FB2024_03 , released June 25, 2024
Allele: Dmel\KrnUAS.cUa
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General Information
Symbol
Dmel\KrnUAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0144769
Feature type
allele
Associated gene
Dmel\Krn
Associated Insertion(s)
Carried in Construct
P{UAS-Krn.U}
Key Links
Transgenic product class
wild_type
(Urban et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Urban et al., 2002)
Mutagen
in vitro construct
(Urban et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Krn.U}
Cytology
Description

Expression of full length Krn is under the control of UASt sequences.

(Urban et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Krn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing KrnScer\UAS.cUa under the control of Scer\GAL4GMR.PF have rough eyes and ectopic wing veins.

      (Brown et al., 2007)

      When KrnScer\UAS.cUa is driven by Scer\GAL4sev.EP disruption in the organisation of ommatidia is seen, most ommatidia are misrotated showing both under and over-rotations, though correct chirality is retained. Photoreceptor recruitment is not affected, though over-recruitment of cone cells is seen. R3/R4 specification and ommatidial rotation phenotypes are not visible in the third instar larval eye disc. The rotation defects occur sometime between 6 and 30 hours pot-pupariation. Ommatidial misrotations are also seen if KrnScer\UAS.cUa is driven by Scer\GAL4hs.PB. Heat shocking these animals at various points during development shows that Krn's effect on misrotation occurs very soon after its role in photoreceptor recruitment. This corresponds to s period during or after the second 45oC rotation, seen by ommatidia during the imaginal disc stage.

      (Brown and Freeman, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      KrnUAS.cUa/Scer\GAL4sev.EP is a non-enhancer of abnormal cell polarity phenotype of nmoP1

      (Brown and Freeman, 2003)
      NOT Suppressor of
      Statement
      Reference

      KrnUAS.cUa/Scer\GAL4sev.EP is a non-suppressor of abnormal cell polarity phenotype of nmoP1

      (Brown and Freeman, 2003)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      KrnUAS.cUa/Scer\GAL4sev.EP is a non-enhancer of ommatidium phenotype of nmoP1

      (Brown and Freeman, 2003)
      NOT Suppressor of
      Statement
      Reference

      KrnUAS.cUa/Scer\GAL4sev.EP is a non-suppressor of ommatidium phenotype of nmoP1

      (Brown and Freeman, 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      KrnUAS.cUa is rescued by KrnRNAi.UAS/Scer\GAL4GMR.PF

      (Brown et al., 2007)
      Comments

      Expression of KrndsRNA.Scer\UAS suppresses the rough eye and ectopic wing venation phenotypes seen in KrnScer\UAS.cUa, Scer\GAL4GMR.PF flies.

      (Brown et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      KrnScer\UAS.cUa
      KrnUAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)