FlyBase Allele Report: Dmel\aop[UAS.cRa]

General Information

Symbol

Dmel\aop^UAS.cRa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Rebay

FlyBase ID

FBal0042855

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

Carried in Construct

P{UAS-aop.WT}

Also Known As

UAS-yan, UAS-yan^WT, UAS-aop, UAS-aop^WT, UAS-aop.WT

Key Links

Transgenic product class

cDNA

(Rebay and Rubin, 1995)

wild_type

(Rebay and Rubin, 1995)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Rebay and Rubin, 1995)

wild_type

(Rebay and Rubin, 1995)

Mutagen

in vitro construct

(O'Keefe et al., 1997, Rebay and Rubin, 1995)

Progenitor genotype

Carried in construct

P{UAS-aop.WT}

Cytology

Description

UAS regulatory sequences drive expression of a wild-type aop cDNA.

(Rebay and Rubin, 1995)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

aop

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407, Scer\GAL80^ase.PZ

(Zhu et al., 2011)

abnormal size, with Scer\GAL4^ey.PU

(Salzer et al., 2010)

visible, with Scer\GAL4^ey.PB

(Kumar and Moses, 2001)

visible, with Scer\GAL4^ey.PU

(Salzer et al., 2010)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PB

(Kumar and Moses, 2001)

eye, with Scer\GAL4^ey.PU

(Salzer et al., 2010)

intermediate neuronal progenitor | ectopic | larval stage, with Scer\GAL4^insc-Mz1407, Scer\GAL80^ase.PZ

(Zhu et al., 2011)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Charroux et al., 2006)

ommatidium, with Scer\GAL4^GMR.PF

(Charroux et al., 2006)

Detailed Description

Statement

Reference

Expression of aop^Scer\UAS.cRa in type II neuroblasts using Scer\GAL4^insc-Mz1407 and Scer\GAL80^ase.PZ results in near total elimination of intermediate neural progenitor cells.

(Zhu et al., 2011)

Expression of aop^Scer\UAS.cRa driven by Scer\GAL4^ey.PU leads to a dramatic reduction in the size of the eye field.

(Salzer et al., 2010)

Expression of aop^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PF results in a normal-looking eye.

(Corl et al., 2009)

Flies expressing aop^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PF display a weak rough eye phenotype.

(Charroux et al., 2006)

Overexpression of aop^Scer\UAS.cRa in outer border cells, driven by Scer\GAL4^slbo.2.6, has no effect on border cell migration.

(Schober et al., 2005)

Embryos expressing aop^Scer\UAS.cRa under the control of Scer\GAL4^elav-C155 wild-type neuronal differentiation in the central nervous system.

(Tootle et al., 2003)

Expression of aop^Scer\UAS.cRa under the control of Scer\GAL4^ey.PB results in deletion of the eye.

(Kumar and Moses, 2001)

Embryos expressing aop^Scer\UAS.cRa under the control of Scer\GAL4^en-e16E have a normal denticle pattern.

(O'Keefe et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Scer\GAL4^GMR.PF, aop^UAS.cRa, hppy^RB.UAS has visible phenotype

(Corl et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, aop^UAS.cRa has interommatidial bristle phenotype, enhanceable by Gug^UAS.cCa, Scer\GAL4^GMR.PF

(Charroux et al., 2006)

Scer\GAL4^GMR.PF, aop^UAS.cRa has ommatidium phenotype, enhanceable by Gug^UAS.cCa, Scer\GAL4^GMR.PF

(Charroux et al., 2006)

Enhancer of

Statement

Reference

aop^UAS.cRa, Scer\GAL4^GMR.PF is an enhancer of interommatidial bristle phenotype of Gug^UAS.cCa, Scer\GAL4^GMR.PF

(Charroux et al., 2006)

aop^UAS.cRa, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Gug^UAS.cCa, Scer\GAL4^GMR.PF

(Charroux et al., 2006)

aop^UAS.cRa/Scer\GAL4^slbo.2.6 is an enhancer of border follicle cell phenotype of slbo⁰¹³¹⁰

(Schober et al., 2005)

Suppressor of

Statement

Reference

Gug^UAS.cCa/aop^UAS.cRa, Scer\GAL4^GMR.PF is a suppressor of wing vein | increased number phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Charroux et al., 2006)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/aop^UAS.cRa is a non-suppressor of wing vein | increased number phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Charroux et al., 2006)

Other

Statement

Reference

Scer\GAL4^GMR.PF, aop^UAS.cRa, hppy^RB.UAS has eye phenotype

(Corl et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of both aop^Scer\UAS.cRa and hppy^RB.Scer\UAS under the control of Scer\GAL4^GMR.PF results in a severe rough and "glossy" eye phenotype.

(Corl et al., 2009)

Flies that coexpress Gug^Scer\UAS.cCa and aop^Scer\UAS.cRa, under the control of Scer\GAL4^GMR.PF, show an enhanced rough eye phenotype, compared to flies expressing either single transgene. The third instar discs of flies expressing both transgenes are normal, suggesting that the effects observed in the adult eyes occur during the pupal stage.

Expression of either Gug^Scer\UAS.cCa or aop^Scer\UAS.cRa have very little effect on the extra wing vein material produced in flies that overexpress btl::Egfr^{Scer\UAS.T:λ\cI-DD} under the control of Scer\GAL4^GMR.PF. However, this wing vein phenotype is suppressed when Gug^Scer\UAS.cCa and aop^Scer\UAS.cRa are both expressed along with btl::Egfr^{Scer\UAS.T:λ\cI-DD} (all under the control of Scer\GAL4^GMR.PF).

(Charroux et al., 2006)

Expression of aop^Scer\UAS.cRa, driven by Scer\GAL4^slbo.2.6, weakly enhances border cell migration defects in slbo⁰¹³¹⁰ egg chambers.

(Schober et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5790

w^*; P{UAS-aop.WT}Ia/CyO

Kyoto

108426

w^*; P{UAS-aop.WT}Ia/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

aop^Scer\UAS.cRa

aop^UAS.cRa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Rebay

(Rebay and Rubin, 1995)

Secondary FlyBase IDs

References (24)

Report Sections

Open Close