FlyBase Allele Report: Dmel\Octβ2R[f05679]

General Information

Symbol

Dmel\Octβ2R^f05679

Species

D. melanogaster

Name

FlyBase ID

FBal0161089

Feature type

allele

Associated gene

Dmel\Octβ2R

Associated Insertion(s)

PBac{WH}Octβ2R^f05679

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{WH}Octβ2R^f05679

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:12,553,839..12,553,902 [+]

(Zhao et al., 2021, Wu et al., 2013, Koon et al., 2011, Crocker et al., 2010, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Octβ2R^f05679 females lay significantly fewer eggs (all of which fail to develop as they are unfertilized and have only one nucleus) than wild type. Octβ2R^f05679 flies have similar but delayed copulation rates, compared to wild type. Ovaries in Octβ2R^f05679 females (both young and old) are significantly larger than in controls and contain more eggs in a row (up to 5, rather than the 2 seen in controls).

(Li et al., 2015)

The number of natural synaptopods (motile filopodia-like extensions) at type II neuromuscular junctions is significantly decreased in mutant third instar larvae compared to wild type. The number of type II boutons at the neuromuscular junction is also decreased in these larvae.

Type II neuromuscular junctions in mutant third instar larvae show an increase in the number of natural synaptopods in response to forskolin, as occurs in wild-type controls.

(Koon and Budnik, 2012)

The number of natural synaptopods is significantly decreased in Octβ2R^f05679 mutants. Accordingly, Octβ2R^f05679 mutants do not show increased numbers of synaptopods in response to octopamine.

Octβ2R^f05679 mutants show a reduction in evoked EJP amplitude compared to controls.

Octβ2R^f05679 mutants do not display increased locomotor speed in response to starvation.

Octβ2R^f05679 mutants exhibit a reduction in the number of type I boutons.

(Koon et al., 2011)

Octβ2R^f05679 mutants do not exhibit a disruption to nighttime sleep but do exhibit a significant decrease in daytime sleep, resulting in an overall reduction in sleep.

(Crocker et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Octβ2R^f05679 has female sterile | recessive phenotype, suppressible by Scer\GAL4^Oamb.4.4/Pka-C1^UAS.cKa

(Lim et al., 2014)

Octβ2R^f05679 has decreased fecundity | recessive | female phenotype, suppressible | partially by Scer\GAL4^Oamb.4.4/Pka-C1^UAS.cKa

(Lim et al., 2014)

Octβ2R^f05679 has female sterile | recessive phenotype, suppressible by Scer\GAL4^Oamb.4.4/CaMKII^UAS.cKa

(Lim et al., 2014)

Octβ2R^f05679 has decreased fecundity | recessive | female phenotype, suppressible | partially by Scer\GAL4^Oamb.4.4/CaMKII^UAS.cKa

(Lim et al., 2014)

Octβ2R^f05679 has decreased fecundity | recessive | female phenotype, suppressible | partially by Oamb^UAS.AS/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has decreased fecundity | recessive | female phenotype, suppressible | partially by Scer\GAL4^Oamb.4.4/Oamb^UAS.K3

(Lim et al., 2014)

Octβ2R^f05679 has female sterile | recessive phenotype, suppressible by Octβ1R^UAS.cLa/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has decreased fecundity | recessive | female phenotype, suppressible by Octβ1R^UAS.cLa/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has decreased fecundity | recessive | female phenotype, suppressible | partially by Octβ3R^UAS.cLa/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Octβ1R¹

(Koon and Budnik, 2012)

NOT suppressed by

Statement

Reference

Octβ2R^f05679 has female sterile | recessive phenotype, non-suppressible by Oamb^UAS.AS/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has female sterile | recessive phenotype, non-suppressible by Scer\GAL4^Oamb.4.4/Oamb^UAS.K3

(Lim et al., 2014)

Octβ2R^f05679 has female sterile | recessive phenotype, non-suppressible by Octβ3R^UAS.cLa/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Suppressor of

Statement

Reference

Octβ2R^f05679 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Octβ1R¹

(Koon and Budnik, 2012)

Other

Statement

Reference

Oamb²⁸⁶, Octβ2R^f05679 has female semi-fertile phenotype

(Lim et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Octβ2R^f05679 has egg | decreased number phenotype, suppressible | partially by Scer\GAL4^Oamb.4.4/CaMKII^UAS.cKa

(Lim et al., 2014)

Octβ2R^f05679 has egg | decreased number phenotype, suppressible | partially by Oamb^UAS.AS/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has egg | decreased number phenotype, suppressible | partially by Scer\GAL4^Oamb.4.4/Oamb^UAS.K3

(Lim et al., 2014)

Octβ2R^f05679 has egg | decreased number phenotype, suppressible by Octβ1R^UAS.cLa/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has egg | decreased number phenotype, suppressible | partially by Octβ3R^UAS.cLa/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 has egg | decreased number phenotype, suppressible | partially by Scer\GAL4^Oamb.4.4/Pka-C1^UAS.cKa

(Lim et al., 2014)

Octβ2R^f05679 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Octβ1R¹

(Koon and Budnik, 2012)

Octβ2R^f05679 has type II bouton | third instar larval stage phenotype, suppressible by Octβ1R¹

(Koon and Budnik, 2012)

Suppressor of

Statement

Reference

Octβ2R^f05679 is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Octβ1R¹

(Koon and Budnik, 2012)

Octβ2R^f05679 is a suppressor of type II bouton | increased number | third instar larval stage phenotype of Octβ1R¹

(Koon and Budnik, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The ability of TrpA1^{Scer\UAS.(B).cKa} expressed under the control of Scer\GAL4^Tdc2.PC at 31[o]C contingent with odour presentation to induce appetitive olfactory memory is impaired in a Octβ2R^f05679/+ background if the flies are satiated but not if the flies are hungry.

(Burke et al., 2012)

The number of natural synaptopods (motile filopodia-like extensions) and type II boutons at the type II neuromuscular junction in Octβ2R^f05679 oa2¹ double mutants is significantly higher than that seen in Octβ2R^f05679 single mutants and is similar to the number in wild-type controls.

(Koon and Budnik, 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Octβ2R^f05679 is rescued by Octβ2R^UAS.EGFP/Scer\GAL4^Oamb.4.4

(Lim et al., 2014)

Octβ2R^f05679 is rescued by Octβ2R^UAS.EGFP/Scer\GAL4^hs.PB

(Lim et al., 2014)

Octβ2R^f05679 is rescued by Scer\GAL4^Oamb.4.4/Octβ2R^UAS.cLa

(Lim et al., 2014)