FB2024_03 , released June 25, 2024
Allele: Dmel\MrtfUAS.cSa
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General Information
Symbol
Dmel\MrtfUAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Somogyi
FlyBase ID
FBal0160163
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-mal-d
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of a full length Mrtf cDNA.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of MrtfScer\UAS.cSa in the wing using Scer\GAL4Bx-MS1096 increases wing size relative to controls. The rate of cell-doubling is reduced in these animals.

Expression of MrtfScer\UAS.cSa under the control of Scer\GAL4slbo.2.6 results in ectopic F-actin accumulation in the cytoplasm of follicle cells. Expression of MrtfScer\UAS.cSa under the control of Scer\GAL4slbo.2.6 results in severe defects in border follicle cell migration.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference
NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing size in animals expressing both picoScer\UAS.T:Zzzz\His6,T:Hsap\MYC and MrtfScer\UAS.cSa in the wing using Scer\GAL4Bx-MS1096 resembles overexpression of MrtfScer\UAS.cSa alone.

MrtfScer\UAS.cSa-mediated overgrowth of the wing (under Scer\GAL4Bx-MS1096 control) can not be suppressed by ectopic picoIR.Scer\UAS expression.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
MrtfScer\UAS.cSa
MrtfUAS.cSa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Somogyi
Secondary FlyBase IDs
    References (5)