FlyBase Allele Report: Dmel\eya[UAS.cBb]

General Information

Symbol

Dmel\eya^UAS.cBb

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct b of Bonini

FlyBase ID

FBal0089392

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

Carried in Construct

P{UAS-eya.B.II}

Also Known As

UAS-eya

Key Links

Transgenic product class

cDNA

(Bonini et al., 1998)

wild_type

(Bonini et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Bonini et al., 1998)

wild_type

(Bonini et al., 1998)

Mutagen

in vitro construct

(Bonini et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-eya.B.II}

Cytology

Description

A eya type II cDNA is expressed under the control of UAS regulatory sequences.

(Bonini et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

eya

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^dpp.blk1

(Bonini et al., 1998)

Phenotype Manifest In

antenna, with Scer\GAL4^dpp.blk1

(Bonini et al., 1998)

egg chamber & basement membrane | apical, with Scer\GAL4^upd1.PU

(Medioni and Noselli, 2005)

polar follicle cell, with Scer\GAL4^upd1.PU

(Medioni and Noselli, 2005)

Detailed Description

Statement

Reference

Expression of eya^Scer\UAS.cBb driven by Scer\GAL4^GMR.PU does not induce any discernible eye phenotypes.

(Wang et al., 2016)

Overexpression of eya^Scer\UAS.cBb using Scer\GAL4^upd blocks anterior polar cell differentiation in egg chambers. As a consequence, the apical cap, which is formed from basement membrane components, that covers anterior polar cells in wild-type egg chambers is not present.

(Medioni and Noselli, 2005)

Ectopic eyes containing pigmented ommatidia and bristles are produced, often in the antennal region, when eya^Scer\UAS.cBa is expressed under the control of Scer\GAL4^dpp.blk1.

(Bonini et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

eya^UAS.cBb, Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

eya^UAS.cBb, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of eya^Scer\UAS.cBb partially suppresses eye defects seen in flies with Lmx1a^Scer\UAS.cWa driven by Scer\GAL4^GMR.PU.

(Wang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^ap-md544/eya^UAS.cBb rescues Df(2L)eya¹⁰/eya^cli-IID

(Miguel-Aliaga et al., 2004)

Scer\GAL4^unspecified/eya^UAS.cBb rescues eya¹

(Zimmerman et al., 2000)

Scer\GAL4^unspecified/eya^UAS.cBb rescues eya²

(Zimmerman et al., 2000)

Scer\GAL4^unspecified/eya^UAS.cBb rescues eya⁴

(Zimmerman et al., 2000)

Comments

The defects in innervate of the dorsal neurohemal organs by the Tv neurons that are seen in eya^cli-IID/Df(2L)eya¹⁰ embryos are largely rescued by expression of eya^Scer\UAS.cBb under the control of Scer\GAL4^ap-md544.

(Miguel-Aliaga et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5675

w¹¹¹⁸; P{UAS-eya.B.II}14

Kyoto

108355

w¹¹¹⁸; P{UAS-eya.B.II}14

Notes on Origin