FlyBase Allele Report: Dmel\dome[ΔTMCYT.UAS]

General Information

Symbol

Dmel\dome^ΔTMCYT.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0126405

Feature type

allele

Associated gene

Dmel\dome

Associated Insertion(s)

Carried in Construct

P{UAS-dome.ΔTMCYT}

Also Known As

UAS-domeDN, UAS-Dome^DN

Key Links

Transgenic product class

inframe_deletion

(Brown et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Brown et al., 2001)

Mutagen

in vitro construct

(Castelli-Gair Hombria, 2001.9.19)

Progenitor genotype

Carried in construct

P{UAS-dome.ΔTMCYT}

Cytology

Description

UAS regulatory sequences drive expression of a truncated form of dome which lacks the transmembrane and intracellular domains.

(Brown et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dome

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic abdominal segment 4, with Scer\GAL4^{VP16.mat.αTub67C}

(Brown et al., 2001)

embryonic abdominal segment 5, with Scer\GAL4^{VP16.mat.αTub67C}

(Brown et al., 2001)

embryonic segment, with Scer\GAL4^{VP16.mat.αTub67C}

(Brown et al., 2001)

midgut, with Scer\GAL4^how-24B, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

midgut, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

Detailed Description

Statement

Reference

Expression of dome^{ΔTMCYT.Scer\UAS} under the control of Scer\GAL4^esg-NP5130 results in decreased intestinal stem cells (ISC) proliferation in response to Erwinia carotovora carotovora 15 (Ecc15) infection compared with wild-type.

Expression of dome^{ΔTMCYT.Scer\UAS} in visceral muscles under the control of Scer\GAL4^how-24B results in decreased intestinal stem cells (ISC) proliferation in response to Erwinia carotovora carotovora 15 (Ecc15) infection compared with wild-type.

(Buchon et al., 2010)

Scer\GAL4^{Myo31DF-NP0001}-mediated expression of dome^{ΔTMCYT.Scer\UAS} results in significantly increased survival following infection with S. marcescens compared to controls.

(Cronin et al., 2009)

Expression of dome^{ΔTMCYT.Scer\UAS} in border cells, driven by Scer\GAL4^slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte.

(Medioni and Noselli, 2005)

Expression of dome^{ΔTMCYT.Scer\UAS} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in segmentation defects in approximately 50% of embryos. The most frequent defects are deletions and fusions of segments A4 and A5.

(Brown et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^NP7397/dome^ΔTMCYT.UAS is a non-enhancer of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP7397, Src42A^CA.UAS

(Kohlmaier et al., 2015)

Suppressor of

Statement

Reference

dome^ΔTMCYT.UAS, Scer\GAL4^ap-md544 is a suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

Scer\GAL4^rn.PU/dome^ΔTMCYT.UAS, Scer\GAL80^elav.PU is a suppressor of abnormal developmental rate phenotype of Scer\GAL4^rn.PU, Scer\GAL80^elav.PU, upd3^UAS.GFP

(Romão et al., 2021)

dome^ΔTMCYT.UAS, Scer\GAL4^NP5130 is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of Egfr::tor^act.UAS, Scer\GAL4^NP5130

(Buchon et al., 2010)

NOT Suppressor of

Statement

Reference

Scer\GAL4^NP7397/dome^ΔTMCYT.UAS is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP7397, Src64B^UY1332

(Kohlmaier et al., 2015)

Scer\GAL4^NP7397/dome^ΔTMCYT.UAS is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP7397, Src42A^CA.UAS

(Kohlmaier et al., 2015)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^NP7397/dome^ΔTMCYT.UAS is a non-enhancer of adult midgut phenotype of Scer\GAL4^NP7397, Src42A^CA.UAS

(Kohlmaier et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL80^ts.αTub84B, dome^ΔTMCYT.UAS, Scer\GAL4^NP5130 is a suppressor | partially of midgut phenotype of Egfr::tor^act.UAS, Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

NOT Suppressor of

Statement

Reference

Scer\GAL4^NP7397/dome^ΔTMCYT.UAS is a non-suppressor of adult midgut phenotype of Scer\GAL4^NP7397, Src64B^UY1332

(Kohlmaier et al., 2015)

Scer\GAL4^NP7397/dome^ΔTMCYT.UAS is a non-suppressor of adult midgut phenotype of Scer\GAL4^NP7397, Src42A^CA.UAS

(Kohlmaier et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The mitotic index in the gut of flies overexpressing Egfr::tor^act.Scer\UAS is decreased but not abolished when dome^{ΔTMCYT.Scer\UAS} is co-expressed under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B.

(Buchon et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

dome^ΔTMCYT.UAS/Scer\GAL4^unspecified fails to rescue dome^unspecified

(Brown et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dome ΔTM

(Medioni and Noselli, 2005)

dome^{ΔTMCYT.Scer\UAS}

dome^ΔTMCYT.UAS

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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