FB2024_03 , released June 25, 2024
Allele: Dmel\mir-7UAS.cLb
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General Information
Symbol
Dmel\mir-7UAS.cLb
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct b of Li
FlyBase ID
FBal0193850
Feature type
allele
Associated gene
Dmel\mir-7
Associated Insertion(s)
Carried in Construct
P{UAS-mir-7.Lb}
Also Known As
UAS-miR-7
Key Links
Transgenic product class
wild_type
(Li and Carthew, 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Li and Carthew, 2005)
Mutagen
in vitro construct
(Li and Carthew, 2005)
Progenitor genotype
Carried in construct
P{UAS-mir-7.Lb}
Cytology
Description

UASt regulatory sequences drive expression of a 432bp fragment containing the mir-7 precursor. The mir-7 fragment contains no HnRNP-K coding sequence.

(Li and Carthew, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mir-7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing mir-7Scer\UAS.cLb under the control of Scer\GAL4ey.PH does not cause any overt eye overgrowth.

      (Da Ros et al., 2013)

      The number of spermatogonial cysts per testis is increased in males expressing mir-7Scer\UAS.cLb under the control of Scer\GAL4nos.PG compared to control males.

      (Pek et al., 2009)

      Expression of mir-7Scer\UAS.cLb under the control of Scer\GAL4GMR.PF leads to rough eyes. Expression in the larval eye disc causes the production of ectopic R7 photoreceptor neurons in ommatidia, which can still be observed at later stages of eye development.

      (Li and Carthew, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of mir-7Scer\UAS.cLb and DlScer\UAS.cDa under the control of Scer\GAL4ey.PH results in overgrown eye discs, resulting in overgrown and folded eyes in 70% of flies.

      Expression of boiScer\UAS.cHa fully suppresses the eye disc overgrowth seen when mir-7Scer\UAS.cLb and DlScer\UAS.cDa are co-expressed under the control of Scer\GAL4ey.PH.

      Expression of hhScer\UAS.cCa suppresses the eye overgrowth phenotype seen when DlScer\UAS.cDa and mir-7Scer\UAS.cLb are expressed under the control of Scer\GAL4ey.PH. The phenotype is seen with 100% penetrance.

      Expression of ciScer\UAS.T:Ivir\HA1 partially suppresses the eye overgrowth phenotype seen when DlScer\UAS.cDa and mir-7Scer\UAS.cLb are expressed under the control of Scer\GAL4ey.PH. Many eyes are substantially reduced in size but still exhibit abnormal patterned growth.

      (Da Ros et al., 2013)

      The increase in the number of spermatogonial cysts per testis that is seen in males expressing mir-7Scer\UAS.cLb under the control of Scer\GAL4nos.PG is suppressed if they are also expressing bamhs.PO.

      (Pek et al., 2009)

      Coexpression of the EgfrDN.Scer\UAS and mir-7Scer\UAS.cLb transgenes, under the control of Scer\GAL4GMR.PF, results in ommatidia with ectopic photoreceptor cells. The positions of these cells suggest they are R3 and R4.

      (Li and Carthew, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mir-7Scer\UAS.cLb
      mir-7UAS.cLb
      Name Synonyms
      Saccharomyces cerevisiae UAS construct b of Li
      Secondary FlyBase IDs
        References (4)