FlyBase Allele Report: Dmel\arm[GD1372]

General Information

Symbol

Dmel\arm^GD1372

Species

D. melanogaster

Name

FlyBase ID

FBal0209078

Feature type

allele

Associated gene

Dmel\arm

Associated Insertion(s)

Carried in Construct

P{GD1372}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1372}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1372

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Zhang et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | oogenesis, with Scer\GAL4^bab1-Gal4

(Lin et al., 2020)

abnormal size | adult stage, with Scer\GAL4^nub.PU

(Won et al., 2019)

abnormal size | adult stage, with Scer\GAL4^wg-Gal4

(Won et al., 2019)

lethal, with Scer\GAL4^tsh-md621

(Petzoldt et al., 2012)

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible | adult stage, with Scer\GAL4^nub.PU

(Won et al., 2019)

visible | adult stage, with Scer\GAL4^wg-Gal4

(Won et al., 2019)

Phenotype Manifest In

adult heart, with Scer\GAL4^tin.CΔ4

(Casad et al., 2012)

egg chamber, with Scer\GAL4^NP1624

(Sarpal et al., 2012)

female germline stem cell, with Scer\GAL4^bab1-Gal4

(Lin et al., 2020)

germarium, with Scer\GAL4^bab1-Gal4

(Lin et al., 2020)

male genitalia, with Scer\GAL4^Abd-B-LDN

(Petzoldt et al., 2012)

male genitalia, with Scer\GAL4^NP1548

(Petzoldt et al., 2012)

mesothoracic tergum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

ovary, with Scer\GAL4^NP1624

(Sarpal et al., 2012)

wing, with Scer\GAL4^nub.PU

(Won et al., 2019)

wing, with Scer\GAL4^wg-Gal4

(Won et al., 2019)

Detailed Description

Statement

Reference

The expression of arm^GD1372 under the control of either Scer\GAL4^nub.PU or Scer\GAL4^wg-Gal4 leads to extremely small and deformed wings.

(Won et al., 2019)

Expression of arm^GD1372 in the heart under the control of Scer\GAL4^tin.CΔ4 results in flies with markedly smaller hearts and significantly reduced end diastolic dimension (EDD). Heart wall thickness is also significantly increased. Accumulated material can be seen within the lumen of the heart that occupies a large portion of the cross-sectional area of the vessel chamber.

(Casad et al., 2012)

Males expressing arm^GD1372 under the control of either Scer\GAL4^{Myo31DF-NP1548} or Scer\GAL4^Abd-B-LDN sometimes show partial rotation of the genitalia.

(Petzoldt et al., 2012)

Expression of arm^GD1372 in follicle cells under the control of Scer\GAL4^tj-NP1624 produces oogenesis defects. Ovarioles frequently form a single giant fused egg chambers that contains multiple germline cysts.

(Sarpal et al., 2012)

Adults expressing arm^GD1372 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in early larval lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 90-100% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development