FlyBase Allele Report: Dmel\Chmp1[GD11219]

General Information

Symbol

Dmel\Chmp1^GD11219

Species

D. melanogaster

Name

FlyBase ID

FBal0206574

Feature type

allele

Associated gene

Dmel\Chmp1

Associated Insertion(s)

Carried in Construct

P{GD11219}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11219}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11219

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity, with Scer\GAL4^en.PU

(Valentine et al., 2014)

partially lethal - majority die, with Scer\GAL4^Act5C.PU

(Valentine et al., 2014)

partially lethal - majority die, with Scer\GAL4^Tub.PU

(Valentine et al., 2014)

short lived, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

visible, with Scer\GAL4^en.PU

(Valentine et al., 2014)

visible, with Scer\GAL4^ptc.PU

(Valentine et al., 2014)

Phenotype Manifest In

1st posterior cell, with Scer\GAL4^ptc.PU

(Valentine et al., 2014)

wing, with Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

wing hair, with Scer\GAL4^en.PU

(Valentine et al., 2014)

wing vein L3, with Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

wing vein L4, with Scer\GAL4^en.PU

(Valentine et al., 2014)

wing vein L4 | distal, with Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

wing vein L5, with Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

wing vein L5, with Scer\GAL4^en.PU

(Valentine et al., 2014)

Detailed Description

Statement

Reference

Expression of Chmp1^GD11219 under the control of Scer\GAL4^Act5C.PU or Scer\GAL4^tub.PU results in lethality at or before the pupal stage. Occasional female escapers are seen, which have phenotypes including thickened wing veins, rough eyes and a general failure to thrive.

Expression of Chmp1^GD11219 under the control of Scer\GAL4^Bx-MS1096 results in thickening of all dorsal wing veins (L3, L5 and distal L4) at 28[o]C. At 30[o]C it is difficult to distinguish between vein and intervein tissue.

Expression of Chmp1^GD11219 under the control of Scer\GAL4^ptc.PU results in some intervein cells between veins L3 and L4 adopting a vein fate at the distal end of the wing.

Expression of Chmp1^GD11219 under the control of Scer\GAL4^en.PU results in thickening of veins L4 and L5. Cells with additional wing hairs and altered wing hair polarity are also seen adjacent to the anterior boundary of Scer\GAL4^en.PU expression.

(Valentine et al., 2014)

Adults expressing Chmp1^GD11219 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in lethality by 7 days after eclosion.

(Schnorrer et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by Df(3L)BSC416/+

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by aos[+]/aos^Δ7

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by sty[+]/sty^Δ5

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by Df(3L)BSC832/+

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by kek1[+]/kek1^DG23812

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by aos[+]/aos^rlt

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by aos[+]/aos^W11

(Valentine et al., 2014)

Suppressed by

Statement

Reference

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by vn[+]/vn¹

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by vn[+]/rho^ve-1/vn¹/rho[+]

(Valentine et al., 2014)

NOT suppressed by

Statement

Reference

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has visible phenotype, non-suppressible by rho^ve-1/rho[+]

(Valentine et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by Df(3L)BSC416/+

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by aos[+]/aos^Δ7

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by sty[+]/sty^Δ5

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by Df(3L)BSC832/+

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by kek1[+]/kek1^DG23812

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by aos[+]/aos^rlt

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by aos[+]/aos^W11

(Valentine et al., 2014)

Suppressed by

Statement

Reference

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, suppressible by vn[+]/vn¹

(Valentine et al., 2014)

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, suppressible by vn[+]/rho^ve-1/vn¹/rho[+]

(Valentine et al., 2014)

NOT suppressed by

Statement

Reference

Chmp1^GD11219, Scer\GAL4^Bx-MS1096 has wing vein phenotype, non-suppressible by rho^ve-1/rho[+]

(Valentine et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Chmp1^GD11219 is partially rescued by Chmp1^UAS.cVa/Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

Chmp1^GD11219 is partially rescued by Chmp1^{UAS.Tag:polyHis,Tag:MYC}/Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

Comments

Co-expression of either Chmp1^Scer\UAS.cVa or Chmp1^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} partially rescues the wing vein phenotype caused by expression of Chmp1^GD11219 under the control of Scer\GAL4^Bx-MS1096.

(Valentine et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v21788

w¹¹¹⁸; P{GD11219}v21788/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Chmp1^GD11219

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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