FlyBase Allele Report: Dmel\Drp1[T26]

General Information

Symbol

Dmel\Drp1^T26

Species

D. melanogaster

Name

FlyBase ID

FBal0039507

Feature type

allele

Associated gene

Dmel\Drp1

Associated Insertion(s)

Carried in Construct

Also Known As

l(2)22Fd^T26

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Littleton and Bellen, 1994)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Littleton and Bellen, 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

Drp1^T26/+ mutants are fully viable.

(Poole et al., 2008)

No hemizygous pupae are recovered.

(Littleton and Bellen, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Drp1^T26 is an enhancer of abnormal neuroanatomy phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Drp1^T26 is an enhancer of abnormal cell death phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Suppressor of

Statement

Reference

Drp1[+]/Drp1^T26 is a suppressor of visible phenotype of Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Other

Statement

Reference

Drp1[+]/Drp1^T26, park²⁵ has lethal phenotype

(Poole et al., 2008)

Drp1[+]/Drp1^T26, Pink1^B9 has partially lethal - majority die phenotype

(Poole et al., 2008)

Drp1[+]/Drp1^T26, Pink1^B9 has abnormal developmental rate phenotype

(Poole et al., 2008)

Drp1[+]/Drp1^T26, Pink1^B9 has short lived phenotype

(Poole et al., 2008)

Drp1[+]/Drp1^T26, Pink1^B9 has decreased body size phenotype

(Poole et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Drp1^T26 is an enhancer of adult brain phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Drp1^T26 is an enhancer of mitochondrion phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Suppressor of

Statement

Reference

Drp1[+]/Drp1^T26 is a suppressor of eye phenotype of Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Drp1^T26/+ in combination with park²⁵/park²⁵ mutants results in lethality. Viability of flies Drp1^T26/+ is unaffected in a park²⁵/+ background.

Drp1^T26/+ in combination with Pink1^B9 hemizygous mutations results in almost complete lethality. The few surviving adults are developmentally delayed and are substantially smaller and short lived than single Pink1^B9 hemizygous mutants. Viability of Drp1^T26/+ flies is unaffected in a heterozygous Pink1^B9/+ background.

The rough eye phenotype of flies expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed in the presence of Drp1^T26/+ mutation.

(Poole et al., 2008)

Xenogenetic Interactions

Statement

Reference

Drp1^T26 enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU. Increased levels of neurotoxicity are also seen.

(Duboff et al., 2012)

Complementation and Rescue Data

Fails to complement

Drp1¹

(Ly, 2005.3.2)

Drp1²

(Ly, 2005.3.2)

Drp1^KG03815

(Verstreken et al., 2005)

Comments

Images (0)

Mutant