FlyBase Allele Report: Dmel\lz[g]

General Information

Symbol

Dmel\lz^g

Species

D. melanogaster

Name

glossy

FlyBase ID

FBal0011822

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Batterham et al., 1996, Green and Green, 1956)

Progenitor genotype

Cytology

Description

Amino acid replacement: H771K. Also includes a single base deletion that causes a frame-shift.

(Jackson Behan et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

X:9,302,702..9,302,704 [+]

Inserted_sequence:

Comment:

There is an A to T substitution that leads to a H771L codon change. A single base deletion two bases downstream leads to a frameshift.

(Jackson Behan et al., 2005, Batterham et al., 1996, Green and Green, 1956)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Fuyama, 1995)

visible | recessive

(Goulding et al., 2000, Batterham et al., 1996, Green and Green, 1956)

Phenotype Manifest In

Detailed Description

Statement

Reference

The number of sensilla basiconica is reduced to 28% of wild-type in lz^g mutants.

(Goulding et al., 2000)

Homozygotes show general disruption of the ommatidial array and black pock marking that is more severe at the posterior rim of the eye. lz^g/lz^50e and lz^77a7/lz^g females show disruption of the ommatidia and black pock marking confined to the anterior portion of the eye.

(Batterham et al., 1996)

Females rarely accept courting males and exhibit an unusually high rate of spontaneous ovulation.

(Fuyama, 1995)

Displays locomotor activity rhythm with an approximately 24h period.

(Vosshall and Young, 1995)

The antennal funiculus is reduced in size in hemizygous males. The number of large and small basiconic sensilla on the antennal funiculus is greatly reduced, and the number of trichoid sensilla on the antennal funiculus is increased. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic and trichoid sensilla on the antennal funiculus is increased and the density of the small basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

(Stocker et al., 1993)

Homozygotes have rough eyes which are reduced in size. Red eye pigment is distributed over the entire eye. The tarsal claws are reduced. The spermathecae and pars ovariae are absent in homozygous females.

(Green and Green, 1956)

Females lack spermatheca and parovaria.

(Oliver, 1940)

Eyes smaller than wild type; surface glossy from fused facets; a few normal facets also present; color dark blood red, bright red in combination with st or v. Larval Malpighian tubes slightly lighter than normal (Brehme and Demerec, 1942). Tarsal claws reduced. Spermathecae and parovaria absent from homozygous females, which have reduced fertility; lz^g/+ females tend to have abnormal parovaria (Anderson, 1945). RK1. glossy; tarsal structures reduced or absent; spermathecae absent; parovaria absent more or less female fertile lz^g/lz^s provided probably the first recorded case of intra-allelic recombination (Oliver, 1940a; Oliver, 1940b).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

lz^g has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Other

Statement

Reference

Df(2L)M36F-S6/lz^g, rn^tod has basiconic sensillum phenotype

(Li et al., 2013)

Df(2L)M36F-S6/lz^g, rn^tod has trichoid sensillum phenotype

(Li et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

As in lz^g/Y mutants alone,the basiconic sensilla in rn^tod/rn^tot, lz^g/Df(2L)M36F-S6 double mutants have been converted to trichoid sensilla. The at1 sensilla have been converted to at4 in both trichoid zones.

(Li et al., 2013)

A further 70% reduction in the number of sensilla basiconica in lz^g mutants is seen if one copy of the chromosomal region containing amos is also removed. The number of sensilla trichodea is unaffected.

(Goulding et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

lz^77a7

(Batterham et al., 1996)

lz^38.71

(Batterham et al., 1996)

Partially complements

lz³⁷