FlyBase Allele Report: Dmel\N[264-40]

General Information

Symbol

Dmel\N^264-40

Species

D. melanogaster

Name

FlyBase ID

FBal0012749

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

?{}N^264-40

Carried in Construct

Also Known As

N^264.40

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cadigan and Nusse, 1996, Gorman and Girton, 1992)

loss of function allele

(Lehmann et al., 1983)

Mutagen

X ray

Progenitor genotype

Associated Insertion(s)

?{}N^264-40

Cytology

Polytene chromosomes apparently normal (Hoover).

Polytene chromosomes normal.

(Lefevre and Peterson, 1972)

Description

Insertion at the proximal edge of two clustered microexons, exons 3 and 4.

(Lyman and Young, 1993)

Insertion of a copia-like element at coordinate -6kb (coordinates according to FBrf0045027 and FBrf0039003).

(Kelley et al., 1987)

Lesion associated with a 0.4 kb insertion between -6.2 and -5.6 kb on the physical map of Notch (Kidd, Lockett and Young, 1983).

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

central nervous system

(Jack and DeLotto, 1992)

embryonic/larval pericardial cell | germline clone

(Park et al., 1998)

embryonic epidermis

(Lehmann et al., 1983)

wing

(Jack and DeLotto, 1992, Foster, 1973)

wing sensillum

(Palka et al., 1990)

Detailed Description

Statement

Reference

eve-expressing pericardial cells fail to form in embryos derived from homozygous female germline clones.

(Park et al., 1998)

Homozygotes exhibit hypertrophy of the nervous system and a gap in the tip of the wing margin.

(Jack and DeLotto, 1992)

Heterozygotes have slightly elevated numbers of sensilla on the wing.

(Palka et al., 1990)

Extreme embryonic neurogenic phenotype.

(Lehmann et al., 1983)

Male flies carrying Dp(1;2)51bV76e show wing-notching and lateral incisions, leg defects and tarsal reductions, missing or multiple bristles, missing or fused ocelli and variegated or roughened eyes, at varying frequencies.

(Poulson and Lefevre, 1982)

Lethal in combination with N^l1N-ts1 or N^Ax-tsl at 29^oC. Homozygous lethal at 29^oC.

(Shellenbarger and Mohler, 1975)

Heterozygotes have a nicked wing phenotype. N^Ax-16/N^264-40 females show temperature sensitive lethality. The temperature sensitive period for lethality is during the second larval instar stage.

(Foster, 1973)

Lethality is not covered by Dp(1;3)N^264-58.

(Demerec, 1940)

Typical Notch. Male embryos show developmental abnormalities like those of Df(1)N-8 (Poulson, 1939). Lethal with N^nd-3.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

N^264-40/N[+] is an enhancer of visible | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

N^264-40 is an enhancer of visible phenotype of E(spl)mα-BFM^UAS.cAa, Scer\GAL4^455.2

(Apidianakis et al., 1999)

Other

Statement

Reference

E(spl)m4-BFM^UAS.cAa, N^264-40, Scer\GAL4^455.2 has visible phenotype

(Apidianakis et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

N^264-40/N[+] is an enhancer of notal microchaeta | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

N^264-40/N[+] is an enhancer of tormogen cell | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

N^264-40/N[+] is an enhancer of trichogen cell | adult stage | ectopic phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

N^264-40 is an enhancer of scutellar bristle phenotype of E(spl)mα-BFM^UAS.cAa, Scer\GAL4^455.2

(Apidianakis et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of arm¹ is unable to enhance the wing notching seen in N^264-40 heterozygotes.

One copy of Klp64D^k1 is unable to enhance the wing notching seen in N^264-40 heterozygotes.

(Vuong et al., 2014)

N^264-40 enhances the supernumerary scutellar bristle phenotype seen in flies with mα^Scer\UAS.cAa driven by Scer\GAL4^455.2.

(Apidianakis et al., 1999)

All structures that have mutant phenotypes in dx^D and N^264-40 heterozygotes show synergistic interactions in dx^D/N^264-40 transheterozygotes.

(Gorman and Girton, 1992)

Double mutant combinations with ct^46l and ct^53d exhibit gaps in the entire wing margin.

(Jack and DeLotto, 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

2212

w^a N^264-40 rb¹/C(1)DX, y¹ w¹ f¹; Dp(1;2)72c21/+

Notes on Origin

Discoverer

Demerec, April 1937.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

N^-40

(Foster, 1973)

N^246-40

(Park et al., 1998)

N^264-40

(Vuong et al., 2014, Endo et al., 2011)

N^264.40

(Apidianakis et al., 1999, Cadigan and Nusse, 1996)

N⁴⁰

(Poulson and Lefevre, 1982)

Name Synonyms

Secondary FlyBase IDs

References (27)

Report Sections

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