FB2024_03 , released June 25, 2024
Allele: Dmel\tinUAS.cYa
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General Information
Symbol
Dmel\tinUAS.cYa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Yin
FlyBase ID
FBal0090094
Feature type
allele
Associated gene
Dmel\tin
Associated Insertion(s)
Carried in Construct
P{UAS-tin.Y}
Also Known As
UAS-tin
Key Links
Transgenic product class
cDNA
(Yin and Frasch, 1998)
wild_type
(Yin and Frasch, 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Yin and Frasch, 1998)
wild_type
(Yin and Frasch, 1998)
Mutagen
in vitro construct
(Xu et al., 1998, Yin and Frasch, 1998)
Progenitor genotype
Carried in construct
P{UAS-tin.Y}
Cytology
Description

A tin cDNA is expressed under the control of UASt regulatory sequences.

(Yin and Frasch, 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
tin
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tinScer\UAS.cYa in the dorsal mesoderm in stage 11-12 embryos, driven by Scer\GAL4tin.cBa, does not induce the production of supernumerary cardioblasts.

      (Reim and Frasch, 2005)

      Ectopic expression of tinScer\UAS.cYa in the lateral domain of the cardiogenic mesoderm, driven by either Scer\GAL4Mef2.PR or Scer\GAL4twi.PG, causes a marked reduction of lymph-gland progenitors and pericardial cells in stage 16 embryos.

      (Mandal et al., 2004)

      When tinScer\UAS.cYa is expressed under the control of Scer\GAL4twi.PB the embryonic dorsal vessel is either distorted or does not form at all.

      (Kremser et al., 1999)

      Stage 11 embryos expressing tinScer\UAS.cYa under the control of both Scer\GAL4how-24B and Scer\GAL4twi.PG have enlarged clusters of pericardial cell progenitors; each cluster contains 6-10 eve-expressing cells (e-PCs) compared to 3-4 cells per cluster in wild-type embryos. The number of e-PCs decreases to a normal level during subsequent stages and the heart appears to be normal.

      (Yin and Frasch, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of tinScer\UAS.cYa, driven by Scer\GAL4tin.cBa, results in the rescue of few additional cardioblasts in a Df(3L)DocA background. Coexpression of pnrScer\UAS.cHa and tinScer\UAS.cYa, under the control of Scer\GAL4tin.cBa, induces the formation of more cardioblasts than expression of pnrScer\UAS.cHa alone. When Doc2Scer\UAS.cRa is coexpressed with only tinScer\UAS.cYa, or pnrScer\UAS.cHa and tinScer\UAS.cYa together, large numbers of extra cardioblasts are formed. Expression of all three transgenes results in double the amount of cardioblasts compared to wild type. Coexpression of Doc2Scer\UAS.cRa, tinScer\UAS.cYa, and pnrScer\UAS.cHa, under the control of Scer\GAL4twi.2PE, causes widespread ectopic cardioblast formation to a much greater extent than expression of Doc2Scer\UAS.cRa alone or in combination with tinScer\UAS.cYa plus pnrScer\UAS.cHa.

      (Reim and Frasch, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tinScer\UAS.cYa
      tinUAS.cYa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Yin
      (Yin and Frasch, 1998)
      Secondary FlyBase IDs
        References (14)