP-1^HMS00540

wing vein, with Scer\GAL4^en.PU

MEP-1^HMS00540

wing vein, with Scer\GAL4^nub.PK

MEP-1^GL00319

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\PLAGL2

1 of 14

Yes

Hsap\ZBTB21

1 of 14

Yes

Hsap\ZFY

1 of 14

Yes

Hsap\ZNF316

1 of 14

Yes

Hsap\ZNF787

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Zfp316

1 of 14

Yes

Rnor\Zfp423

1 of 14

Yes

Rnor\Zfp451

1 of 14

Yes

Rnor\Zfp787

1 of 14

Yes

Mus musculus (laboratory mouse) (11)

Mmus\Plagl2

1 of 14

Yes

Mmus\Zbtb21

1 of 14

Yes

Mmus\Zbtb48

1 of 14

Yes

Mmus\Zfa-ps

1 of 14

Yes

Mmus\Zfp316

1 of 14

Yes

Mmus\Zfp423

1 of 14

Yes

Mmus\Zfp438

1 of 14

Yes

Mmus\Zfp532

1 of 14

Yes

Mmus\Zfp592

1 of 14

Yes

Mmus\Zfp687

1 of 14

Yes

Mmus\Zfp787

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\zbtb21

1 of 13

Yes

Xtro\znf423

1 of 13

Yes

Xtro\znf451

1 of 13

Yes

Danio rerio (Zebrafish) (3)

Drer\si:ch211-202h22.10

1 of 14

Yes

Drer\si:dkey-14k9.3

1 of 14

Yes

Drer\zbtb12.1

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\mep-1

10 of 14

Yes

Cele\C04F5.9

1 of 14

Yes

Cele\F56D1.1

1 of 14

Yes

Cele\ham-2

1 of 14

Cele\M03D4.4

1 of 14

Yes

Cele\pzf-1

1 of 14

Cele\R10E4.11

1 of 14

Yes

Cele\ztf-1

1 of 14

Yes

Cele\ztf-26

1 of 14

Yes

Cele\ztf-28

1 of 14

Cele\ztf-29

1 of 14

Cele\ztf-30

1 of 14

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP006601

6 of 12

Yes

Agam\AgaP_AGAP004285

1 of 12

Agam\AgaP_AGAP006129

1 of 12

Yes

Agam\AgaP_AGAP006544

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007804

1 of 12

Yes

Agam\AgaP_AGAP008134

1 of 12

Yes

Agam\AgaP_AGAP009069

1 of 12

Yes

Agam\AgaP_AGAP012027

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:MEP-1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

1 of 13

1 of 13

1 of 13

1 of 13

row

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

MEP-1

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Reddy et al., 2010)

MEP-1 - CDK2AP1

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Reddy et al., 2010)

MEP-1 - CG3726

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

MEP-1 - Caf1-55

anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot, molecular sieving, molecular weight estimation by staining

(Mugat et al., 2020, Reddy et al., 2010)

MEP-1 - CtBP

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Reddy et al., 2010)

MEP-1 - HDAC1

anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot, molecular sieving, molecular weight estimation by staining

(Mugat et al., 2020, Reddy et al., 2010)

MEP-1 - Lint-O

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Reddy et al., 2010)

MEP-1 - MBD-like

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Reddy et al., 2010)

MEP-1 - MTA1-like

anti bait coimmunoprecipitation, Identification by mass spectrometry, molecular sieving, molecular weight estimation by staining, western blot

(Mugat et al., 2020, Reddy et al., 2010)

MEP-1 - Mi-2

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, ion exchange chromatography, affinity chromatography technology, molecular weight estimation by staining, peptide massfingerprinting, pull down, autoradiography, molecular sieving

(Mugat et al., 2020, Cugusi et al., 2015, Reddy et al., 2010, Kunert et al., 2009, Stielow et al., 2008)

MEP-1 - Pten

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

MEP-1 - Sfmbt

pull down, autoradiography

(Stielow et al., 2008)

MEP-1 - Su(var)2-10

luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Mugat et al., 2020)

MEP-1 - Sumo

pull down, autoradiography

(Stielow et al., 2008)

MEP-1 - Top2

anti bait coimmunoprecipitation, western blot

(Cugusi et al., 2015)

MEP-1 - Trl

two hybrid, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Lomaev et al., 2017)

MEP-1 - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

MEP-1 - arx

anti bait coimmunoprecipitation, western blot, pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping

(Mugat et al., 2020)

MEP-1 - egg

anti bait coimmunoprecipitation, western blot

(Mugat et al., 2020)

MEP-1 - gcm

two hybrid

(Jacques et al., 2009)

MEP-1 - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

MEP-1 - mle

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation

(Cugusi et al., 2015)

MEP-1 - nej

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Reddy et al., 2010)

MEP-1 - piwi

anti bait coimmunoprecipitation, western blot

(Mugat et al., 2020)

MEP-1 - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

MEP-1 - simj

anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot

(Cugusi et al., 2015, Reddy et al., 2010)

MEP-1 - ttk

two hybrid, pull down, autoradiography, anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot

(Khalisova et al., 2021, Reddy et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63832

DroID - A comprehensive database of gene and protein interactions.

FBgn0035357

MIST (protein-protein) - An integrated Molecular Interaction Database

38327

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-3

Cytogenetic map

62E8-62E8

Sequence location

3L:2,631,715..2,641,984 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62E8-62E8

Limits computationally determined from genome sequence between P{PZ}Spn⁰⁶⁹¹¹ and P{PZ}l(3)06803⁰⁶⁸⁰³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

62F1-62F2

(determined by in situ hybridisation)

(Lukacsovich et al., 2001)

Experimentally Determined Recombination Data

Location

3-3

(FlyBase, 2016)

3-5.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (182)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035357

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035357

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Reddy et al., 2010, Kunert et al., 2009)

monoclonal

(Kunert et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

DNA-protein interactions: genome-wide binding profile assayed for MEP-1 protein in S2 cells; GEO accession number GSE32404.

(Moshkin et al., 2012)

dsRNA has been made from templates generated with primers directed against this gene. RNAi of CG1244 disrupts the dendritic routing patterns of the ddaD and ddaE neurons, resulting in aberrantly oriented primary dendrites. The overall arborization of these neurons is reduced. Additionally, RNAi causes defects in dendrite morphogenesis.

(Parrish et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG1244 anon- EST:Liang-1.37

(FlyBase, 1996-)

Source for merge of: CG1244 anon-WO0118547.584

(FlyBase, 1996-)

Additional comments

One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG42245 (FBgn0250911), CG1244 (FBgn0035357).

(FlyBase Genome Annotators, 2008)

Source for merge of CG1244 anon- EST:Liang-1.37 was sequence comparison ( date:030722 ).

(FlyBase, 1996-)

Source for merge of CG1244 anon-WO0118547.584 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: MEP-1 CG1244

(Stielow et al., 2008)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG1244

(Lomaev et al., 2017, Hosono et al., 2015, Ashwal-Fluss et al., 2014, Ni et al., 2011.7.19, Gan et al., 2010, Ni et al., 2010.12.1, Reddy et al., 2010, Jacques et al., 2009, Perkins et al., 2009, FlyBase Genome Annotators, 2008, Stielow et al., 2008, Parrish et al., 2006, Stanyon et al., 2004)

MEP1

(Moshkin et al., 2012, Reddy et al., 2010)

Mep-1

(Godneeva et al., 2023, Chetverina et al., 2021, Khalisova et al., 2021)

Q0E8J0_DROME

(Fukuyama et al., 2012)

anon-EST:Liang-1.37

anon-WO0118547.584

clone 1.37

(Liang and Biggin, 1998)

dMEP-1

(Kunert et al., 2009)

Name Synonyms

CG1244

(FlyBase Genome Annotators, 2008)

MEP-1

Secondary FlyBase IDs

FBgn0025995
FBgn0061858

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 58 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38327

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0E8J0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0E8J0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38327/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035357

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035357

FlyMine - An integrated database for Drosophila genomics

FBgn0035357

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1244

MARRVEL_MODEL - MARRVEL (model organism gene)

38327

Linkouts

BioGRID - A database of protein and genetic interactions.

63832

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035357

DroID - A comprehensive database of gene and protein interactions.

FBgn0035357

DRSC - Results frm RNAi screens

FBgn0035357

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035357

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035357

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1244

Flygut - An atlas of the Drosophila adult midgut

FBgn0035357

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002395

MIST (protein-protein) - An integrated Molecular Interaction Database

38327

References (80)

The following external sites may use different assemblies or annotations than FlyBase.

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