FlyBase Allele Report: Dmel\eIF4A[k01501]

General Information

Symbol

Dmel\eIF4A^k01501

Species

D. melanogaster

Name

FlyBase ID

FBal0064594

Feature type

allele

Associated gene

Dmel\eIF4A

Associated Insertion(s)

P{lacW}eIF4A^k01501

Carried in Construct

Also Known As

eIF-4a^k01501, l(2)k01501

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}eIF4A^k01501

Cytology

Description

Insertion in the first intron.

(Li et al., 2005)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:5,982,008..5,982,008 [+]

(Jagut et al., 2013, Sofola et al., 2007, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

female germline stem cell | germline clone

(Shen et al., 2009)

Detailed Description

Statement

Reference

Approximately 60% of eIF-4a^k01501 germline stem cells detected 1 week after clone induction (ACI) are detected at 3 weeks ACI, whereas 76% of control germline stem cells detected 1 week ACI are detected at 3 weeks ACI.

(Shen et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

eIF4A^k01501 is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

eIF-4a[+]/eIF4A^k01501 is a non-enhancer of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

eIF4A^k01501 is a non-enhancer of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸

(Lee et al., 2001)

Suppressor of

Statement

Reference

eIF-4a[+]/eIF4A^k01501 is a suppressor of female sterile phenotype of bam^z3-2884/bam^Δ86

(Shen et al., 2009)

NOT Suppressor of

Statement

Reference

eIF4A^k01501 is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

eIF-4a[+]/eIF4A^k01501 is a non-suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

eIF4A^k01501 is a non-suppressor of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸

(Lee et al., 2001)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

eIF-4a[+]/eIF4A^k01501 is a non-enhancer of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Suppressor of

Statement

Reference

eIF-4a[+]/eIF4A^k01501 is a suppressor of eye phenotype of Dref^UAS.cSa

(Ida et al., 2009)

eIF-4a[+]/eIF4A^k01501 is a suppressor of ovariole phenotype of bam^z3-2884/bam^Δ86

(Shen et al., 2009)

eIF-4a[+]/eIF4A^k01501 is a suppressor of germarium phenotype of bam^z3-2884/bam^Δ86

(Shen et al., 2009)

eIF-4a[+]/eIF4A^k01501 is a suppressor of female germline stem cell | increased number phenotype of bam^z3-2884/bam^Δ86

(Shen et al., 2009)

NOT Suppressor of

Statement

Reference

eIF-4a[+]/eIF4A^k01501 is a non-suppressor of germarium phenotype of bam^Δ86

(Shen et al., 2009)

eIF-4a[+]/eIF4A^k01501 is a non-suppressor of ovariole phenotype of bam^Δ86

(Shen et al., 2009)

eIF-4a[+]/eIF4A^k01501 is a non-suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Most bam^z3-2884/bam^Δ86; eIF-4a^k01501/+ ovarioles contain 4-6 normal egg chambers, while the germaria contain fewer single germ cells compared to bam^z3-2884/bam^Δ86 ovarioles.

eIF-4a^k01501 fails to dominantly suppress the tumourous phenotype of bam^Δ86 ovarioles.

(Shen et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

eIF4A^YE9

(Li et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10506

y¹ w^67c23; P{lacW}eIF4A^k01501/CyO

Kyoto

111143

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}eIF4A^k01501 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: Kr-h1¹⁰⁶⁴².

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

eIF-4a^k01501

(Jagut et al., 2013, Ida et al., 2009, Sofola et al., 2007)

eIF4A^k01501

(Shen et al., 2009, Li et al., 2005)

l(2)k01501

(Lee et al., 2001, Spradling et al., 1999)

l(2)k01501^k01501

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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