FlyBase Allele Report: Dmel\alka[JF02149]

General Information

Symbol

Dmel\alka^JF02149

Species

D. melanogaster

Name

FlyBase ID

FBal0220637

Feature type

allele

Associated gene

Dmel\alka

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02149}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02149}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02149

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm | adult stage, with Scer\GAL4^Clk.1.5

(Frenkel et al., 2017)

abnormal circadian rhythm | adult stage, with Scer\GAL4^Clk.-856

(Frenkel et al., 2017)

abnormal circadian rhythm | adult stage, with Scer\GAL4^Mai179, Scer\GAL80^Pdf.PS

(Frenkel et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Under constant darkness conditions: the expression of CG12344^JF02149 under the control of Scer\GAL4^Clk.2341 leads to a small but significant decrease in circadian period, but to insignificant changes in the proportion of rhythmic individuals, as compared to controls; expression under the control of Scer\GAL4^Clk.1.5 leads to a significant decrease in the proportion of rhythmic individuals, but to insignificant changes in circadian period, as compared to controls; expression under the combined control of Scer\GAL4^cry.PE and Scer\GAL80^Pdf.PS leads to insignificant changes in circadian period or in the proportion of rhythmic individuals, as compared to controls; expression under the combined control of Scer\GAL4^Mai179 and Scer\GAL80^Pdf.PS leads to significant decreases in circadian period and in the proportion of rhythmic individuals, as compared to controls.

(Frenkel et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Clk.1.5, alka^JF02149 has abnormal circadian rhythm | adult stage phenotype, enhanceable by Scer\GAL4^Clk.1.5/SecCl^JF02437/Grd^GD2702

(Frenkel et al., 2017)

Scer\GAL4^Clk.-856, alka^JF02149 has abnormal circadian rhythm | adult stage phenotype, enhanceable by SecCl^JF02437/Scer\GAL4^Clk.-856/Grd^GD2702

(Frenkel et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Mai179, Scer\GAL80^Pdf.PS, alka^JF02149 has abnormal circadian rhythm | adult stage phenotype, non-enhanceable by SecCl^JF02437/Scer\GAL4^Mai179/Grd^GD2702, Scer\GAL80^Pdf.PS

(Frenkel et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^Clk.1.5, Grd^GD2702, alka^JF02149 is an enhancer of abnormal circadian rhythm | adult stage phenotype of Scer\GAL4^Clk.1.5, SecCl^JF02437

(Frenkel et al., 2017)

NOT Enhancer of

Statement

Reference

SecCl^JF02437, Scer\GAL4^Mai179, alka^JF02149, Scer\GAL80^Pdf.PS is a non-enhancer of abnormal circadian rhythm | adult stage phenotype of Grd^GD2702, Scer\GAL4^Mai179, Scer\GAL80^Pdf.PS

(Frenkel et al., 2017)

Scer\GAL4^Mai179, Grd^GD2702, alka^JF02149, Scer\GAL80^Pdf.PS is a non-enhancer of abnormal circadian rhythm | adult stage phenotype of Scer\GAL4^Mai179, Scer\GAL80^Pdf.PS, SecCl^JF02437

(Frenkel et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^Clk.1.5, SecCl^JF02437, alka^JF02149 is a suppressor of abnormal circadian rhythm | adult stage phenotype of Grd^GD2702, Scer\GAL4^Clk.1.5

(Frenkel et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Under constant darkness conditions: the triple co-expression of CG12344^JF02149, Grd^GD2702 and CG7589^JF02437 under the control of Scer\GAL4^Clk.2341 enhances the small decrease in circadian period observed upon the single expression of CG12344^JF02149; triple co-expression under the control of Scer\GAL4^Clk.1.5 suppresses the small increase in circadian period observed upon the single expression of Grd^GD2702, even leading to a significant decrease in period as compared to controls, and enhances the decreased proportion of rhythmic individuals conditions observed upon the single expression of either CG12344^JF02149 or CG7589^JF02437; triple co-expression under the combined control of Scer\GAL4^Mai179 and Scer\GAL80^Pdf.PS leads to a similar decrease in circadian period as upon the single expression of Grd^GD2702 and to similar decreases in the proportion of rhythmic individuals conditions as upon the single expression of CG12344^JF02149 or CG7589^JF02437.

(Frenkel et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26250

y¹ v¹; P{TRiP.JF02149}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG12344^JF02149

alka^JF02149

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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