FlyBase Allele Report: Dmel\Snoo[UAS.cTa]

General Information

Symbol

Dmel\Snoo^UAS.cTa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct of Takaesu

FlyBase ID

FBal0196167

Feature type

allele

Associated gene

Dmel\Snoo

Associated Insertion(s)

Carried in Construct

P{UAS-Snoo.T}

Also Known As

UAS.dSno

Key Links

Transgenic product class

wild_type

(Takaesu et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Takaesu et al., 2006)

Mutagen

in vitro construct

(Takaesu et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Snoo.T}

Cytology

Description

UASt regulatory sequences drive expression of the Snoo SnoI isoform.

(Takaesu et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Snoo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^A9

(Takaesu et al., 2006)

Phenotype Manifest In

crossvein, with Scer\GAL4^A9

(Takaesu et al., 2006)

imaginal disc, with Scer\GAL4^32B

(Takaesu et al., 2006)

wing, with Scer\GAL4^A9

(Takaesu et al., 2006)

wing, with Scer\GAL4^T80

(Takaesu et al., 2012)

wing disc, with Scer\GAL4^A9

(Takaesu et al., 2006)

wing vein, with Scer\GAL4^A9

(Takaesu et al., 2006)

wing vein L3, with Scer\GAL4^A9

(Fischer et al., 2012)

wing vein L4, with Scer\GAL4^A9

(Fischer et al., 2012)

Detailed Description

Statement

Reference

Expression of Snoo^Scer\UAS.cTa using Scer\GAL4^A9 results in loss of wing vein L4 from the posterior crossvein on towards the wing margin, while L3 is only rudimentary and stunted in growth

(Fischer et al., 2012)

Expression of Snoo^Scer\UAS.cTa in the wing discs under the control of Scer\GAL4^T80 leads to wing vein truncation.

(Takaesu et al., 2012)

Expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^A9 results in small wings with multiple vein truncations (this phenotype is 100% penetrant).

The pupal wing disc is smaller than normal in animals expressing Snoo^Scer\UAS.cTa under the control of Scer\GAL4^A9.

Expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^32B results in larvae that lack imaginal discs.

(Takaesu et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^A9, Snoo^UAS.cTa has visible phenotype, enhanceable by Mad^1.UAS, Scer\GAL4^A9

(Takaesu et al., 2006)

Suppressed by

Statement

Reference

Scer\GAL4^A9, Snoo^UAS.cTa has visible phenotype, suppressible | partially by Med^UAS.cSa, Scer\GAL4^A9

(Takaesu et al., 2006)

Scer\GAL4^A9, Snoo^UAS.cTa has visible phenotype, suppressible | partially by Mad^UAS.cNa, Scer\GAL4^A9

(Takaesu et al., 2006)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, Snoo^UAS.cTa has visible phenotype, non-suppressible by Scer\GAL4^A9/Smox^UAS.cZa

(Takaesu et al., 2006)

Suppressor of

Statement

Reference

Snoo^UAS.cTa/Scer\GAL4^A9 is a suppressor of visible phenotype of Scer\GAL4^A9, tkv^{Q199D.UAS.Tag:HA}

(Takaesu et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^A9, Snoo^UAS.cTa has wing phenotype, enhanceable by Mad^1.UAS, Scer\GAL4^A9

(Takaesu et al., 2006)

Scer\GAL4^A9, Snoo^UAS.cTa has wing vein phenotype, enhanceable by Mad^1.UAS, Scer\GAL4^A9

(Takaesu et al., 2006)

Suppressed by

Statement

Reference

Scer\GAL4^A9, Snoo^UAS.cTa has wing phenotype, suppressible | partially by Med^UAS.cSa, Scer\GAL4^A9

(Takaesu et al., 2006)

Scer\GAL4^A9, Snoo^UAS.cTa has wing phenotype, suppressible | partially by Mad^UAS.cNa, Scer\GAL4^A9

(Takaesu et al., 2006)

Scer\GAL4^A9, Snoo^UAS.cTa has wing vein phenotype, suppressible | partially by Med^UAS.cSa, Scer\GAL4^A9

(Takaesu et al., 2006)

Scer\GAL4^A9, Snoo^UAS.cTa has wing vein phenotype, suppressible | partially by Mad^UAS.cNa, Scer\GAL4^A9

(Takaesu et al., 2006)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, Snoo^UAS.cTa has wing phenotype, non-suppressible by Scer\GAL4^A9/Smox^UAS.cZa

(Takaesu et al., 2006)

Scer\GAL4^A9, Snoo^UAS.cTa has wing vein phenotype, non-suppressible by Scer\GAL4^A9/Smox^UAS.cZa

(Takaesu et al., 2006)

Suppressor of

Statement

Reference

Snoo^UAS.cTa/Scer\GAL4^A9 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^A9, tkv^{Q199D.UAS.Tag:HA}

(Takaesu et al., 2006)

Snoo^UAS.cTa/Scer\GAL4^A9 is a suppressor of wing phenotype of Scer\GAL4^A9, tkv^{Q199D.UAS.Tag:HA}

(Takaesu et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Med^Scer\UAS.cSa partially rescues the phenotype caused by expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^A9; wing size is rescued to wild type and the penetrance of the multiple wing vein defects is reduced to 28%.

Co-expression of Mad^Scer\UAS.cNa partially rescues the phenotype caused by expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^A9; wing size is rescued to wild type and the penetrance of the multiple wing vein defects is reduced to 19%.

Co-expression of Smox^Scer\UAS.cZa has little effect on the wing phenotypes caused by expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^A9.

Co-expression of Mad^1.Scer\UAS significantly enhances the wing phenotypes caused by expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^A9; the wing is very small and veinless in the co-expressing flies.

The wing phenotypes caused by expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^A9 are suppressed by co-expression of Snoo^Scer\UAS.cTa; the wing in the co-expressing flies appears similar to the phenotype seen in flies expressing Snoo^Scer\UAS.cTa alone under the control of Scer\GAL4^A9.

(Takaesu et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Snoo^UAS.cTa/Scer\GAL4^hs.PB partially rescues Snoo^SH1402

(Takaesu et al., 2006)

Snoo^UAS.cTa/Scer\GAL4^hs.PB partially rescues Snoo^SH1402/Snoo^EX4B

(Takaesu et al., 2006)

Snoo^UAS.cTa/Scer\GAL4^hs.PB partially rescues Snoo^EX4B/Snoo^EX17B

(Takaesu et al., 2006)

Snoo^UAS.cTa/Scer\GAL4^hs.PB partially rescues Snoo^SH1402/Snoo^EX17B

(Takaesu et al., 2006)

Snoo^UAS.cTa/Scer\GAL4^hs.PB partially rescues Snoo^EX17B

(Takaesu et al., 2006)

Fails to rescue

Snoo^UAS.cTa/Scer\GAL4^hs.PB fails to rescue Snoo^EX4B

(Takaesu et al., 2006)

Comments

Expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^hs.PB using heat shock can rescue Snoo^SH1402/Snoo^SH1402, Snoo^SH1402/Snoo^EX4B and Snoo^EX4B/Snoo^EX17B flies to adulthood, although only males are obtained, and they have wing defects.

Expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^hs.PB using heat shock can rescue Snoo^SH1402/Snoo^EX17B and Snoo^EX17B/Snoo^EX17B flies to adulthood (both males and females are obtained), and they have wing defects.

Expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^hs.PB using heat shock fails to rescue Snoo^EX4B/Snoo^EX4B flies to adulthood.

(Takaesu et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Snoo^Scer\UAS.cTa

Snoo^UAS.cTa

Name Synonyms

Saccharomyces cerevisiae UAS construct of Takaesu

Secondary FlyBase IDs

References (3)

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