FlyBase Allele Report: Dmel\Krn[27]

General Information

Symbol

Dmel\Krn²⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0277265

Feature type

allele

Associated gene

Dmel\Krn

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

No wing phenotypes are seen in Krn²⁷/Krn⁹ mutant flies.

(Austin et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Krn⁹/Krn²⁷ is an enhancer of visible phenotype of vn^L6/vn¹

(Austin et al., 2014)

Suppressor of

Statement

Reference

spi¹/Krn²⁷ is a suppressor | partially of visible phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

vn^L6/Krn²⁷ is a suppressor | partially of visible phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

spi¹, vn^L6, Krn²⁷ is a suppressor of visible phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

NOT Suppressor of

Statement

Reference

Krn²⁷ is a non-suppressor of visible phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Krn²⁷, spi¹ has ventral denticle belt phenotype, enhanceable by vn^L6

(Austin et al., 2014)

NOT Enhanced by

Statement

Reference

Krn²⁷, spi¹, vn^L6 has ventral denticle belt phenotype, non-enhanceable by grk^HF

(Austin et al., 2014)

Enhancer of

Statement

Reference

Krn²⁷ is an enhancer of ventral denticle belt phenotype of spi¹, vn^L6

(Austin et al., 2014)

Krn²⁷ is an enhancer of ventral denticle belt phenotype of spi¹

(Austin et al., 2014)

Krn⁹/Krn²⁷ is an enhancer of wing vein L3 phenotype of vn^L6/vn¹

(Austin et al., 2014)

Suppressor of

Statement

Reference

spi¹/Krn²⁷ is a suppressor | partially of wing vein | ectopic phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

vn^L6/Krn²⁷ is a suppressor | partially of wing vein | ectopic phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

spi¹, vn^L6, Krn²⁷ is a suppressor of wing vein | ectopic phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

NOT Suppressor of

Statement

Reference

Krn²⁷ is a non-suppressor of wing vein | ectopic phenotype of AdamTS-B^KK108644, Scer\GAL4^Act5C.PU

(Butchar et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

vn^L6 enhances the ventral patterning defects seen in spi¹ mutant embryos. The double mutants have a reduced number of denticle belts compared to controls, fusion of the denticle belts and an anterior hole. The phenotype is further exacerbated by Krn²⁷, with embryos having no denticle belts and a large anterior hole. A zygotic grk^HF mutation has no additional effect.

Krn²⁷ enhances the ventral patterning defects seen in spi¹ mutant embryos. The double mutants have a reduced number of denticle belts compared to controls, fusion of the denticle belts and an anterior hole. The phenotype is further exacerbated by vn^L6, with embryos having no denticle belts and a large anterior hole. A zygotic grk^HF mutation has no additional effect.

Krn²⁷/Krn⁹ enhances the wing vein phenotypes seen in vn^L6/vn¹ mutants. A greater proportion of flies show longitudinal vein 3 loss than in vn^L6/vn¹ alone. The phenotype is further enhanced by one copy of spi¹.

(Austin et al., 2014)

The extra wing vein phenotype caused by expression of CG4096^KK108644 under the control of Scer\GAL4^Act5C.PU is not suppressed if the flies also carry Krn²⁷.

The extra wing vein phenotype caused by expression of CG4096^KK108644 under the control of Scer\GAL4^Act5C.PU is significantly suppressed if the also simultaneously carry both spi¹ and Krn²⁷, or both vn^L6 and Krn²⁷. The suppression is more pronounced if the flies simultaneously carry spi¹, Krn²⁷ and vn^L6.

(Butchar et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Krn²⁷

(Austin et al., 2014)

krn²⁷

(Butchar et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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