FlyBase Allele Report: Dmel\pAbp[EP310]

General Information

Symbol

Dmel\pAbp^EP310

Species

D. melanogaster

Name

FlyBase ID

FBal0117409

Feature type

allele

Associated gene

Dmel\pAbp

Associated Insertion(s)

P{EP}pAbp^EP310

Carried in Construct

Also Known As

EP310

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Sigrist et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}pAbp^EP310

Cytology

Description

Insertion into the first 3' non-coding exon.

(Blagden et al., 2009)

P{EP} insertion in the 3' untranslated region.

(Hekmat-Scafe et al., 2005)

P{EP} insertion into the first 3' non-coding exon.

(Sigrist et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:18,145,742..18,145,742 [-]

(Fingerhut et al., 2019, Kavi et al., 2015, Pertceva et al., 2010, Blagden et al., 2009, Cziko et al., 2009, Hekmat-Scafe et al., 2005, Reiff et al., 2002, Gene Disruption Project members, 2001-, Sigrist et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Blagden et al., 2009)

abnormal meiotic cell cycle (with pAbp^k10109)

(Blagden et al., 2009)

abnormal neuroanatomy (with Df(2R)Pcl7B)

(Sigrist et al., 2000)

abnormal neurophysiology (with Df(2R)Pcl7B)

(Sigrist et al., 2000)

male sterile

(Blagden et al., 2009)

male sterile (with pAbp^k10109)

(Blagden et al., 2009)

viable

(Pertceva et al., 2010)

Phenotype Manifest In

bouton (with Df(2R)Pcl7B)

(Sigrist et al., 2000)

larval multidendritic class IV neuron | somatic clone, with Scer\GAL4^Act.PU

(Cziko et al., 2009)

neuromuscular junction (with Df(2R)Pcl7B)

(Sigrist et al., 2000)

spindle & spermatocyte

(Blagden et al., 2009)

spindle & spermatocyte (with pAbp^k10109)

(Blagden et al., 2009)

Detailed Description

Statement

Reference

17% of homozygous and 18% of pAbp^EP310/pAbp^k10109 spermatocytes show defects in meiosis, with the most common phenotype being detachment of the meiotic spindles from astral microtubules.

(Blagden et al., 2009)

Over-expression of pAbp^EP310 reduces dendrite branching, and alters dendritic morphology in larval class IV sensory neurons (induced under the control of Scer\GAL4^Act.PU). Total dendrite length is significantly reduced in these neurons.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a pAbp^EP310/+ background.

(Cziko et al., 2009)

The density of T-bars in the boutons of pAbp^EP310/Df(2R)Pcl7B mutants is the same as wild type.

(Reiff et al., 2002)

The mean amplitude of miniature postsynaptic currents (mEJCs) at the neuromuscular junction is indistinguishable from wild type in pAbp^EP310/Df(2R)Pcl7B flies. Evoked postsynaptic currents (eEJCs) are significantly larger than in wild-type. The number of junctional boutons per neuromuscular junction is increased compared to wild type.

(Sigrist et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

pAbp^EP310 has abnormal meiotic cell cycle phenotype, enhanceable by larp^mtr-null/larp[+]

(Blagden et al., 2009)

pAbp^EP310 has abnormal meiotic cell cycle phenotype, enhanceable by larp^S003108/larp[+]

(Blagden et al., 2009)

Enhancer of

Statement

Reference

pAbp[+]/pAbp^EP310 is an enhancer of abnormal meiotic cell cycle phenotype of larp^S003108

(Blagden et al., 2009)

pAbp[+]/pAbp^EP310 is an enhancer of visible phenotype of Df(1)os¹

(Mukherjee et al., 2006)

NOT Enhancer of

Statement

Reference

pAbp[+]/pAbp^EP310 is a non-enhancer of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Suppressor of

Statement

Reference

Scer\GAL4^elav.PLu/pAbp^EP310 is a suppressor of bang sensitive phenotype of eas²

(Hekmat-Scafe et al., 2005)

NOT Suppressor of

Statement

Reference

pAbp[+]/pAbp^EP310 is a non-suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Other

Statement

Reference

larp^mtr-null/larp[+], pAbp^EP310 has abnormal meiotic cell cycle | dominant phenotype

(Blagden et al., 2009)

larp^S003108/larp[+], pAbp^EP310 has abnormal meiotic cell cycle | dominant phenotype

(Blagden et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

pAbp^EP310 has spermatocyte phenotype, enhanceable by larp^mtr-null/larp[+]

(Blagden et al., 2009)

pAbp^EP310 has spermatocyte phenotype, enhanceable by larp^S003108/larp[+]

(Blagden et al., 2009)

Enhancer of

Statement

Reference

pAbp[+]/pAbp^EP310 is an enhancer of spermatocyte phenotype of larp^S003108

(Blagden et al., 2009)

pAbp[+]/pAbp^EP310 is an enhancer of eye phenotype of Df(1)os¹

(Mukherjee et al., 2006)

NOT Enhancer of

Statement

Reference

pAbp[+]/pAbp^EP310 is a non-enhancer of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Suppressor of

Statement

Reference

pAbp[+]/pAbp^EP310 is a suppressor of eye phenotype of Fmr1^sev.PW

(Cziko et al., 2009)

NOT Suppressor of

Statement

Reference

pAbp[+]/pAbp^EP310 is a non-suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Other

Statement

Reference

larp^mtr-null/larp[+], pAbp^EP310 has spermatocyte phenotype

(Blagden et al., 2009)

larp^S003108/larp[+], pAbp^EP310 has spermatocyte phenotype

(Blagden et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

23% of pAbp^EP310/+ ; larp^mtr-null/+ double heterozygous spermatocytes show defects in meiosis.

16% of pAbp^EP310/+ ; larp^S003108/+ double heterozygous spermatocytes show defects in meiosis.

The frequency of homozygous pAbp^EP310 spermatocytes that show defects in meiosis (17%) is increased by larp^mtr-null/+ (to 31.4%) or larp^S003108/+ (to 29.3%).

(Blagden et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17261

w¹¹¹⁸; P{EP}pAbp^EP310

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP310

(Mukherjee et al., 2006, Sigrist et al., 2000)

pAbp^EP0310

pAbp^EP310

(Singh et al., 2022, Pertceva et al., 2010, Blagden et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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