Insertion of gypsy element.
lz1 adults have a severe mutant eye phenotype. Ectopic cell death is seen in third larval instar eye discs (this phenotype is variable).
Homozygotes show disruption of the ommatidial array and fusion of ommatidia across the posterior half of the eye. Black pock marks are visible on the surface of the eye. The retina and lamina are severely disorganised. The deeper optic lobes are normal. lz1/lz50e and lz1/lz77a7 females show disruption of the ommatidia and black pock marking confined to the anterior portion of the eye.
Mutants display locomotor activity rhythms with circadian periods, though with reduced penetrance (small sample size).
The antennal funiculus is reduced in size in hemizygous males. The large and small basiconic sensilla on the antennal funiculus are missing, and the number of trichoid sensilla on the antennal funiculus is reduced. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic sensilla on the antennal funiculus is increased compared to wild-type.
Mutants lack antennal basiconic sensilla, have a marked deficit in trichoid sensilla and small increase in coeloconic sensilla. Basiconic-like sensilla on the maxillary palps are only partially eliminated. In a 'jump assay' mutants do not jump in response to strong olfactory stimuli, undiluted organic chemicals. Flies are sluggish and tend to become motionless after short periods of time. Strong concentrations of chemicals elicit a strong response, flies start immediately to move, the walk response. Elimination of the maxillary palp sensilla by palp ablation does not change the response. Ethanol is capable of evoking a walk response at concentrations lower than 10%. EAG responses to alcohols (but not to esters) are markedly lower than wild type.
Eyes are narrowed and ovoid, and have irregular facets in some areas.
Homozygotes have rough eyes which are reduced in size. Red eye pigment is distributed over the entire eye. The tarsal claws are reduced. The spermathecae and pars ovariae are absent in homozygous females.
Eye narrower than wild type and ovoid. Irregular facets in some areas cause rough patches; areas of fused facets appear as smooth patches. Eye color appears normal but, in combination with st, slight reduction in red pigment detectable. Tarsal claws reduced. Developmental study by Waddington and Pilkington (1942) shows failure of middle cell layer of optic disk to penetrate between cells of outer layer; surface thus covered with primary pigment cells. female-sterile. Parovaria and spermathecae absent; some lz/+ females have abnormal parovaria (Anderson, 1945). Suppressed by su(f)6 (Schalet, 1970), su(Hw)2, e(we)1 and su(pr)3; enhanced by su(s)3 and su(wa) (Rutledge et al., 1988). Phenol oxidase activity increased from 17% to 71% normal (Snyder and Smith, 1976). RK1. glossy; tarsal structures reduced or absent; spermathecae absent; parovaria absent
lz1 has phenotype, enhanceable by mod(mdg4)ul
lz1/lz[+] is a suppressor of eye phenotype of HUAS.cMa, Scer\GAL4GMR.PU
The small-eye phenotype observed in animals expressing HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU is significantly suppressed in a lz1/+ mutant background.
Bridges, 12th Feb. 1916.
lz1 maps to the lozenge sublocus of lz.