FlyBase Allele Report: Dmel\aos[Δ7]

General Information

Symbol

Dmel\aos^Δ7

Species

D. melanogaster

Name

FlyBase ID

FBal0043093

Feature type

allele

Associated gene

Dmel\aos

Associated Insertion(s)

Carried in Construct

Also Known As

argos^IΔ7, argos^Δ7, argos^lΔ7, argos^delta7, aos^d7, argos^1Δ7, arg^1Δ7, aos^lΔ7

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Stemerdink and Jacobs, 1997, Schweitzer et al., 1995, Wemmer and Klämbt, 1995, Freeman et al., 1992)

loss of function allele

(Szuts et al., 1997)

Mutagen

Delta2-3 transposase

(Freeman et al., 1992)

P-element activity

(Stemerdink and Jacobs, 1997, Wemmer and Klämbt, 1995)

Progenitor genotype

aos^W11

(Stemerdink and Jacobs, 1997, Freeman et al., 1992)

Cytology

Description

Excision of the P{lwB} element.

(Stemerdink and Jacobs, 1997)

Excision of a P-element causing deletion of the first exon encoding the putative ATG start codon and signal sequence.

(Wemmer and Klämbt, 1995)

Deletion caused by imprecise excision of the P{lwB} element of argos^W11. Deletion removes the 5' exon and the beginning of the major open reading frame.

(Freeman et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity (with aos^5F4)

(Strutt and Strutt, 2003, Strutt and Strutt, 2003)

abnormal cell polarity (with aos^A254Δ15)

(Strutt and Strutt, 2003)

abnormal cell polarity (with aos^rlt)

(Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003)

abnormal neuroanatomy | third instar larval stage

(Morante et al., 2013)

lethal

(Schweitzer et al., 1995)

lethal (with Df(3L)st-f13)

(Wemmer and Klämbt, 1995)

lethal (with Df(3L)st-k7)

(Wemmer and Klämbt, 1995)

lethal - all die during embryonic stage (with Df(3L)st-g18)

(Wemmer and Klämbt, 1995)

lethal - all die during embryonic stage | recessive

(Freeman et al., 1992)

some die during embryonic stage (with Df(3L)st-g18)

(Wemmer and Klämbt, 1995)

some die during embryonic stage | recessive

(Freeman et al., 1992)

visible (with aos²⁵⁷)

(Zartman et al., 2009)

visible (with aos^p1)

(Zartman et al., 2009)

visible (with aos^W11)

(Zartman et al., 2009)

visible (with Df(3L)Exel6129)

(Alvarado et al., 2006)

Phenotype Manifest In

1st posterior cell

(Palsson and Gibson, 2000)

2nd posterior cell

(Palsson and Gibson, 2000)

abdominal lateral pentascolopidial chordotonal organ lch5 | increased number

(Elstob et al., 2001)

adult optic lobe

(Dumstrei et al., 1998)

chordotonal organ | lateral

(Scholz et al., 1997, Scholz et al., 1997)

dorsal acute muscle cell | ectopic

(Carmena et al., 2002)

dorsal acute muscle cell | ectopic | precursor

(Carmena et al., 2002)

dorsal appendage (with aos^W11)

(Wasserman and Freeman, 1998)

dorsal appendage | maternal effect (with aos^W11)

(Zartman et al., 2009)

dorsal appendage | somatic clone

(Wasserman and Freeman, 1998)

dorsal oblique muscle cell | ectopic

(Carmena et al., 2002)

dorsal oblique muscle cell | ectopic | precursor

(Carmena et al., 2002)

embryonic/larval brain | third instar larval stage

(Morante et al., 2013)

embryonic/larval oenocyte | increased number

(Brodu et al., 2004, Elstob et al., 2001)

embryonic/larval oenocyte precursor | increased number

(Brodu et al., 2004)

embryonic/larval optic lobe

(Daniel et al., 1999)

embryonic/larval recurrent nerve

(Dumstrei et al., 1998)

embryonic head

(Freeman et al., 1992)

embryonic ventral epidermis

(Freeman et al., 1992)

eye (with aos²⁵⁷)

(Zartman et al., 2009)

eye (with aos^p1)

(Zartman et al., 2009)

eye (with aos^W11)

(Zartman et al., 2009)

eye (with Df(3L)Exel6129)

(Alvarado et al., 2006)

eye (with Df(3L)st-f13)

(Wemmer and Klämbt, 1995)

eye (with Df(3L)st-k7)

(Wemmer and Klämbt, 1995)

eye | posterior (with aos⁰⁵⁸⁴⁵)

(Voas and Rebay, 2003)

eye | somatic clone

(Freeman et al., 1992)

eye photoreceptor cell | ectopic (with aos^5F4)

(Strutt and Strutt, 2003)

eye photoreceptor cell | ectopic (with aos^A254Δ15)

(Strutt and Strutt, 2003)

eye photoreceptor cell | ectopic (with aos^rlt)

(Strutt and Strutt, 2003)

eye photoreceptor cell | somatic clone | increased number

(Charroux et al., 2006)

frontal ganglion

(Dumstrei et al., 1998)

genital disc primordium

(Chen et al., 2005)

hypocerebral ganglion

(Dumstrei et al., 1998)

hypostomal sclerite

(Shandala et al., 1999)

larval neuroblast | ectopic | third instar larval stage

(Morante et al., 2013)

midline glial cell

(Scholz et al., 1997, Scholz et al., 1997, Stemerdink and Jacobs, 1997)

mystery cell (with aos^5F4)

(Strutt and Strutt, 2003)

oenocyte primordium

(Brodu et al., 2004)

ommatidial precursor cluster (with aos^5F4)

(Strutt and Strutt, 2003)

ommatidium (with aos^5F4)

(Strutt and Strutt, 2003)

ommatidium (with aos^A254Δ15)

(Strutt and Strutt, 2003)

ommatidium (with aos^rlt)

(Gaengel and Mlodzik, 2003, Strutt and Strutt, 2003)

pericardial cell | ectopic

(Carmena et al., 2002)

pericardial cell | ectopic | precursor

(Carmena et al., 2002)

photoreceptor cell R1 | somatic clone

(Freeman et al., 1992)

photoreceptor cell R2 | somatic clone

(Freeman et al., 1992)

photoreceptor cell R3 | ectopic (with aos^5F4)

(Strutt and Strutt, 2003)

photoreceptor cell R3 | somatic clone

(Freeman et al., 1992)

photoreceptor cell R4 | ectopic (with aos^5F4)

(Strutt and Strutt, 2003)

photoreceptor cell R4 | somatic clone

(Freeman et al., 1992)

photoreceptor cell R5 | somatic clone

(Freeman et al., 1992)

photoreceptor cell R6 | somatic clone

(Freeman et al., 1992)

photoreceptor cell R8 | somatic clone

(Yang and Baker, 2001)

presumptive embryonic/larval central nervous system

(Scholz et al., 1997, Scholz et al., 1997)

ventral denticle belt

(Szuts et al., 1997)

ventral denticle belt (with aos^Δ5)

(Simcox, 1997)

Detailed Description

Statement

Reference

The neuroepithelium of aos^Δ7 L3 larvae is overgrown compared to wild type. In the subsequent stage, ectopic and precocious neuroblasts are scattered throughout this enlarged neuroepithelium.

(Morante et al., 2013)

Virtually all eggs derived from egg chambers containing complete homozygous follicle cell clones appear normal and have two dorsal appendages.

(Lachance et al., 2009)

argos^Δ7/+ flies have normal eyes at 20[o]C.

(Mao and Freeman, 2009)

argos^Δ7/argos²⁵⁷, argos^Δ7/argos^W11 and argos^Δ7/argos^p1 flies have blisters in the eye.

Eggs derived from females with mosaic argos^Δ7 egg chambers have the normal number of two dorsal appendages.

Only 5% of eggs derived from argos^Δ7/argos^W11 females have defects in dorsal appendage morphology, which include a reduced distance between the two appendages and appendages that are shorter than normal.

(Zartman et al., 2009)

argos^Δ7/Df(3L)Exel6129 flies have eyes with a roughened appearance and prominent blistering along the posterior margin.

(Alvarado et al., 2006)

argos^Δ7 clones in the eye disc induce the formation of extra photoreceptor cells; 46.2% of ommatidia within these clones have 8 photoreceptor cells, 40.7% of ommatidia have 9, 11.1% have 10 and 1% have 11.

(Charroux et al., 2006)

Stage 15 argos^Δ7 embryos have ~36 genital disc precursor cells, while wild type embryos have only 22 at this stage.

(Chen et al., 2005)

Stage 16 argos^Δ7 homozygous embryos have more oenocytes per cluster than wild-type. Unlike rho^{Scer\UAS.cdCa}; Scer\GAL4^en-e16E the oenocyte clusters in these embryos do not show a multi-modal distribution of cell numbers with peaks corresponding to multiples of 3. Analysis of larval oenocyte precursor delamination shows that it occurs continuously rather than in widely spaced cycles with 3 delaminating cells per cycle as seen in wild-type. In the resulting oenocyte clusters terminal differentiation of some oenocytes is blocked or delayed.

(Brodu et al., 2004)

argos^rlt/argos^Δ7 animals exhibit a ommatidial rotation phenotype.

(Gaengel and Mlodzik, 2003)

63% of ommatidia in argos^Δ7/argos^A254Δ15 animals exhibit extra R cells. Of those that ommatidia that remain about 47% exhibit misrotations, about 10% exhibit achirality, and about 4% exhibit the wrong chirality. About 43% of ommatidia in argos^Δ7/argos^5F4 animals exhibit extra R cells. Of those that ommatidia that remain about 45% exhibit misrotations, about 5% exhibit achirality, and none exhibit the wrong chirality. About 11% of ommatidia in argos^Δ7/argos^rlt animals exhibit extra R cells. Of those that ommatidia that remain about 52% exhibit misrotations, about 1% exhibit achirality, and about 1% exhibit the wrong chirality. Of the misrotated ommatidia just less than half are underrotated.

(Strutt and Strutt, 2003)

In argos^5F4/argos^Δ7 transheterozygotes 45% of adult ommatidia have extra photoreceptors. Many of the ommatidia with a normal complement of photoreceptor cells have polarity defects up to 59% of ommatidia are misrotated, while only 5% appear achiral and usually less than 1% have the wrong chirality. It appears that a transformation of mystery cells to photoreceptor R3/R4 is the cause of the extra photoreceptor cells. When the eye discs of these mutants are examined about 60% of immature clusters exhibit extra photoreceptor precursor cells. In row 7-8 the number of extra cells decreases to about 25%. In the adult only about 15% of clusters have ectopic R3/R4 cells.

(Strutt and Strutt, 2003)

argos^Δ7/argos⁰⁵⁸⁴⁵ escaper adults have extensive blistering along the posterior edge of the eye.

(Voas and Rebay, 2003)

Extra EPCs (eve-positive heart associated or pericardial cells) and DA1 and DO2 founders (and subsequently muscles) are seen in mutant embryos. Additional founders of the P2 and p15 lineages of the developing embryonic mesoderm are seen.

(Carmena et al., 2002)

Homozygous clones in the adult abdomen do not show any consistent alterations of normal polarity.

(Lawrence et al., 2002)

Ommatidial spacing is not affected in argos^Δ7 somatic clones in the eye, even in very large clones.

(Baonza et al., 2001)

The number of chordotonal organs in the lateral cluster is increased from 5 to 6 in mutant embryos. In stage 11 embryos, the oenocyte precursor whorl is enlarged and contains many extra cells and by stage 16 oenocyte clusters containing 15-27 cells are seen.

(Elstob et al., 2001)

Homozygous clones in the eye disc that include several ommatidia show no defects in R8 precursor specification. Positioning of R8 precursors is unaffected by mutant cells in posterior columns. In larger clones that are more than 10 ommatidia wide the pattern of R8 specification is disrupted.

(Yang and Baker, 2001)

Heterozygotes show a quantitative effect on wing shape in intervein regions C and D compared to wild type.

(Palsson and Gibson, 2000)

Mutant embryos show a 'cyclops' phenotype in which the optic lobes are enlarged and show dorsal fusion.

(Daniel et al., 1999)

Homozygous embryos have missing or malformed H-piece structures.

(Shandala et al., 1999)

At stage 16 optic lobes are enlarged and fused. Frontal and hypocerebral ganglion are enlarged and the recurrens nerve is thickened.

(Dumstrei et al., 1998)

Germline clones fail to rescue the female sterile phenotype of Fs(3)Apc.

(Sapir et al., 1998)

Germline clones reveal no requirement for argos in the oocyte in patterning the egg, or in the viability or patterning of the embryo. Follicle cell clones cause a fused dorsal appendage phenotype. Larvae hatch from the eggs, with dorsal-ventral pattern unperturbed. argos^Δ7/argos^W11 hypomorphic females lay a significant proportion of eggs with fused dorsal appendages.

(Wasserman and Freeman, 1998)

Abnormal CNS axon pattern phenotype. An increase in number of midline glia and lateral chordotonal organs is also observed.

(Scholz et al., 1997, Scholz et al., 1997)

argos^Δ5/argos^Δ7 embryos exhibit expansion of the denticle belts. Wing, leg, haltere and eye/antenna argos^Δ5/argos^Δ7 mutant discs can be in vivo cultured.

(Simcox, 1997)

The number of midline glia cells is increased to an average of 5.3 +/- 0.2 cells per segment in homozygous embryos.

(Stemerdink and Jacobs, 1997)

Additional small denticles are often found located anteriorly to the abdominal denticle belts in homozygous embryos, in the most extreme cases forming a complete additional row anterior to row 1. Extra small denticles are also found in row 6, resulting in a slightly higher density of denticles compared to wild-type.

(Szuts et al., 1997)

Transheterozygotes with Df(3L)st-g18 die before hatching. Transheterozygotes with Df(3L)st-k7 or Df(3L)st-f13 have rare escapers, adult survivors develop a characteristic eye phenotype, bulging of the posterior part of the eye that spreads into the anterior part.

(Wemmer and Klämbt, 1995)

Homozygous clones in the eye cause extra outer photoreceptors, severity of the phenotype depends on the size of the clone. Homozygotes display severe disruption and broadening of the embryonic head skeleton, broadening of the ventral epidermis as shown by increased distance between the Keilin's organs.

(Freeman et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

aos[+]/aos^Δ7, sty^S73 has visible | dominant phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Zettl et al., 2011)

Enhancer of

Statement

Reference

aos[+]/aos^Δ7 is an enhancer of visible phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

aos[+]/aos^Δ7 is an enhancer of visible | dominant phenotype of Snr1^E1

(Curtis et al., 2011)

aos[+]/aos^Δ7 is an enhancer of abnormal size | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

aos[+]/aos^Δ7 is an enhancer of increased cell number | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

aos[+]/aos^Δ7 is an enhancer of visible | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

aos[+]/aos^Δ7 is an enhancer of visible | dominant phenotype of sty^S73

(Zettl et al., 2011)

aos[+]/aos^Δ7 is an enhancer of visible | dominant phenotype of rho-5[+]/rho-5^KO1, sty^S73

(Zettl et al., 2011)

aos[+]/aos^Δ7 is an enhancer of visible phenotype of Dg^RNAi.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

aos[+]/aos^Δ7 is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

aos^Δ7/argos[+] is an enhancer of abnormal planar polarity | recessive phenotype of sl⁹

(Schlesinger et al., 2004)

aos^Δ7 is an enhancer of abnormal cell polarity phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

aos^Δ7, argos[+], N[+], N^55e11 is an enhancer of abnormal planar polarity phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

aos^Δ7 is an enhancer of visible phenotype of bul¹

(Wemmer and Klämbt, 1995)

NOT Enhancer of

Statement

Reference

aos^Δ7/argos[+] is a non-enhancer of abnormal planar polarity phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

Suppressor of

Statement

Reference

aos[+], aos^Δ7, Ack^UAS.cSb, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of hid^Ala5.GMR

(Schoenherr et al., 2012)

aos[+]/aos^Δ7 is a suppressor of visible phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

aos^Δ7 is a suppressor of abnormal cell polarity phenotype of Ras64B^V14.Act5C

(Strutt and Strutt, 2003)

aos^Δ7 is a suppressor of lethal phenotype of hid^hs.PG

(Bergmann et al., 1998)

aos^Δ7 is a suppressor of visible phenotype of bul^D

(Wemmer and Klämbt, 1995)

NOT Suppressor of

Statement

Reference

aos[+]/aos^Δ7 is a non-suppressor of visible phenotype of hid^Ala5.GMR

(Schoenherr et al., 2012)

aos[+], aos^Δ7, Ack^K156A.UAS, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of hid^Ala5.GMR

(Schoenherr et al., 2012)

aos^Δ7 is a non-suppressor of decreased cell death phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

Other

Statement

Reference

aos^Δ7, sty^S73 has visible | dominant phenotype

(Casci et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

aos[+]/aos^Δ7, sty^S73 has wing vein phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Zettl et al., 2011)

aos^Δ7 has eye photoreceptor cell | increased number | somatic clone phenotype, enhanceable by Gug¹⁴⁹⁶⁷

(Charroux et al., 2006)

aos^Δ7/aos⁰⁵⁸⁴⁵ has eye phenotype, enhanceable by rno³/rno[+]

(Voas and Rebay, 2003)

aos^Δ7 has dorsal acute muscle cell | precursor | ectopic phenotype, enhanceable by Delta^X

(Carmena et al., 2002)

aos^Δ7 has pericardial cell | ectopic phenotype, enhanceable by Delta^X

(Carmena et al., 2002)

aos^Δ7 has pericardial cell | precursor | ectopic phenotype, enhanceable by Delta^X

(Carmena et al., 2002)

aos^Δ7 has dorsal acute muscle cell | ectopic phenotype, enhanceable by Delta^X

(Carmena et al., 2002)

aos^Δ7 has abdominal lateral pentascolopidial chordotonal organ lch5 | increased number phenotype, enhanceable by salm^unspecified

(Elstob et al., 2001)

Suppressed by

Statement

Reference

aos^Δ7 has dorsal acute muscle cell | ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.UAS

(Carmena et al., 2002)

aos^Δ7 has dorsal acute muscle cell | precursor | ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.UAS

(Carmena et al., 2002)

aos^Δ7 has dorsal oblique muscle cell | ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.UAS

(Carmena et al., 2002)

aos^Δ7 has dorsal oblique muscle cell | precursor | ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.UAS

(Carmena et al., 2002)

aos^Δ7 has pericardial cell | ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.UAS

(Carmena et al., 2002)

aos^Δ7 has pericardial cell | precursor | ectopic phenotype, suppressible by Scer\GAL4^twi.PB/Egfr^DN.UAS

(Carmena et al., 2002)

Enhancer of

Statement

Reference

aos[+]/aos^Δ7 is an enhancer of female germline cell | third instar larval stage phenotype of goe^5-11/goe³³¹

(Matsuoka et al., 2014)

aos[+]/aos^Δ7 is an enhancer of wing vein phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

aos^Δ7 is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, miple1^UAS.Tag:HA

(Muñoz-Soriano et al., 2013)

aos[+]/aos^Δ7 is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Curtis et al., 2011)

aos[+]/aos^Δ7 is an enhancer of wing blade phenotype of sl²

(Murillo-Maldonado et al., 2011)

aos[+]/aos^Δ7 is an enhancer of wing vein | ectopic phenotype of sl²

(Murillo-Maldonado et al., 2011)

aos[+]/aos^Δ7 is an enhancer of eye phenotype of sl²

(Murillo-Maldonado et al., 2011)

aos[+]/aos^Δ7 is an enhancer of photoreceptor cell R7 | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

aos[+]/aos^Δ7 is an enhancer of wing vein phenotype of sty^S73

(Zettl et al., 2011)

aos[+]/aos^Δ7 is an enhancer of wing vein phenotype of rho-5[+]/rho-5^KO1, sty^S73

(Zettl et al., 2011)

aos^Δ7 is an enhancer of eye phenotype of Fas2^EB112/Fas2^e76

(Mao and Freeman, 2009)

aos^Δ7/Scer\GAL4^Tub.PU is an enhancer of wing vein phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

aos[+]/aos^Δ7 is an enhancer of posterior crossvein phenotype of Dg^RNAi.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

aos[+]/aos^Δ7 is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

aos^Δ7/argos[+] is an enhancer of photoreceptor cell R7 | increased number phenotype of sl⁹

(Schlesinger et al., 2004)

aos^Δ7/argos[+] is an enhancer of ommatidium phenotype of sl⁹

(Schlesinger et al., 2004)

aos^Δ7/argos[+] is an enhancer of interommatidial bristle phenotype of sl⁹

(Schlesinger et al., 2004)

aos^Δ7/argos[+] is an enhancer of photoreceptor cell R8 | increased number phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7/argos[+] is an enhancer of photoreceptor cell R8 | increased number phenotype of ed^k01102

(Spencer and Cagan, 2003)

aos^Δ7 is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

aos^Δ7/argos[+] is an enhancer of ommatidium phenotype of Ras85D^V12.sev

(Voas and Rebay, 2003)

aos^Δ7/argos[+] is an enhancer of eye phenotype of Ras85D^V12.sev

(Voas and Rebay, 2003)

aos^Δ7, argos[+], N[+], N^55e11 is an enhancer of eye photoreceptor cell phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

aos^Δ7, argos[+], N[+], N^55e11 is an enhancer of ommatidium phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

aos^Δ7 is an enhancer of dorsal acute muscle cell | precursor | ectopic phenotype of Delta^X

(Carmena et al., 2002)

aos^Δ7 is an enhancer of pericardial cell | ectopic phenotype of Delta^X

(Carmena et al., 2002)

aos^Δ7 is an enhancer of pericardial cell | precursor | ectopic phenotype of Delta^X

(Carmena et al., 2002)

aos^Δ7 is an enhancer of dorsal acute muscle cell | ectopic phenotype of Delta^X

(Carmena et al., 2002)

aos^Δ7 is an enhancer of abdominal lateral pentascolopidial chordotonal organ lch5 | increased number phenotype of salm^unspecified

(Elstob et al., 2001)

aos^Δ7 is an enhancer of eye phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

aos^Δ7 is an enhancer of photoreceptor cell R7 phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

aos^Δ7 is an enhancer of wing vein | ectopic phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

aos^Δ7 is an enhancer of eye phenotype of Cbl^D.onc.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

aos^Δ7 is an enhancer of wing vein phenotype of Cbl^D.onc.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

aos^Δ7 is an enhancer of eye phenotype of bul¹

(Wemmer and Klämbt, 1995)

NOT Enhancer of

Statement

Reference

aos^Δ7 is a non-enhancer of eye phenotype of Scer\GAL4^hs.2sev, miple1^UAS.Tag:HA

(Muñoz-Soriano et al., 2013)

aos^Δ7 is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, miple1^UAS.Tag:HA

(Muñoz-Soriano et al., 2013)

aos^Δ7 is a non-enhancer of chemosensory ventral triple row & microchaeta | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7 is a non-enhancer of dorsal triple row & microchaeta | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7 is a non-enhancer of dorsocentral bristle | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7 is a non-enhancer of scutellar bristle | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7/argos[+] is a non-enhancer of eye photoreceptor cell phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

aos^Δ7/argos[+] is a non-enhancer of ommatidium phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

aos^Δ7/argos[+] is a non-enhancer of wing phenotype of N^55e11

(Weber et al., 2003)

Suppressor of

Statement

Reference

aos[+], aos^Δ7, Ack^UAS.cSb, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of hid^Ala5.GMR

(Schoenherr et al., 2012)

aos[+]/aos^Δ7 is a suppressor of posterior crossvein phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

aos^Δ7 is a suppressor of ommatidium phenotype of Ras64B^V14.Act5C

(Strutt and Strutt, 2003)

aos^Δ7 is a suppressor of pericardial cell phenotype of Egfr^DN.UAS, Scer\GAL4^twi.PB

(Carmena et al., 2002)

aos^Δ7 is a suppressor of dorsal oblique muscle cell phenotype of Egfr^DN.UAS, Scer\GAL4^twi.PB

(Carmena et al., 2002)

aos^Δ7 is a suppressor of eye phenotype of arm^S56F.GMR

(Freeman and Bienz, 2001)

aos^Δ7 is a suppressor of eye phenotype of hid^GMR.PG

(Bergmann et al., 1998)

aos^Δ7 is a suppressor of ommatidium phenotype of hid^GMR.PG

(Bergmann et al., 1998)

aos^Δ7 is a suppressor of eye phenotype of bul^D

(Wemmer and Klämbt, 1995)

NOT Suppressor of

Statement

Reference

aos[+]/aos^Δ7 is a non-suppressor of eye phenotype of hid^Ala5.GMR

(Schoenherr et al., 2012)

aos[+], aos^Δ7, Ack^K156A.UAS, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of hid^Ala5.GMR

(Schoenherr et al., 2012)

aos^Δ7 is a non-suppressor of eye phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of midline glial cell phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of ommatidium phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of wing phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of posterior crossvein phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of crossvein phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of wing vein L4 phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of wing vein L5 phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of photoreceptor cell R7 phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of wing vein | ectopic phenotype of Ras85D^R68Q

(Gafuik and Steller, 2011)

aos^Δ7 is a non-suppressor of eye photoreceptor cell | somatic clone phenotype of mop^T612

(Miura et al., 2008)

aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R7 | somatic clone | third instar larval stage phenotype of rasp^T392

(Miura et al., 2006)

aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R6 | somatic clone | third instar larval stage phenotype of rasp^T392

(Miura et al., 2006)

aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R5 | somatic clone | third instar larval stage phenotype of rasp^T392

(Miura et al., 2006)

aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R4 | somatic clone | third instar larval stage phenotype of rasp^T392

(Miura et al., 2006)

aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R3 | somatic clone | third instar larval stage phenotype of rasp^T392

(Miura et al., 2006)

aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R2 | somatic clone | third instar larval stage phenotype of rasp^T392

(Miura et al., 2006)

aos^Δ7/aos^Δ7 is a non-suppressor of photoreceptor cell R1 | somatic clone | third instar larval stage phenotype of rasp^T392

(Miura et al., 2006)

aos^Δ7 is a non-suppressor of chemosensory ventral triple row & microchaeta | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7 is a non-suppressor of dorsal triple row & microchaeta | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7 is a non-suppressor of dorsocentral bristle | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

aos^Δ7 is a non-suppressor of scutellar bristle | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

Other

Statement

Reference

aos[+]/aos^Δ7, goe^5-11/goe³³¹ has female germline stem cell phenotype

(Matsuoka et al., 2014)

Ack^UAS.cSb, Scer\GAL4^GMR.PU, aos[+]/aos^Δ7 has pigment cell | increased number phenotype

(Schoenherr et al., 2012)

Dys^RNAi.NH2.UAS, aos[+]/aos^Δ7 has wing vein | ectopic phenotype

(Kucherenko et al., 2008)

aos^Δ7, sty^Δ5 has ommatidial precursor cluster | somatic clone phenotype

(Brown et al., 2006)

Gug¹⁴⁹⁶⁷, aos^Δ7, rho^7M43, ru¹ has eye photoreceptor cell | somatic clone phenotype

(Charroux et al., 2006)

Delta^X, aos^Δ7 has dorsal oblique muscle cell | ectopic phenotype

(Carmena et al., 2002)

Delta^X, aos^Δ7 has dorsal oblique muscle cell | precursor | ectopic phenotype

(Carmena et al., 2002)

aos^Δ7, sty^S73 has eye phenotype

(Casci et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

aos^Δ7 dominantly enhances the increased differentiating germ cell phenotype in goe^5-11/goe³³¹ mutant larval ovaries.

While neither goe^5-11/goe³³¹ nor aos^Δ7/+ ovaries exhibit a remarkable reduction in the number of germline stem cells (GSCs) at white pupal stage, establishment is severely impaired in goe^5-11/goe³³¹; aos^Δ7/+ ovaries. This reduction in GSC number is likely the result of an insufficient primordial germ cell pool, because both ovariole formation and niche development occur normally in goe^5-11/goe³³¹; aos^Δ7/+ ovaries.

(Matsuoka et al., 2014)

An aos^Δ7 mutant background does not alter the ommatidial rotation phenotype seen in flies expressing miple1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.2sev.

An aos^Δ7 mutant background enhances the eye roughness seen in flies expressing miple1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

(Muñoz-Soriano et al., 2013)

Heterozygosity for aos^Δ7 does not suppress the small eye phenotype caused by W^Ala5.GMR.

Expression of Ack^{K156A.Scer\UAS} under the control of Scer\GAL4^GMR.PU in conjunction with aos^Δ7/+ does not suppress the small eye phenotype caused by W^Ala5.GMR.

Expression of Ack^Scer\UAS.cSb under the control of Scer\GAL4^GMR.PU suppresses the small eye phenotype caused by W^Ala5.GMR. Further suppression is seen if the flies are also heterozygous for aos^Δ7/+.

Animals expressing Ack^Scer\UAS.cSb under the control of Scer\GAL4^GMR.PU in a aos^Δ7/+ background show a 25% increase in pigment cell number when assessed at 42% pupa development.

(Schoenherr et al., 2012)

One copy of aos^Δ7 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of aos^Δ7 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of aos^Δ7 dramatically enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The eyes also appear rougher than in sl² mutants alone.

(Murillo-Maldonado et al., 2011)

One copy of aos^Δ7 enhances the extra wing vein phenotype seen in sty^S73 heterozygotes at 29[o]C.

One copy of aos^Δ7 enhances the extra vein phenotype seen in rho-5^KO1 sty^S73 double heterozygotes at 29[o]C.

(Zettl et al., 2011)

The rough-eye phenotype observed in Fas2^EB112/Fas2^e76 flies is enhanced by the presence of argos^Δ7/+.

(Mao and Freeman, 2009)

The presence of a argos^Δ7 background significantly enhances ectopic wing vein formation found in csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) mutants.

(Oishi et al., 2009)

One copy of aos^Δ7 strongly suppresses the detached posterior crossvein phenotype seen when Dys^{dsRNA.NH2.Scer\UAS} is expressed under the control of Scer\GAL4^Act.PU but produces extra wing vein material.

One copy of aos^Δ7 enhances the posterior crossvein phenotype seen when Dg^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^tub.PU.

(Kucherenko et al., 2008)

The loss of photoreceptor cells seen in homozygous mop^T612 clones in the eye disc is not rescued if the clones are also homozygous for argos^Δ7.

(Miura et al., 2008)

argos^Δ7 does not protect Df(1)su(s)R194/+ clones in the eye; Df(1)su(s)R194/+ ; argos^Δ7 clones are not recovered in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36^+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). Also, argos^Δ7 does not prevent apoptosis of Df(1)su(s)R194/+ cells in the wing.

(Tyler et al., 2007)

argos^Δ7 sty^Δ5 Minute clones in the eye disc form large, disorganised clusters in the morphogenetic furrow compared to the clusters formed in wild-type eye discs.

(Brown et al., 2006)

The extra photoreceptor cell phenotype of argos^Δ7 clones is enhanced in argos^Δ7 Gug¹⁴⁹⁶⁷ clones, with a greater percentage of ommatidia showing supernumerary photoreceptor cells. These extra photoreceptor cells are never R8 cells. In contrast, ru¹ rho^7M43 Gug¹⁴⁹⁶⁷ argos^Δ7 mutant clones lack photoreceptor cells.

(Charroux et al., 2006)

The ed^4.12 R8 cell twinning phenotype is strongly enhanced by argos^Δ7/+.

(Rawlins et al., 2003)

argos^Δ7/+ mildly enhances the ed^k01102 phenotype; the number of ommatidia with multiple R8 cells is increased from 18% to 34% in the double mutant flies.

(Spencer and Cagan, 2003)

The addition of argos^Δ7/+ enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. Heterozygotes suppress the ommatidial polarity defects seen in Ras64B^V14.Act5C.

(Strutt and Strutt, 2003)

The eye blistering phenotype seen in argos^Δ7/argos⁰⁵⁸⁴⁵ escaper adults is enhanced by rno³/+, so that it covers much of the eye. The rough eye phenotype of Ras85D^V12.sev flies is enhanced by argos^Δ7/+.

(Voas and Rebay, 2003)

The notching seen in wings of N^55e11/+ flies is not enhanced in argos^Δ7/+ mutants. While Cct1¹⁶⁹¹⁹/+, argos^Δ7/+ double heterozygotes have no eye defects, N^55e11/+; Cct1¹⁶⁹¹⁹/+, argos^Δ7/+ triple heterozygotes show an enhancement in the defective eye phenotype (loss of photoreceptor cells, defects in ommatidial polarity and chirality and a partial loss of the ventral eye) seen in Cct1¹⁶⁹¹⁹ mutants.

(Weber et al., 2003)

The EPC and DA1 phenotype seen in argos^Δ7 and Dl^X exhibit a synergistic effect on each other when combined. An increase in the number of DO2 muscles is also seen.

(Carmena et al., 2002)

salm^unspecified argos^Δ7 double mutant embryos have a dramatic chordotonal organ overproduction phenotype that is more severe than that seen in either single mutant. 9 or more lateral chordotonal organs per hemisegment are frequently seen, that are often (as in salm^unspecified single mutants) scattered in lateral and dorsal positions. The double mutant embryos lack oenocytes.

(Elstob et al., 2001)

A argos^Δ7 background enhances the eye and wing vein phenotype of Scer\GAL4^GMR.PF Cbl^Dv.Scer\UAS mutants.

(Robertson et al., 2000)

sty^S73/argos^Δ7 double heterozygotes have a mild rough eye phenotype.

(Casci et al., 1999)

Transheterozygotes with bul^bp are semi-lethal, surviving adults display an eye phenotype.

(Wemmer and Klämbt, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

aos^W11

(Zartman et al., 2009)

aos^p1

(Zartman et al., 2009)

aos²⁵⁷

(Zartman et al., 2009)

Rescued by

aos^Δ7/Df(3L)Exel6129 is rescued by aos^UAS.cAa/Scer\GAL4^hs.2sev

(Alvarado et al., 2006)

Partially rescued by

aos^Δ7/Df(3L)Exel6129 is partially rescued by aos^S371F.UAS/Scer\GAL4^hs.2sev

(Alvarado et al., 2006)

aos^Δ7/Df(3L)Exel6129 is partially rescued by aos^V146D.UAS/Scer\GAL4^hs.2sev

(Alvarado et al., 2006)

aos^Δ7/Df(3L)Exel6129 is partially rescued by aos^P372S.UAS/Scer\GAL4^hs.2sev

(Alvarado et al., 2006)

Not rescued by

aos^Δ7/Df(3L)Exel6129 is not rescued by aos^C141Y.UAS/Scer\GAL4^hs.2sev

(Alvarado et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

1004

106162

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

aos^1Δ7

(Szuts et al., 1998)

aos^IΔ7

(Szuts et al., 1997)

aos^d7

(Chang et al., 2003, Weber et al., 2003, Daniel et al., 1999, Dumstrei et al., 1998)

aos^delta7

(Firth et al., 2000)

aos^lΔ7

(Helman et al., 2011, Maybeck and Röper, 2009)

arg^1Δ7

(Gafuik and Steller, 2011, Bergmann et al., 1998)

argos^-

(Lawrence et al., 2002)

argos^1Δ7

(Brown et al., 2006, Charroux et al., 2006, Sapir et al., 1998)

argos^Delta7

(Curtis et al., 2011)

argos^IΔ7

(Sudarsan et al., 2002, Baonza et al., 2001, Casci et al., 1999, Wasserman and Freeman, 1998, Gabay et al., 1997)

argos^delta7

(Matsuoka et al., 2014, Chen et al., 2005, Melen et al., 2005)

argos^gilD7

(Rawlins et al., 2003)

argos^lΔ7

(Mao and Freeman, 2009, Schlesinger et al., 2004, Freeman and Bienz, 2001, Golembo et al., 1996, Schweitzer et al., 1995)

argos^Δ7

(Schoenherr et al., 2012, Curtis et al., 2011, Djiane and Mlodzik, 2010, Zartman et al., 2009, Brodu et al., 2004, Robertson et al., 2000)

gil^Δ7

Name Synonyms

argosIΔ7

(Zettl et al., 2011)

Secondary FlyBase IDs

References (74)

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