FlyBase Allele Report: Dmel\vn[1]

General Information

Symbol

Dmel\vn¹

Species

D. melanogaster

Name

FlyBase ID

FBal0018018

Feature type

allele

Associated gene

Dmel\vn

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Milan et al., 1997)

Mutagen

X ray

(Simcox et al., 1996, Puro, 1982)

Progenitor genotype

Cytology

Description

Insertion of approximately 5kb into the region 5' of the vn transcription unit.

(Schnepp et al., 1996)

5.5kb insertion.

(Simcox et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(de Celis, 1997, Simcox et al., 1996)

visible

(Nagel et al., 2016, Wessells et al., 1999)

visible (with vn^C221)

(Rendina et al., 2010)

visible (with vn^L6)

(Austin et al., 2014)

visible (with vn^L6), with Scer\GAL4^vn-GAL4, vn^UAS.cSa

(Austin et al., 2014)

visible | recessive

(Baonza and Garcia-Bellido, 1999, Roch et al., 1998)

Phenotype Manifest In

anterior crossvein

(Wessells et al., 1999, Price et al., 1997, Simcox et al., 1996, Puro, 1982)

crossvein

(Garcia-Bellido et al., 1994)

posterior crossvein

(Puro, 1982)

wing

(Wessells et al., 1999)

wing vein

(Wessells et al., 1999, de Celis, 1997, Sturtevant and Bier, 1995, Garcia-Bellido et al., 1994)

wing vein | adult stage

(Nagel et al., 2016)

wing vein | ectopic (with vn^L6), with Scer\GAL4^vn-GAL4, vn^UAS.cSa

(Austin et al., 2014)

wing vein L3

(Guichard et al., 1999, Puro, 1982)

wing vein L3 (with vn^L6)

(Austin et al., 2014)

wing vein L4

(Baonza and Garcia-Bellido, 1999, Guichard et al., 1999, Wessells et al., 1999, Price et al., 1997, Simcox et al., 1996, Puro, 1982)

wing vein L4 (with vn^C221)

(Rendina et al., 2010)

wing vein L4 (with vn^L6)

(Austin et al., 2014)

Detailed Description

Statement

Reference

The vn¹ mutants have gaps in the longitudinal veins of the adult wing.

(Nagel et al., 2016)

vn^L6/vn¹ mutant wings show loss of part of longitudinal vein 4 and the anterior crossvein. Very few flies show loss of longitudinal vein 3.

(Austin et al., 2014)

vn¹/vn^C221 animals lack the L4 wing vein.

(Rendina et al., 2010)

vn¹/vn^ddd-3 flies show loss of wing vein L4.

(Baonza and Garcia-Bellido, 1999)

vn¹ homozygotes show a truncation of wing vein L4, with partial penetrance at the proximal part of wing vein L3.

(Guichard et al., 1999)

In the wing, the anterior crossvein and parts of wing vein L4 are deleted.

(Wessells et al., 1999)

vn^C221/vn¹ transheterozygotes are viable and display deletions of the anterior crossvein and a portion of wing vein L4 proximal to the posterior crossvein.

(Price et al., 1997)

vn¹ rho^ve-1 double homozygotes lack all longitudinal wing veins. Vein tissue differentiates in vn¹ rho^ve-1 double homozygotes when dpp^Scer\UAS.cSa is expressed in these flies using Scer\GAL4^C-580.

(de Celis, 1997)

Homozygotes exhibit interruption of wing vein 4 (usually in the central portion) and the anterior crossvein is absent.

(Simcox et al., 1996)

Loss of vein mutation. Suppression of rho^hs.PSt ectopic vein phenotype and enhancement of the rho^ve-1 loss of vein phenotype.

(Sturtevant and Bier, 1995)

Missing short stretches of both longitudinal and crossveins. Heteroallelic combinations cause smaller wings, in addition to gaps in wing veins.

(Garcia-Bellido et al., 1994)

LIV vein gaps and anterior crossveins appear in vn¹ homozygotes.

(Diaz-Benjumea and Garcia-Bellido, 1990)

A large section of wing vein L4 and the anterior crossvein is missing. The posterior crossvein is often incomplete, and there is sometimes a gap at the base of vein L3.

(Puro, 1982)

Large section of vein L4 and anterior crossvein missing. Posterior crossvein often incomplete; gap sometimes present in L3. male-sterile female-fertile.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

vn^L6/vn¹ has visible phenotype, enhanceable by Krn⁹/Krn²⁷

(Austin et al., 2014)

vn^ddd-3/vn¹ has visible phenotype, enhanceable by emc^D

(Baonza and Garcia-Bellido, 1999)

NOT Enhanced by

Statement

Reference

vn^L6/vn¹ has visible phenotype, non-enhanceable by spi¹/spi[+]

(Austin et al., 2014)

Suppressed by

Statement

Reference

vn¹ has visible phenotype, suppressible by CycG^HR7

(Nagel et al., 2016)

vn^C221/vn¹ has visible phenotype, suppressible by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

vn^ddd-3/vn¹ has visible phenotype, suppressible by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

rho⁹/rho^ve-1, vn^M2/vn¹ has visible phenotype, suppressible by bs⁰³²⁶⁷/bs²

(Roch et al., 1998)

Enhancer of

Statement

Reference

vn¹ is an enhancer of visible phenotype of rho^ve-1

(Nagel et al., 2016)

Suppressor of

Statement

Reference

vn[+]/vn¹ is a suppressor of increased occurrence of cell division | adult stage phenotype of rk¹

(Scopelliti et al., 2014)

vn¹⁰⁵⁶⁷/vn¹ is a suppressor of increased occurrence of cell division | adult stage phenotype of rk¹

(Scopelliti et al., 2014)

vn[+]/vn¹ is a suppressor of visible phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

vn[+], rho^ve-1, vn¹, rho[+] is a suppressor of visible phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

vn[+]/vn¹ is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

vn[+], vn¹, rho^7M43, rho[+] is a suppressor | partially of visible phenotype of Scer\GAL4^en-e16E, tum^ΔE1E.UAS

(Sotillos and Campuzano, 2000)

Other

Statement

Reference

pk³⁰, rho^ve-1, vn¹ has visible phenotype

(Hogan et al., 2011)

pk³⁰, rho^ve-1, vn¹ has abnormal planar polarity phenotype

(Hogan et al., 2011)

rho^ve-1, vn¹ has visible | recessive phenotype

(Martin-Blanco et al., 1999, Milan et al., 1997)

rho⁹/rho^ve-1, vn^M2/vn¹ has visible phenotype

(Roch et al., 1998)

rho^ve-1, vn¹ has visible phenotype

(Wolfgang et al., 1996)

Phenotype Manifest In

Enhanced by

Statement

Reference

vn^L6/vn¹ has wing vein L3 phenotype, enhanceable by Krn⁹/Krn²⁷

(Austin et al., 2014)

vn^ddd-3/vn¹ has wing vein phenotype, enhanceable by emc^D

(Baonza and Garcia-Bellido, 1999)

NOT Enhanced by

Statement

Reference

vn^L6/vn¹ has wing vein L3 phenotype, non-enhanceable by spi¹/spi[+]

(Austin et al., 2014)

vn¹ has wing vein phenotype, non-enhanceable by spi¹

(Guichard et al., 1999)

Suppressed by

Statement

Reference

vn¹ has wing vein | adult stage phenotype, suppressible by CycG^HR7

(Nagel et al., 2016)

vn^C221/vn¹ has wing vein L4 phenotype, suppressible by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

rho^ve-1, vn¹ has wing vein phenotype, suppressible | partially by ash2^S112411/ash2^S112411

(Angulo et al., 2004)

vn^ddd-3/vn¹ has wing vein L4 phenotype, suppressible by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

vn¹ has phenotype, suppressible by bs⁰³²⁶⁷

(Roch et al., 1998)

rho⁹/rho^ve-1, vn^M2/vn¹ has wing vein phenotype, suppressible by bs⁰³²⁶⁷/bs²

(Roch et al., 1998)

rho^ve-1, vn¹ has wing vein phenotype, suppressible by dpp^UAS.cSa/Scer\GAL4^C-580

(de Celis, 1997)

NOT suppressed by

Statement

Reference

rho^ve-1, vn¹ has wing vein phenotype, non-suppressible by osa^UAS.cCa/Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

Enhancer of

Statement

Reference

vn¹ is an enhancer of wing vein L4 | adult stage phenotype of rho^ve-1

(Nagel et al., 2016)

NOT Enhancer of

Statement

Reference

rho^ve-1/vn¹ is a non-enhancer of wing vein | ectopic phenotype of bwk^Δ11, cic^D49

(Roch et al., 2002)

vn¹ is a non-enhancer of wing disc phenotype of ft^k07918

(Garoia et al., 2000)

Suppressor of

Statement

Reference

vn[+]/vn¹ is a suppressor of intestinal stem cell phenotype of rk¹

(Scopelliti et al., 2014)

vn[+]/vn¹ is a suppressor of adult midgut phenotype of rk¹

(Scopelliti et al., 2014)

vn¹⁰⁵⁶⁷/vn¹ is a suppressor of intestinal stem cell phenotype of rk¹

(Scopelliti et al., 2014)

vn¹⁰⁵⁶⁷/vn¹ is a suppressor of adult midgut phenotype of rk¹

(Scopelliti et al., 2014)

vn[+]/vn¹ is a suppressor of wing vein phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

vn[+], rho^ve-1, vn¹, rho[+] is a suppressor of wing vein phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

vn[+]/vn¹ is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

vn[+]/vn¹ is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

vn[+], vn¹, rho^7M43, rho[+] is a suppressor | partially of wing phenotype of Scer\GAL4^en-e16E, tum^ΔE1E.UAS

(Sotillos and Campuzano, 2000)

NOT Suppressor of

Statement

Reference

vn¹ is a non-suppressor of wing disc phenotype of ft^k07918

(Garoia et al., 2000)

Other

Statement

Reference

pk³⁰, rho^ve-1, vn¹ has wing hair phenotype

(Hogan et al., 2011)

pk³⁰, rho^ve-1, vn¹ has wing vein phenotype

(Hogan et al., 2011)

rho^ve-1, vn¹ has wing vein phenotype

(Terriente-Félix and de Celis, 2009, Ralston and Blair, 2005, Martin-Blanco et al., 1999, de Celis, 1997, Milan et al., 1997)

rho⁹/rho^ve-1, vn¹ has wing vein phenotype

(Roch et al., 1998)

rho⁹/rho^ve-1, vn^M2/vn¹ has wing vein phenotype

(Roch et al., 1998)

rho^ve-1, vn¹ has crossvein phenotype

(Milan et al., 1997)

rho^ve-1, vn¹ has wing phenotype

(Wolfgang et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

rho^ve-1,vn¹ double mutants almost completely lack veins in the adult wing. This phenotype was not changed by in rho^ve-1,vn¹,CycG^HR7 triple mutants.

The loss of vein material in vn¹ is mildly suppressed in vn¹,CycG^HR7 double mutants.

(Nagel et al., 2016)

Krn²⁷/Krn⁹ enhances the wing vein phenotypes seen in vn^L6/vn¹ mutants. A greater proportion of flies show longitudinal vein 3 loss than in vn^L6/vn¹ alone. The phenotype is further enhanced by one copy of spi¹.

One copy of spi¹ does not enhance the vein phenotypes seen in vn^L6/vn¹ mutant wings.

(Austin et al., 2014)

vn¹/+ or vn¹⁰⁵⁶⁷/vn¹ suppresses the intestinal stem cell hyperproliferation seen in rk¹/rk¹ mutant midguts.

(Scopelliti et al., 2014)

rho^ve-1, vn¹ double mutant wings retain wild-type hair polarity and ridge orientation.

Wings of homozygous pk³⁰, rho^ve-1 and vn¹ triple mutant flies lack veins L2-5. Wing anterior hairs of these mutants consistently have a posterior component to their polarity and posterior hairs have an anterior component to their polarity.

(Hogan et al., 2011)

The loss of wing vein L4 which is seen in vn¹/vn^C221 animals is rescued by Bap170^hfl1/+ in 90% of cases.

(Rendina et al., 2010)

The wings of rho^ve-1 vn¹ double mutants examined at 19, 21 or 24 hours after pupariation (AP) lack most longitudinal veins, with only the most proximal vein tissue intact 19 and 21 hours AP.

(Ralston and Blair, 2005)

rho^ve-1 vn¹ double homozygotes lack wing veins. This phenotype is partially suppressed by ash2^S112411 /ash2^S112411. The degree of suppression varies from development of L2 only to almost complete rescue, albeit with some abnormalities such as extra crossvein material or proximal fusions between L2 and L3 or L4 and L5. In 25% of cases, hollow, tube like wings are formed, probably due to detachment of dorsal and ventral layers.

(Angulo et al., 2004)

The addition of bwk^Δ11 and vn¹ fails to enhance the extra wing vein phenotype seen in cic^D49/bwk^Δ11 animals.

(Roch et al., 2002)

The vn¹/vn^ddd-3 loss of wing vein L4 phenotype is suppressed by emc¹/emc¹¹. emc^D enhances the loss of wing veins seen in vn¹/vn^ddd-3 flies. emc¹ clones in rho^ve-1 vn¹ wings differentiate as veins in positions possibly corresponding to those of wild-type veins. Vein differentiation in these clones frequently fails in distal regions of veins.

(Baonza and Garcia-Bellido, 1999)

In vn¹ homozygotes, there is no exacerbation of the loss of vein phenotype within homozygous spi¹ clones in the wing.

(Guichard et al., 1999)

vn¹ rho^ve-1 flies completely lack wing veins.

(Martin-Blanco et al., 1999)

rho⁹, vn^M2/rho^ve-1, vn¹ double mutants lack wing veins. bs⁰³²⁶⁷/bs²; rho⁹, vn^M2/rho^ve-1, vn¹ triple mutants show an almost wild type wing vein pattern.

(Roch et al., 1998)

rho^ve-1 vn¹ double mutant flies lack all the longitudinal veins and crossveins of the wing blade. Dorsal and ventral implants of rho^ve-1 vn¹ imaginal disc tissue into wild-type imaginal discs fail to differentiate veins.

(Milan et al., 1997)

vn¹ rho^ve-1 flies lack wing veins.

(Wolfgang et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

vn^L6/vn¹ is partially rescued by vn^UAS.cSa/Scer\GAL4^vn-GAL4

(Austin et al., 2014)

Comments

Images (0)

Mutant

Wild-type

Stocks (6)

Bloomington

603542

rho^ve-1 vn¹

7287

l(3)9358⁹³⁵⁸ vn¹ st¹/DcxF

7288

l(3)B197^B197 vn¹ st¹/DcxF

7292

Hmbs^7E130 vn¹ st¹/TM6B, Tb¹

7291

ND-ACP¹³⁰³ vn¹ st¹/TM6B, Tb¹

7284

l(3)8E276^8E276 vn¹ st¹/TM6B, Tb¹

Notes on Origin

Discoverer

Puro, 1960.

(Puro, 1982)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Puro, 1982)

vn¹

(Tsuboi et al., 2023, Zhu et al., 2017, Nagel et al., 2016, Austin et al., 2014, Scopelliti et al., 2014, Valentine et al., 2014, Ajuria et al., 2011, Casso et al., 2011, Hogan et al., 2011, Rendina et al., 2010, Terriente-Félix and de Celis, 2009, Angulo et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (37)

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